全文获取类型
收费全文 | 586篇 |
免费 | 56篇 |
出版年
2023年 | 4篇 |
2021年 | 6篇 |
2020年 | 5篇 |
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 7篇 |
2016年 | 16篇 |
2015年 | 21篇 |
2014年 | 33篇 |
2013年 | 44篇 |
2012年 | 61篇 |
2011年 | 39篇 |
2010年 | 24篇 |
2009年 | 34篇 |
2008年 | 33篇 |
2007年 | 32篇 |
2006年 | 42篇 |
2005年 | 36篇 |
2004年 | 30篇 |
2003年 | 17篇 |
2002年 | 28篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1999年 | 10篇 |
1998年 | 10篇 |
1997年 | 4篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 10篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1968年 | 2篇 |
1956年 | 1篇 |
1948年 | 2篇 |
排序方式: 共有642条查询结果,搜索用时 15 毫秒
1.
2.
Emilia Rabia Vronique Garambois Julie Hubert Marine Bruciamacchie Nelly Pirot Hlne Delpech Morgane Broyon Charles Theillet Pierre-Emmanuel Colombo Nadia Vie Diego Tosi Celine Gongora Lakhdar Khellaf Marta Jarlier Nina Radosevic-Robin Thierry Chards Andr Plegrin Christel Larbouret 《MABS-AUSTIN》2021,13(1)
3.
UPTAKE OF GLUCOSE ANALOGUES BY RAT BRAIN CORTEX SLICES: A KINETIC ANALYSIS BASED UPON A MODEL 总被引:1,自引:0,他引:1
Abstract— In slice preparations the exchange of dissolved substances between cells and incubation medium is delayed by diffusion through the extracellular space. The delay may seriously interfere with the study of membrane transport in terms of unidirectional fluxes across the cell membranes. A three-compartment serial model has been developed to describe exchange between slice and incubation medium. By aid of this model it is shown that the diffusion delay prevents determination of unidirectional fluxes for the two non-metabolizable glucose analogues 3-O-methylglucose and α-methyl-glucosidc. The membrane transport of the slowly transported α-methylglucoside can however be examined by aid of the model whereas the transport of 3-O-methylglucose is so rapid that it can not be examined with respect to Vmax Km and Kr . An attempt to determine these parameters will result in falsely large values which reflect extracellular diffusion and not membrane transport. 相似文献
4.
Marta Tischer Michał Gorczak Błażej Bojarski Julia Pawłowska Christel Hoffeins Hans Werner Hoffeins Marta Wrzosek 《Fungal biology》2019,123(11):804-810
Three new fossils of saprotrophic fungi are presented and described from Baltic amber, dated to Eocene epoch (Paleogene, upper to mid-Eocene). All belong to Ascomycota and are represented by hyphae as well as asexual reproduction structures allowing to assign them to present genera, respectively Periconia, Penicillium and Scopulariopsis. These material provide both the first and the oldest known fossil record of the mentioned taxa, making these data valuable for the knowledge about the evolutionary history of the Ascomycota. 相似文献
5.
Matteo Gentili Xavier Lahaye Francesca Nadalin Guilherme P.F. Nader Emilia Puig Lombardi Solène Herve Nilushi S. De Silva Derek C. Rookhuizen Elina Zueva Christel Goudot Mathieu Maurin Aurore Bochnakian Sebastian Amigorena Matthieu Piel Daniele Fachinetti Arturo Londoño-Vallejo Nicolas Manel 《Cell reports》2019,26(13):3798
6.
Shanti Souriant Luciana Balboa Maeva Dupont Karine Pingris Denise Kviatcovsky Céline Cougoule Claire Lastrucci Aicha Bah Romain Gasser Renaud Poincloux Brigitte Raynaud-Messina Talal Al Saati Sandra Inwentarz Susana Poggi Eduardo Jose Moraña Pablo González-Montaner Marcelo Corti Bernard Lagane Christel Vérollet 《Cell reports》2019,26(13):3586-3599.e7
7.
8.
Dr. Christel Hintze 《Zoomorphology》1969,64(1):1-8
The larvae of Cerura vinula L. and Notodonta anceps Goeze secrete formic acid for defence. The glandular protective system which forms the acid and changes of the cell structure were studied with the light-microscope.
Mit dankenswerter Unterstützung der Deutschen Forschungsgemeinschaft. 相似文献
Mit dankenswerter Unterstützung der Deutschen Forschungsgemeinschaft. 相似文献
9.
Tandem repeats represent one of the most abundant class of variations in human genomes, which are polymorphic by nature and become highly unstable in a length-dependent manner. The expansion of repeat length across generations is a well-established process that results in human disorders mainly affecting the central nervous system. At least 50 disorders associated with expansion loci have been described to date, with half recognized only in the last ten years, as prior methodological difficulties limited their identification. These limitations still apply to the current widely used molecular diagnostic methods (exome or gene panels) and thus result in missed diagnosis detrimental to affected individuals and their families, especially for disorders that are very rare and/or clinically not recognizable. Most of these disorders have been identified through family-driven approaches and many others likely remain to be identified. The recent development of long-read technologies provides a unique opportunity to systematically investigate the contribution of tandem repeats and repeat expansions to the genetic architecture of human disorders. In this review, we summarize the current and most recent knowledge about the genetics of repeat expansion disorders and the diversity of their pathophysiological mechanisms and outline the perspectives of developing personalized treatments in the future.Tandem repeats represent one of the most abundant class of variations in human genomes, which are polymorphic by nature and become highly unstable in a length-dependent manner. The expansion of repeat length across generations is a well-established process that results in human disorders mainly affecting the central nervous system. At least 50 disorders associated with expansion loci have been described to date, with half recognized only in the last ten years, as prior methodological difficulties limited their identification. These limitations still apply to the current widely used molecular diagnostic methods (exome or gene panels) and thus result in missed diagnosis detrimental to affected individuals and their families, especially for disorders that are very rare and/or clinically not recognizable. Most of these disorders have been identified through family-driven approaches and many others likely remain to be identified. The recent development of long-read technologies provides a unique opportunity to systematically investigate the contribution of tandem repeats and repeat expansions to the genetic architecture of human disorders. In this review, we summarize the current and most recent knowledge about the genetics of repeat expansion disorders and the diversity of their pathophysiological mechanisms and outline the perspectives of developing personalized treatments in the future. 相似文献
10.