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An exponential-phase culture of E. coli responded to the addition of H2O2 by a decrease in DNA supercoiling induced by the lowering of the energy status of cells, potassium leakage, and breaking of polynucleotide chains. Extending the time of exposure of E. coli cells to hydrogen peroxide led to an increase in the intracellular pools of putrescine and potassium, promotion of cellular energy status, and the restoration of DNA supercoiling to values much in excess of the prestress level. The subsequent stabilization of the intracellular putrescine pool was accompanied by a release of this polyamine from the cell. Based on these results and those available in the literature, a mechanism of E. coli adaptation to oxidative stress is suggested that assigns roles to putrescine, potassium, and cellular energy status. 相似文献
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Mapping of the silver fox genes: assignments of the genes for ME1, ADK, PP, PEPA, GSR, MPI, and GOT1
T B Nesterova N B Rubtsov S M Zakian V G Matveeva A S Graphodatsky 《Cytogenetics and cell genetics》1991,56(2):125-127
Evidence is presented for the assignment of seven fox genes on the basis of the segregation data for chromosomes and enzymes of fox x Chinese hamster somatic cell hybrids. The chromosomal loci of the following enzyme genes were determined: ME1, VFU1; ADK and PP, VFU4; PEPA, VFU5; GSR, VFU7; and MPI and GOT1, VFU15. The localization of these genes now extends the fox genetic map to 22 mapped genes. Based on comparative analysis of mammalian genetic maps, karyotype evolution in Carnivora is discussed. 相似文献
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Some properties of cyclic AMP-dependent pig brain protein kinase were studied. The holoenzyme was shown to exist in solution in the form of a tetramer complex R2C2 with mol. weight of 180 000. The limited proteolysis of the regulatory subunit caused the formation of a fragment with mol. weight of 35 000, capable of independent binding of 3H-cyclic AMP and containing a site, which can be phosphorylated in the autophosphorylation reaction. Autophosphorylation of the holoenzyme led to an increase in the degree of dissociation of the former into individual subunits under the effect of cyclic AMP. The ability of the phosphoform of the catalytic subunit was demonstrated. The autophosphorylation process and the phosphotransferase reaction involve the same active site of the catalytic subunit. 相似文献
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M V Nesterova A I Glukhov A G Aprikian E S Severin 《Biokhimii?a (Moscow, Russia)》1987,52(7):1150-1153
The phosphorylation of nuclear proteins of porcine brain cAMP-dependent protein kinase was studied. Some nuclear proteins after extraction from the nuclei served as substrates for protein kinase. Lysine-rich histones H1, H2a and H2b were found to accept phosphate during chromatin phosphorylation by cAMP-dependent protein kinase. Phosphorylation of intact nuclei revealed that in such a system only histone H1 is a substrate for cAMP-dependent protein kinase. In the presence of DNA the histones are phosphorylated by cAMP-dependent protein kinase in a different manner. It was concluded that DNA can determine the accessibility of protein substrates for the catalytic subunit of cAMP-dependent protein kinase. 相似文献
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