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排序方式: 共有266条查询结果,搜索用时 31 毫秒
1.
van Geel N Speeckaert R Mollet I De Schepper S De Wolf J Tjin EP Luiten RM Lambert J Brochez L 《Pigment cell & melanoma research》2012,25(1):57-65
In this study, we developed an in vivo vitiligo induction model to explore the underlying mechanisms leading to Koebner's phenomenon and to evaluate the efficacy of therapeutic strategies. The model consisted of 12 pigmented test regions on the back of generalized vitiligo patients that were exposed to three Koebner induction methods: cryotherapy, 755 nm laser therapy, and epidermal abrasion. In addition, four cream treatments (pimecrolimus, tacrolimus, steroid and placebo) were randomly applied. Koebnerization was efficiently induced by all three induction methods. In general, cryotherapy was the best method of Koebner induction, followed by 755 nm laser therapy and epidermal abrasion. Reproducible results were obtained, which showed enhanced depigmented surface areas and higher amounts of T lymphocytes in placebo-treated test zones compared to active treated areas. Tacrolimus and local steroids were better inhibitors of Koebner's process (P < 0.05) compared to pimecrolimus. Our in vivo vitiligo induction model is very informative to investigate vitiligo induction and to determine the efficacy of topical treatments in vitiligo. This proof of concept confirms the efficient comparison of head-to-head therapeutic strategies intra-individually in a standardized, specific and better timed way. 相似文献
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Corine Vialas Geneviève Pratviel Jean Bernadou Bernard Meunier 《Nucleosides, nucleotides & nucleic acids》2013,32(4-5):1061-1063
Abstract Mn TMPyP in the presence of sulfite/O2 catalyses the oxidation of dG into dIz as selectively but slower and less efficiently than in the presence of KHSO5. 相似文献
4.
Tom D. Bunney Diego Esposito Corine Mas-Droux Ekatarina Lamber Rhona W. Baxendale Marta Martins Ambrose Cole Dmitri Svergun Paul C. Driscoll Matilda Katan 《Structure (London, England : 1993)》2012,20(12):2062-2075
Highlights? Domains from PLCγ regulatory region show structural and functional integration ? Only cSH2 domain interacts with the PLC-core forming a high affinity surface ? Activation involves removal of autoinhibition and dissociation from the receptor ? Disease-linked mutations map to the autoinhibitory interface 相似文献
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Ezzedine K Lim HW Suzuki T Katayama I Hamzavi I Lan CC Goh BK Anbar T Silva de Castro C Lee AY Parsad D van Geel N Le Poole IC Oiso N Benzekri L Spritz R Gauthier Y Hann SK Picardo M Taieb A;Vitiligo Global Issue Consensus Conference Panelists 《Pigment cell & melanoma research》2012,25(3):E1-13
During the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: classification and nomenclature; definition of stable disease; definition of Koebner's phenomenon (KP); and 'autoimmune vitiligo'. These topics were discussed in seven working groups representing different geographical regions. A consensus emerged that segmental vitiligo be classified separately from all other forms of vitiligo and that the term 'vitiligo' be used as an umbrella term for all non-segmental forms of vitiligo, including 'mixed vitiligo' in which segmental and non-segmental vitiligo are combined and which is considered a subgroup of vitiligo. Further, the conference recommends that disease stability be best assessed based on the stability of individual lesions rather than the overall stability of the disease as the latter is difficult to define precisely and reliably. The conference also endorsed the classification of KP for vitiligo as proposed by the VETF (history based, clinical observation based, or experimentally induced). Lastly, the conference agreed that 'autoimmune vitiligo' should not be used as a separate classification as published evidence indicates that the pathophysiology of all forms of vitiligo likely involves autoimmune or inflammatory mechanisms. 相似文献
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Jonathan E. Ulmer Eric Morssing Vilén Ramesh Babu Namburi Alhosna Benjdia Julie Beneteau Annie Malleron David Bonnaffé Pierre-Alexandre Driguez Karine Descroix Gilbert Lassalle Christine Le Narvor Corine Sandstr?m Dorothe Spillmann Olivier Berteau 《The Journal of biological chemistry》2014,289(35):24289-24303
Despite the importance of the microbiota in human physiology, the molecular bases that govern the interactions between these commensal bacteria and their host remain poorly understood. We recently reported that sulfatases play a key role in the adaptation of a major human commensal bacterium, Bacteroides thetaiotaomicron, to its host (Benjdia, A., Martens, E. C., Gordon, J. I., and Berteau, O. (2011) J. Biol. Chem. 286, 25973–25982). We hypothesized that sulfatases are instrumental for this bacterium, and related Bacteroides species, to metabolize highly sulfated glycans (i.e. mucins and glycosaminoglycans (GAGs)) and to colonize the intestinal mucosal layer. Based on our previous study, we investigated 10 sulfatase genes induced in the presence of host glycans. Biochemical characterization of these potential sulfatases allowed the identification of GAG-specific sulfatases selective for the type of saccharide residue and the attachment position of the sulfate group. Although some GAG-specific bacterial sulfatase activities have been described in the literature, we report here for the first time the identity and the biochemical characterization of four GAG-specific sulfatases. Furthermore, contrary to the current paradigm, we discovered that B. thetaiotaomicron possesses an authentic GAG endosulfatase that is active at the polymer level. This type of sulfatase is the first one to be identified in a bacterium. Our study thus demonstrates that bacteria have evolved more sophisticated and diverse GAG sulfatases than anticipated and establishes how B. thetaiotaomicron, and other major human commensal bacteria, can metabolize and potentially tailor complex host glycans. 相似文献
8.
