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Intratracheal instillation of a novel NO/nucleophile adduct selectively reduces pulmonary hypertension 总被引:1,自引:0,他引:1
Brilli Richard J.; Krafte-Jacobs Brian; Smith Daniel J.; Roselle Dominick; Passerini Daniel; Vromen Amos; Moore Lori; Szabo Csaba; Salzman Andrew L. 《Journal of applied physiology》1997,83(6):1968-1975
Brilli, Richard J., Brian Krafte-Jacobs, Daniel J. Smith,Dominick Roselle, Daniel Passerini, Amos Vromen, Lori Moore, CsabaSzabó, and Andrew L. Salzman. Intratracheal instillation ofa novel NO/nucleophile adduct selectively reduces pulmonary hypertension. J. Appl. Physiol. 83(6):1968-1975, 1997.We examined the pulmonary and systemichemodynamic effects of administering soluble nitric oxide (NO) donorcompounds (NO/nucleophile adducts, i.e., NONOates) directly into thetrachea of animals with experimentally induced pulmonary hypertension.Steady-state pulmonary hypertension was created by using thethromboxane agonist U-46619. Yorkshire pigs were randomly assigned toone of four groups: group 1,intratracheal saline (control; n = 8);group 2, intratracheal sodiumnitroprusside (n = 6);group 3, intratracheal ethylputreanineNONOate (n = 6); andgroup 4, intratracheal2-(dimethylamino)-ethylputreanine NONOate (DMAEP/NO;n = 6). Pulmonary and systemichemodynamics were monitored after drug instillation.Group 4 had significant reductions in pulmonary vascular resistance index (PVRI) at all time points comparedwith steady state and compared with group1 (P < 0.05), whereas systemic vascular resistance index did not change. The meanchange in mean pulmonary arterial pressure in group4 was 33.1 ± 1.2% compared with +6.4 ± 1.3% in group 1 (P < 0.001), and the mean change inmean arterial pressure was 9.3 ± 0.7% compared with acontrol value of 0.9 ± 0.5%(P < 0.05). Groups 2 and 3 hadsignificant decreases in both PVRI and systemic vascular resistanceindex compared with steady state and with group1. In conclusion, intratracheal instillation of apolar-charged tertiary amine NONOate DMAEP/NO results in the selectivereduction of PVRI. Intermittent intratracheal instillation of selectiveNONOates may be an alternative to continuously inhaled NO in thetreatment of pulmonary hypertension. 相似文献
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H. M. C. Kemps R. W. M. Brouwers M. J. Cramer H. T. Jorstad E. P. de Kluiver R. A. Kraaijenhagen P. M. J. C. Kuijpers M. R. van der Linde E. de Melker S. F. Rodrigo R. F. Spee M. Sunamura T. Vromen M. E. Wittekoek 《Netherlands heart journal》2020,28(7):387-390
The ongoing coronavirus disease 2019 (COVID-19) crisis is having a large impact on acute and chronic cardiac care. Due to public health measures and t 相似文献
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T. Vromen R. F. Spee J. J. Kraal N. Peek M. M. van Engen-Verheul R. A. Kraaijenhagen H. J. H. Gijsbers H. M. C. Kemps 《Netherlands heart journal》2013,21(3):138-143
Purpose
To assess methods for determination of exercise intensity, and to investigate practice variation with respect to the contents, volume and intensity of exercise training programs in Dutch cardiac rehabilitation (CR) centres.Methods
A paper questionnaire was sent to all Dutch CR centres, consisting of 85 questions for patients with an acute coronary syndrome (ACS) or after coronary revascularisation (Group 1) and for patients with chronic heart failure (CHF, Group 2).Results
CR professionals from 45 centres completed the questionnaires (58 %). Symptom-limited exercise testing was used to determine exercise capacity in 76 % and 64 % of the CR centres in group 1 and group 2, respectively; in these centres, a percentage of the maximum heart rate was the most frequently used exercise parameter (65 % and 56 %, respectively). All CR centres applied aerobic training and the majority applied strength training (64 % in group 1 and 92 % in group 2, respectively). There was a considerable variation in training intensity for both aerobic and strength training, as well as in training volume (1–20 h and 1–18 h respectively).Conclusion
Among Dutch CR centres, considerable variation exists in methods for determination of exercise intensity. In addition, there is no uniformity in training volume and intensity. 相似文献4.
T. Vromen R. W. M. Brouwers H. T. Jorstad R. A. Kraaijenhagen R. F. Spee M. E. Wittekoek M. J. Cramer J. M. C. van Hal L. Hofstra P. M. J. C. Kuijpers E. C. de Melker S. F. Rodrigo M. Sunamura N. H. M. K. Uszko-Lencer H. M. Kemps 《Netherlands heart journal》2021,29(10):479
Cardiac rehabilitation (CR) has evolved as an important part of the treatment of patients with cardiovascular disease. However, to date, its full potential is fairly underutilised. This review discusses new developments in CR aimed at improving participation rates and long-term effectiveness in the general cardiac population. It consecutively highlights new or challenging target groups, new delivery modes and new care pathways for CR programmes. These new or challenging target groups include patients with atrial fibrillation, obesity and cardiovascular disease, chronic coronary syndromes, (advanced) chronic heart failure with or without intracardiac devices, women and frail elderly patients. Also, the current evidence regarding cardiac telerehabilitation and loyalty programmes is discussed as new delivery modes for CR. Finally, this paper discusses novel care pathways with the integration of CR in residual risk management and transmural care pathways. These new developments can help to make optimal use of the benefits of CR. Therefore we should seize the opportunities to reshape current CR programmes, broaden their applicability and incorporate them into or combine them with other cardiovascular care programmes/pathways. 相似文献
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Brouwers R. W. M. van Exel H. J. van Hal J. M. C. Jorstad H. T. de Kluiver E. P. Kraaijenhagen R. A. Kuijpers P. M. J. C. van der Linde M. R. Spee R. F. Sunamura M. Uszko-Lencer N. H. M. K. Vromen T. Wittekoek M. E. Kemps H. M. C. 《Netherlands heart journal》2020,28(9):443-451
Netherlands Heart Journal - Multidisciplinary cardiac rehabilitation (CR) reduces morbidity and mortality and increases quality of life in cardiac patients. However, CR utilisation rates are low,... 相似文献
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