全文获取类型
收费全文 | 8375篇 |
免费 | 823篇 |
国内免费 | 2篇 |
出版年
2023年 | 43篇 |
2022年 | 33篇 |
2021年 | 165篇 |
2020年 | 102篇 |
2019年 | 136篇 |
2018年 | 159篇 |
2017年 | 161篇 |
2016年 | 268篇 |
2015年 | 401篇 |
2014年 | 448篇 |
2013年 | 562篇 |
2012年 | 597篇 |
2011年 | 586篇 |
2010年 | 376篇 |
2009年 | 337篇 |
2008年 | 479篇 |
2007年 | 474篇 |
2006年 | 429篇 |
2005年 | 419篇 |
2004年 | 414篇 |
2003年 | 380篇 |
2002年 | 364篇 |
2001年 | 113篇 |
2000年 | 99篇 |
1999年 | 116篇 |
1998年 | 112篇 |
1997年 | 83篇 |
1996年 | 87篇 |
1995年 | 70篇 |
1994年 | 55篇 |
1993年 | 66篇 |
1992年 | 77篇 |
1991年 | 59篇 |
1990年 | 51篇 |
1989年 | 52篇 |
1988年 | 38篇 |
1987年 | 45篇 |
1986年 | 35篇 |
1985年 | 42篇 |
1984年 | 44篇 |
1983年 | 47篇 |
1982年 | 44篇 |
1981年 | 29篇 |
1978年 | 33篇 |
1977年 | 26篇 |
1976年 | 28篇 |
1974年 | 28篇 |
1973年 | 32篇 |
1972年 | 26篇 |
1971年 | 28篇 |
排序方式: 共有9200条查询结果,搜索用时 15 毫秒
1.
Denise Risch Nicholas J. Gales Jason Gedamke Lars Kindermann Douglas P. Nowacek Andrew J. Read Ursula Siebert Ilse C. Van Opzeeland Sofie M. Van Parijs Ari S. Friedlaender 《Biology letters》2014,10(4)
For decades, the bio-duck sound has been recorded in the Southern Ocean, but the animal producing it has remained a mystery. Heard mainly during austral winter in the Southern Ocean, this ubiquitous sound has been recorded in Antarctic waters and contemporaneously off the Australian west coast. Here, we present conclusive evidence that the bio-duck sound is produced by Antarctic minke whales (Balaenoptera bonaerensis). We analysed data from multi-sensor acoustic recording tags that included intense bio-duck sounds as well as singular downsweeps that have previously been attributed to this species. This finding allows the interpretation of a wealth of long-term acoustic recordings for this previously acoustically concealed species, which will improve our understanding of the distribution, abundance and behaviour of Antarctic minke whales. This is critical information for a species that inhabits a difficult to access sea-ice environment that is changing rapidly in some regions and has been the subject of contentious lethal sampling efforts and ongoing international legal action. 相似文献
2.
Potential efficacy of zileuton, a 5-LOX inhibitor, was evaluated for the reduction of pulmonary adenomas in the A/J murine
model when administered via nose-only inhalation. Development of pulmonary adenomas was induced with benzo(a)pyrene. Animals were treated with a zileuton solution (5 mg/mL in 85:15 ethanol/water) either twice weekly or five times
a week via nose-only inhalation; The placebo solution (85:15 EtOH/H2O, no active) was also evaluated. Dose delivered was calculated to be 1.2 mg/kg per exposure for each zileuton group. After
20 weeks of treatment, surface tumors were enumerated and histologically assessed. A significant reduction in tumor count
was noted for both the twice weekly administration (40%) and the five times a week administration (59%). The data also showed
a significant reduction for the group, which received the placebo (approximately 58%). The treatment groups were also found
to have an impact on the histological stages of adenoma development. 相似文献
3.
4.
Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in CGNs (CGN-Itonic) is controversial. Earlier studies suggested that GoCs mediate a component of CGN-Itonic that is present only in preparations from immature rodents. However, more recent studies have detected a GoC-dependent component of CGN-Itonic in preparations of mature rodents. In addition, acute exposure to ethanol was shown to potentiate the GoC component of CGN-Itonic and to induce a parallel increase in spontaneous inhibitory postsynaptic current frequency at CGNs. Here, we tested the hypothesis that these effects of ethanol on GABAergic transmission in CGNs are mediated by inhibition of the Na+/K+-ATPase. We used whole-cell patch-clamp electrophysiology techniques in cerebellar slices of male rats (postnatal day 23–30). Under these conditions, we reliably detected a GoC-dependent component of CGN-Itonic that could be blocked with tetrodotoxin. Further analysis revealed a positive correlation between basal sIPSC frequency and the magnitude of the GoC-dependent component of CGN-Itonic. Inhibition of the Na+/K+-ATPase with a submaximal concentration of ouabain partially mimicked the ethanol-induced potentiation of both phasic and tonic GABAergic currents in CGNs. Modeling studies suggest that selective inhibition of the Na+/K+-ATPase in GoCs can, in part, explain these effects of ethanol. These findings establish a novel mechanism of action of ethanol on GABAergic transmission in the central nervous system. 相似文献
5.
6.
7.
The Wageningen Delivery of Functionality symposium covered all aspects involved with food structural design to arrive at high-quality
foods which meet demanding customer expectations and regulatory requirements. The symposium integrated aspects from the structural
organization of foods at molecular and supramolecular scales to dedicated techniques required to describe and visualize such
structures, the gastro-intestinal events and how to model these in a laboratory setting, and finally the impact those food
structures and ingredients have on the consumer’s physiology and on the human perception. As an interdisciplinary platform,
bringing together more than 160 researchers from academia and industry, the symposium meanwhile fulfills an important role
in the food science community. 相似文献
8.
9.
10.
We sought to determine whether the orexigenic hormone, ghrelin, is involved in the intrinsic regulation of food choice in rats. Ghrelin would seem suited to serve such a role given that it signals hunger information from the stomach to brain areas important for feeding control, including the hypothalamus and reward system (e.g. ventral tegmental area, VTA). Thus, in rats offered a choice of palatable foods (sucrose pellets and lard) superimposed on regular chow for 2 weeks, we explored whether acute central delivery of ghrelin (intracerebroventricular (ICV) or intra-VTA) is able to redirect their dietary choice. The major unexpected finding is that, in rats with high baseline lard intake, acute ICV ghrelin injection increased their chow intake over 3-fold, relative to vehicle-injected controls, measured at both 3 hr and 6 hr after injection. Similar effects were observed when ghrelin was delivered to the VTA, thereby identifying the VTA as a likely contributing neurobiological substrate for these effects. We also explored food choice after an overnight fast, when endogenous ghrelin levels are elevated, and found similar effects of dietary choice to those described for ghrelin. These effects of fasting on food choice were suppressed in models of suppressed ghrelin signaling (i.e. peripheral injection of a ghrelin receptor antagonist to rats and ghrelin receptor (GHSR) knock-out mice), implicating a role for endogenous ghrelin in the changes in food choice that occur after an overnight fast. Thus, in line with its role as a gut-brain hunger hormone, ghrelin appears to be able to acutely alter food choice, with notable effects to promote “healthy” chow intake, and identify the VTA as a likely contributing neurobiological substrate for these effects. 相似文献