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M. A. Kulikova N. V. Malyuchenko M. A. Timofeeva V. A. Shleptsova Yu. A. Shchegol’kova A. M. Vedyakov A. G. Tonevitskii 《Human physiology》2007,33(6):752-758
The review is focused on the molecular and genetic bases of human personality traits useful for predicting individual performance in sports. Dopamine receptor gene polymorphisms have been found to be associated with novelty seeking, reward dependence, persistence, etc. These facts demonstrate the importance of studies on the contributions of different gene variants characteristic of the dopamine system to the formation of the predisposition of an athlete to success in sports. 相似文献
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Candidate genes were selected to study genetic polymorphism in athletes. The frequency of the most significant polymorphic variants of genes was determined. In this work, approaches are described to using the findings for developing recommendations on improvement of work capacity during strenuous exercise. 相似文献
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Tonevitskii A. G. Agapov I. I. Malyuchenko N. V. Moisenovich M. M. Vedyakov A. M. 《Molecular Biology》2002,36(4):528-533
The sequence coding for the viscumin (mistletoe lectin I, MLI) A-chain (MLA) was cloned from Viscum album genomic DNA with the use of synthetic primers. This yielded three recombinant (r) MLA variants differing in the number of amino acid substitutions. The rMLA structure and properties were probed using monoclonal antibodies against native MLA. Native MLI B-chain (MLB) was shown to facilitate the rMLA folding. Native MLI and chimeric proteins consisting of rMLA and native MLB did not differ in their cytotoxicity toward 3T3 fibroblastoid cells. Residues were identified that are located in the MLB-contacting region and have a considerable effect on the immunochemical and cytotoxic properties of rMLA. 相似文献
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