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1.
Huie M. J.; Casazza G. A.; Horning M. A.; Brooks G. A. 《Journal of applied physiology》1996,80(5):1554-1559
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Daniel R. Brooks Gerardo Prez‐Ponce De Len Virginia Len‐Rggnon 《Zoologica scripta》2000,29(3):237-246
Species allocated to the digenean genera Enenterum Linton, 1910 ; Jeancadenatia Dollfus, 1946 ; Cadenatella Dollfus, 1946 ; and Koseiria form a clade within the Lepocreadiidae whose sister group is a clade comprising Neoallolepidapedon Yamaguti, 1965, Callogonotrema , Oshmarin, 1965, Allolepidapedon Yamaguti, 1940, and Bulbocirrus Oshmarin, 1965. Phylogenetic analysis of the Enenterinae based on comparative morphology, produced one most parsimonious tree with a consistency index of 0.72. Cadenatella is paraphyletic. Only 15.3% of character changes are evolutionary losses, supporting earlier reports that parasitic platyhelminths have experienced little secondary simplification during their evolutionary history. The Enenterinae appears to have originated in the Pacific Ocean, becoming associated with kyphosid fishes as a result of an ancient host switch. Subsequent evolutionary diversification reflects widespread geographical dispersal, consistent with the natural history of kyphosids. 相似文献
4.
Nearly 1.3 million total joint replacement procedures are performed in the United States annually, with numbers projected to rise exponentially in the coming decades. Although finite infection rates for these procedures remain consistently low, device-related infections represent a significant cause of implant failure, requiring secondary or revision procedures. Revision procedures manifest several-fold higher infection recurrence rates. Importantly, many revision surgeries, infected or not, require bone void fillers to support the host bone and provide a sufficient tissue bed for new hardware placement. Antibiotic-eluting bone void fillers (ABVF), providing both osteoconductive and antimicrobial properties, represent one approach for reducing rates of orthopedic device-related infections. Using a solvent-free, molten-cast process, a polymer-controlled antibiotic-eluting calcium carbonate hydroxyapatite (HAP) ceramic composite BVF (ABVF) was fabricated, characterized, and evaluated in vivo using a bacterial challenge in a rabbit radial defect window model. ABVF loaded with tobramycin eliminated the infectious burden in rabbits challenged with a clinically relevant strain of Staphylococcus aureus (inoculum as high as 107 CFU). Histological, microbiological, and radiographic methods were used to detail the effects of ABVF on microbial challenge to host bone after 8 weeks in vivo. In contrast to the HAP/BVF controls, which provided no antibiotic protection and required euthanasia 3 weeks post-operatively, tobramycin-releasing ABVF animals showed no signs of infection (clinical, microbiological, or radiographic) when euthanized at the 8-week study endpoint. ABVF sites did exhibit fibrous encapsulation around the implant at 8 weeks. Local antibiotic release from ABVF to orthopedic sites requiring bone void fillers eliminated the periprosthetic bacterial challenge in this 8-week in vivo study, confirming previous in vitro results. 相似文献
5.
Robert T. Brooks 《Biodiversity and Conservation》2011,20(11):2537-2541
White-nose syndrome (WNS) was first reported in a hibernating bat population in central New York State in February 2006. Since
2006, WNS has been reported from bat hibernacula across much of eastern United States and adjacent Canada and has been associated
with a dramatic decline in the populations of hibernating bats in the northeastern U.S. We are only beginning to discover
how these declines are manifest in changes in summer bat abundance and activity at local scales. A 3-year (2004–2006) acoustic
survey showed that the forested watershed of the Quabbin Reservoir in central Massachusetts supported an abundant and species-rich
summer bat community. In 2010, 4-years following the initial occurrence of WNS, a re-survey of the same habitats and sites
found a 72% reduction in bat activity on the watershed. This is the identical rate of decline reported from cave hibernacula
surveys (73%). This decline in summer activity levels is most likely a consequence of WNS-caused mortality. The impacts of
population losses of this magnitude of a once widespread and abundant taxa are unknown but are presumed to be ecologically
significant. 相似文献
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The quality of milk products is threatened by the formation of biofilms of thermophilicstreptococci on the internal surfaces of plate heat exchangers used in milk processing. Althoughattachment to stainless steel surfaces is one of the first stages in the development of a biofilm, themechanisms involved in attachment have not been reported. The cell surface properties of 12strains of thermophilic streptococci were examined to determine their importance in attachment tostainless steel surfaces. Hydrophobicity, extracellular polysaccharide production and cell surfacecharge varied between the different strains but could not be related to numbers attaching. Treatingthe cells with sodium metaperiodate, lysozyme or trichloroacetic acid to disrupt cell surfacepolysaccharide had no effect on attachment. Treatment with trypsin or sodium dodecyl sulphate toremove cell surface proteins resulted in a 100-fold reduction in the number of bacteria attaching.This result suggests that the surface proteins of the thermophilic streptococci are important intheir attachment to stainless steel. 相似文献
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S F Brooks T Herget S Broad E Rozengurt 《The Journal of biological chemistry》1992,267(20):14212-14218
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Glycosylated haemoglobin (HbA1) was measured in seven insulin-dependent diabetic patients before, during, and after a seven-day period of monitored poor control. There was considerable individual variation in the pattern and degree of change in HbA1 concentration induced by poor control and the time when it occurred. Greater increases in HbA1 were seen during the period of metabolic derangement than in the subsequent two months. More information is required before HbA1 estimations are widely used clinically to monitor control in individual diabetics. 相似文献