全文获取类型
收费全文 | 327篇 |
免费 | 13篇 |
出版年
2022年 | 2篇 |
2021年 | 10篇 |
2019年 | 2篇 |
2018年 | 12篇 |
2017年 | 9篇 |
2016年 | 12篇 |
2015年 | 12篇 |
2014年 | 15篇 |
2013年 | 25篇 |
2012年 | 38篇 |
2011年 | 17篇 |
2010年 | 17篇 |
2009年 | 14篇 |
2008年 | 12篇 |
2007年 | 13篇 |
2006年 | 16篇 |
2005年 | 7篇 |
2004年 | 14篇 |
2003年 | 3篇 |
2002年 | 9篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1995年 | 2篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1974年 | 7篇 |
1973年 | 3篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1964年 | 4篇 |
1963年 | 1篇 |
1962年 | 2篇 |
1960年 | 1篇 |
1939年 | 1篇 |
1937年 | 1篇 |
1934年 | 1篇 |
排序方式: 共有340条查询结果,搜索用时 218 毫秒
1.
2.
Cimetidine is widely prescribed for the treatment of peptic ulcer disease and has recently been shown to inhibit the metabolism of warfarin, antipyrine and diazepam. To further examine this phenomenon we investigated the effect of various doses of cimetidine and other related drugs on 14C-aminopyrine, 14C-phenacetin and 14C-caffeine breath tests. Cimetidine caused a dose-related inhibition of the metabolism of aminopyrine and caffeine but had no effect on the phenacetin breath test. Metiamide, H1-antihistamines, phenothiazines and local anesthetics also inhibited the aminopyrine breath test. Cyproheptadine had no effect on either phenacetin or caffeine elimination. This study demonstrates a complex drug-drug interaction which may have widespread clinical implications. 相似文献
3.
4.
5.
A patient who developed Hodgkin''s disease four years after infectious mononucleosis had elevated serum antibody titres to Epstein-Barr virus and delayed hypersensitivity reactions to membrane antigens prepared from fresh autologous spleen, from spleen cells of another Hodgkin''s patient, and from cell lines known to carry the Epstein-Barr virus genome. Additional studies in more lymphoma patients will be needed to determine the significance of the reactivity against tumour and virus-associated antigens which has been documented in this patient. 相似文献
6.
7.
Ai?Kia Yip Katsuhiko Iwasaki Chaitanya Ursekar Hiroaki Machiyama Mayur Saxena Huiling Chen Ichiro Harada Keng-Hwee Chiam Yasuhiro Sawada 《Biophysical journal》2013,104(1):19-29
Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we report traction stress measurements carried out using fibroblasts on polyacrylamide gels with Young’s moduli ranging from 6 to 110 kPa. We prepared the substrates by employing a modified method that involves N-acryloyl-6-aminocaproic acid (ACA). ACA allows for covalent binding between proteins and elastomers and thus introduces a more stable immobilization of collagen onto the substrate when compared to the conventional method of using sulfo-succinimidyl-6-(4-azido-2-nitrophenyl-amino) hexanoate (sulfo-SANPAH). Cells remove extracellular matrix proteins off the surface of gels coated using sulfo-SANPAH, which corresponds to lower values of traction stress and substrate deformation compared to gels coated using ACA. On soft ACA gels (Young’s modulus <20 kPa), cell-exerted substrate deformation remains constant, independent of the substrate Young’s modulus. In contrast, on stiff substrates (Young’s modulus >20 kPa), traction stress plateaus at a limiting value and the substrate deformation decreases with increasing substrate rigidity. Sustained substrate strain on soft substrates and sustained traction stress on stiff substrates suggest these may be factors governing cellular responses to substrate rigidity. 相似文献
8.
9.
10.