Isolation and partial characterization of an unusual human immunodeficiency retrovirus from two persons of west-central African origin. 总被引:12,自引:4,他引:8 下载免费PDF全文
R De Leys B Vanderborght M Vanden Haesevelde L Heyndrickx A van Geel C Wauters R Bernaerts E Saman P Nijs B Willems et al. 《Journal of virology》1990,64(3):1207-1216
An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgium. Although the virus shared a number of the same biological and morphological properties as human immunodeficiency retrovirus type 1 (HIV-1) and HIV-2, significant antigenic differences could be demonstrated. Several of the viral proteins also differed in molecular weight from the corresponding HIV-1 and HIV-2 proteins. Partial chemical cleavage of the most highly conserved viral proteins resulted in patterns which differed from those of HIV-1 and HIV-2. Furthermore, nucleic acid hybridization experiments were capable of discriminating between the virus types. Sequence analysis of the viral U3 region revealed a unique enhancer organization not found in other immunodeficiency viruses. The data indicated that the new isolate is more closely related to HIV-1 than to HIV-2 but clearly differs in a number of important respects. 相似文献
9.
Valerie van den Bos Otto Brinkkemper Ian D. Bull Stefan Engels Tom Hakbijl Mans Schepers Marieke van Dinter Guido van Reenen Bas van Geel 《Vegetation History and Archaeobotany》2014,23(3):277-298
Castellum Fectio was one of the largest fortifications along the Limes, the northern border of the Roman Empire. The castellum, situated 5 km southeast of Utrecht, the Netherlands, was occupied from around the start of our Era to ca. a.d. 260. It was situated along a river bend of the Rhine that was cut off from the main stream during the occupation of the Roman fort. A 6 m long sediment sequence was recovered from the infill of the residual channel and pieces of Roman wall plaster, glume bases of Triticum spelta and radiocarbon dates indicate that the sediments were deposited during the period of Roman occupation. The combined palaeoecological analyses—palynological, macrobotanical, entomological and geochemical—allow a detailed reconstruction of changing environmental conditions as a consequence of the Roman occupation. The pollen record reveals a dramatic decrease in arboreal pollen, suggesting that the Romans were involved in large-scale deforestation, transforming semi-open parkland to a landscape of meadows and agricultural fields. Non-pollen palynomorphs, botanical macrofossils and insect remains support this conclusion. The recorded mycoflora shows a shift from assemblages characterised by the tree pathogen Kretzschmaria deusta to assemblages dominated by spores of fungi associated with herbaceous plants, concurrent with the decrease in arboreal pollen. The presence of masticated bran fragments of cereals, clover remains, eggs of intestinal parasites and entomological and geochemical data in the upper part of the sequence indicates that these sediments largely consist of faeces that were dumped into the former channel. Surprisingly, seeds of salt tolerant species are encountered in the sediments of this inland site, which was situated outside the influence of the sea. Horses may have brought these seeds to Fectio in their intestinal tracts after grazing in coastal meadows. 相似文献
10.
Zhang Yunan van Geel Bas Gosling William D. Sun Guoping Qin Ling Wu Xiaohong 《Vegetation History and Archaeobotany》2020,29(1):51-60
Vegetation History and Archaeobotany - Wetlands have been attractive environments for early communities worldwide. In China, wetlands offered natural ecological settings for the start of rice... 相似文献