全文获取类型
收费全文 | 3348607篇 |
免费 | 283501篇 |
国内免费 | 77292篇 |
出版年
2021年 | 45332篇 |
2020年 | 33648篇 |
2019年 | 41612篇 |
2018年 | 49082篇 |
2017年 | 43989篇 |
2016年 | 61900篇 |
2015年 | 83923篇 |
2014年 | 102404篇 |
2013年 | 144439篇 |
2012年 | 153285篇 |
2011年 | 153130篇 |
2010年 | 107196篇 |
2009年 | 101318篇 |
2008年 | 131788篇 |
2007年 | 132267篇 |
2006年 | 124580篇 |
2005年 | 116904篇 |
2004年 | 110599篇 |
2003年 | 104250篇 |
2002年 | 99357篇 |
2001年 | 96882篇 |
2000年 | 96883篇 |
1999年 | 81440篇 |
1998年 | 42394篇 |
1997年 | 39966篇 |
1996年 | 36286篇 |
1995年 | 35587篇 |
1994年 | 34588篇 |
1993年 | 32874篇 |
1992年 | 65750篇 |
1991年 | 63237篇 |
1990年 | 61091篇 |
1989年 | 60331篇 |
1988年 | 56234篇 |
1987年 | 53260篇 |
1986年 | 50347篇 |
1985年 | 52035篇 |
1984年 | 45809篇 |
1983年 | 40067篇 |
1982年 | 34054篇 |
1981年 | 31410篇 |
1980年 | 29290篇 |
1979年 | 42525篇 |
1978年 | 34998篇 |
1977年 | 32386篇 |
1976年 | 30497篇 |
1975年 | 32641篇 |
1974年 | 35664篇 |
1973年 | 35250篇 |
1972年 | 31007篇 |
排序方式: 共有10000条查询结果,搜索用时 921 毫秒
1.
2.
M Shadidy X Caubit R Olsen O M Seternes U Moens S Krauss 《Biochimica et biophysica acta》1999,1446(3):295-307
We have identified mouse and human FKBP60, a new member of the FKBP gene family. FKBP60 shares strongest homology with FKBP65 and SMAP. FKBP60 contains a hydrophobic signal peptide at the N-terminus, 4 peptidyl-prolyl cis/trans isomerase (PPIase) domains and an endoplasmic reticulum retention motif (HDEL) at the C-terminus. Immunodetection of HA-tagged FKBP60 in NIH-3T3 cells suggests that FKBP60 is segregated to the endoplasmic reticulum. Northern blot analysis shows that FKBP60 is predominantly expressed in heart, skeletal muscle, lung, liver and kidney. With N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as a substrate, recombinant GST-FKBP60 is shown to accelerate effectively the isomerization of the peptidyl-prolyl bond. This isomerization activity is inhibited by FK506. mFKBP60 binds Ca2+ in vitro, presumably by its C-terminal EF-hand Ca2+ binding motif, and is phosphorylated in vivo. hFKBP60 has been mapped to 7p12 and/or 7p14 by fluorescence in situ hybridization (FISH). 相似文献
3.
4.
5.
Squilla mantis hemocyanin is composed of two hexameric subunits but has electron microscopic profiles different from other bis-hexameric hemocyanins, e.g. Astacus and Homarus. We distinguished three different electron microscopic profiles of S. mantis hemocyanin: two sideviews and a topview. These profiles were studied using computer image alignment and correspondence analysis [Van Heel, M. and Frank, J. (1981) Ultramicroscopy 6, 187 - 194]. With the results of this analysis we were able to build a three-dimensional model for the quaternary structure of this hemocyanin. In this model the two hexamers are stacked in such a way that their hexagonal surfaces overlap to about 60% of their width. In the overlap area four subunits are arranged in two different interhexameric pairs, each forming a bridging area between the two hexamers. 相似文献
6.
7.
8.
A patient with chronic anemia is presented who radiologically showed prominent rugae of the stomach. Angiography demonstrated an arteriovenous malformation with a large feeding artery and prominent draining veins. 相似文献
9.
10.