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1.
Sarah A. Nowak 《Biophysical journal》2009,96(7):2624-2636
Enveloped viruses enter host cells either through endocytosis, or by direct fusion of the viral envelope and the membrane of the host cell. However, some viruses, such as HIV-1, HSV-1, and Epstein-Barr can enter a cell through either mechanism, with the choice of pathway often a function of the ambient physical chemical conditions, such as temperature and pH. We develop a stochastic model that describes the entry process at the level of binding of viral glycoprotein spikes to cell membrane receptors and coreceptors. In our model, receptors attach the cell membrane to the viral membrane, while subsequent binding of coreceptors enables fusion. The model quantifies the competition between fusion and endocytotic entry pathways. Relative probabilities for each pathway are computed numerically, as well as analytically in the high viral spike density limit. We delineate parameter regimes in which fusion or endocytosis is dominant. These parameters are related to measurable and potentially controllable quantities such as membrane bending rigidity and receptor, coreceptor, and viral spike densities. Experimental implications of our mechanistic hypotheses are proposed and discussed. 相似文献
2.
Chicken gizzard tropomyosin was digested with carboxypeptidase A at the weight ratios of enzyme to substrate 1:200 and 1:50. Removal of about 16 C-terminal amino acid residues per tropomyosin molecule, at lower enzyme concentration, caused reversion of the effect on skeletal actomyosin ATPase activity from activating to inhibiting without an influence on polymerizability and actin-binding ability. Removal of about 26 C-terminal amino acid residues per molecule, at higher enzyme concentration, resulted in loss of polymerizability and actin binding ability. Digestion of gizzard tropomyosin with carboxypeptidase A has no dramatic effect on its binding to troponin T. The results show that not only the existence of head-to-tail overlapping regions but also their length is important for the functional properties of chicken gizzard tropomyosin. 相似文献
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S. P. Kharitonov D. E. Nowak A. I. Nowak N. A. Egorova S. A. Korkina D. V. Osipov O. V. Natal’skaya 《Biology Bulletin》2009,36(5):469-478
Red-breasted goose colonies have been studied near Medusa Bay (73°21′N, 80°32′E), on the northwestern Taimyr Peninsula, and
along the Agapa River (70°11′N, 86°15′E) down to its mouth (71°26′N, 89° 13′E), in the central Taimyr Peninsula. Red-breasted
geese nesting near peregrine falcons are protected by the falcons from arctic foxes; however, they are sometimes attacked
by the falcons themselves. In the colonies near peregrine falcon nests, the vast majority of goose nests were situated no
farther than 100 m from the falcon nest. When food is abundant, falcons protect a larger area around their nest. The distance
between the falcon nest and the surrounding goose nests is inversely related to the falcon’s activity. In years of higher
falcon activity, falcons prevent red-breasted geese from nesting as close to their nest as in years of lower falcon activity.
Additional stimuli are required for red-breasted geese to form colonies near rough-legged buzzard nests. The distance between
snowy owl nests and red-breasted goose nests was smaller when arctic foxes were abundant than when they were scarce. 相似文献
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In stationary cultures of Trametes versicolor seven proteinase bands were revealed by electrophoresis in mycelium and five in the medium. Under conditions of nitrogen starvation the number of bands in mycelium was unchanged whereas one extracellular proteinase was missing. In the case of carbon starvation one new intracellular proteinase activity appeared and one extracellular activity disappeared. Moreover, in all starved cultures distinct differences in the intensity of particular bands were observed. 相似文献
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Y S Fan R L Eddy M G Byers L L Haley W M Henry N J Nowak T B Shows 《Cytogenetics and cell genetics》1989,52(1-2):83-84
The gene for the human mineralocorticoid receptor (MLR) was previously localized to chromosome 4. Here, we have localized this gene to 4q31.2 by in situ hybridization. This precise mapping of MLR will assist in the linkage analysis and genetic characterization of pseudohypoaldosteronism, an autosomal recessive disorder which likely results from a defect in the MLR gene. 相似文献
10.
The interaction of ADP-stimulated human platelets with human 125I-fibrinogen as well as with pig and bovine fibrinogens was analysed. It was found that the fibrinogens studied were bound to the same platelet receptors but the affinity of animal preparations was about half the value observed for human fibrinogen (in a homologous system). 相似文献