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排序方式: 共有277条查询结果,搜索用时 644 毫秒
1.
T I Titova T N Sidorova S A Radkevich N G Antsiferova A F Moroz 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1985,(8):80-84
The influence of immunization with P. aeruginosa vaccine on the immune status of volunteer donors has been studied. Immunization with P. aeruginosa vaccine in doses of 0.5-0.5-1.0 ml at intervals of 7 days has been found to lead to the 13-fold increase of the titer of specific antibodies, lasting for 3-4 months, which ensures the possibility of obtaining anti-P. aeruginosa hyperimmune plasma with standard titers. The injection of P. aeruginosa vaccine to donors leads to the activation of humoral immunity simultaneously with the increase of the absolute and relative number of rosette-forming B-lymphocytes without essential changes in the amount of rosette-forming T-lymphocytes. 相似文献
2.
N Iu Sidorova V A Nikolaev A N Surovaia A L Zhuze G V Gurski? 《Molekuliarnaia biologiia》1991,25(3):706-717
Cystine peptide dimer (Lys-Gly-Val-Cys-Val-N2H2Dns)2 with S-S bridge was synthesized and its interactions with DNA and synthetic polynucleotides have been studied by optical spectroscopy methods. By recording fluorescent titration curves we have shown that the affinity of the peptide to different synthetic polynucleotides decreases in the order: poly(dG).poly(dC) greater than poly(dA).poly(dT) greater than poly(dGC).poly(dGC). The stability of complexes to increasing concentrations of NaCl diminishes in the same order. The association constant is about 20-fold greater for peptide binding to poly(dG).poly(dC) than to poly(dA).poly(dT). By using circular dichroism and fluorescence measurements we have shown that the peptide competes for the binding sites on DNA with two minor-groove binding antibiotics--distamycin A and sybiromycin. These results have suggested that the peptide also binds in the DNA minor groove. Investigation of the interactions between such peptides and DNA may be useful for constructing ligands with combined specificity to DNA. 相似文献
3.
The electroencephalographic and autonomic correlates of the mental reproduction of emotional states]
O A Sidorova M B Kostiunina M A Kulikov 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1991,41(5):891-898
The present study is devoted to the analysis of changes of bioelectrical and vegetative indices at mental reproduction of emotional states by man. Analysis is conducted of the data of mapping of intracortical interactions depending on the dynamics of R-R interval changes. Two stages of mental reproduction of emotions are revealed which are characterized by the presence of different centers of integration--in the frontal and temporal parts of the brain cortex. It is shown that at maximum emotional stress the integration center shifts from the frontal regions to the temporal region of the left hemisphere. 相似文献
4.
The frequency of skin-galvanic (SGR) and motor reactions was analyzed at recognition of human emotional state by mimics. 31 healthy persons and 54 patients with lesions of temporal and frontoparietal areas of both cerebral hemispheres were examined. It has been established that the process of recognition takes place by stages: at first - at intuitive level accompanied by SGR, and then at the level of making decision completed by a motor or verbal reaction. Efficiency of recognition at the first stage does not so much depend on lesion localization as at the second stage. Pathology of the left hemisphere affects mainly the stage of making decision, and of the right one - the process of recognition as a whole. 相似文献
5.
mtDNA diversity in rhesus monkeys reveals overestimates of divergence time and paraphyly with neighboring species 总被引:4,自引:0,他引:4
Reconstructions of the human-African great ape phylogeny by using
mitochondrial DNA (mtDNA) have been subject to considerable debate. One
confounding factor may be the lack of data on intraspecific variation. To
test this hypothesis, we examined the effect of intraspecific mtDNA
diversity on the phylogenetic reconstruction of another Plio- Pleistocene
radiation of higher primates, the fascicularis group of macaque (Macaca)
monkey species. Fifteen endonucleases were used to identify 10 haplotypes
of 40-47 restriction sites in M. mulatta, which were compared with similar
data for the other members of this species group. Interpopulational,
intraspecific mtDNA diversity was large (0.5%- 4.5%), and estimates of
divergence time and branching order incorporating this variation were
substantially different from those based on single representatives of each
species. We conclude that intraspecific mtDNA diversity is substantial in
at least some primate species. Consequently, without prior information on
the extent of genetic diversity within a particular species, intraspecific
variation must be assessed and accounted for when reconstructing primate
phylogenies. Further, we question the reliability of hominoid mtDNA
phylogenies, based as they are on one or a few representatives of each
species, in an already depauperate superfamily of primates.
相似文献
6.
A I Brusilovski? G N Krivosheina V A Golubev T P Sidorova 《T?Sitologii?a i genetika》1983,17(4):49-54
The content of X-sex chromatin was studied in the buccal epithelial cells of pregnant women with Rh-negative blood. It was found that in women with a titer of Rh antibodies the amount of cells with X-sex chromatin decreases. A clinical-cytological correlation in the mother-placenta-fetus system was traced in pregnant women with a Rh antibody titer. 相似文献
7.
The influence of medium acidity on the intensity of light-dependent antibacterial activity of chlorophyllides isolated from biomass of microscopic green alga Westella botryoides has been studied. This light-dependent antibacterial activity has been shown to be maximum at low pH values. The ability to suppress the bacterial growth under the action of light decreases in neutral and alkaline media. It has been concluded that the reason of increase of light-dependent antibacterial activity of chlorophyllides at low pH values is formation of pheophorbides out of them 相似文献
8.
9.
M. E. Palkeeva M. V. Sidorova A. S. Molokoedov A. A. Az’muko Zh. D. Bespalova T. V. Sharf E. N. Mamochkina E. E. Efremov M. M. Rogova N. A. Mironova K. A. Zykov S. P. Golitsyn 《Russian Journal of Bioorganic Chemistry》2013,39(3):252-258
Fragments corresponding to the 83–98 sequence of the first extracellular loop and to the 168–192 and 171–182 sequences of the second extracellular loop of the M2-muscarinic receptor (antibodies to this receptor could be markers of early symptoms of heart disorders) were synthesized by solid phase method using the Fmoc-SPPS strategy. A new conformational antigen with the natural location of the disulfide bridge was prepared by selective formation of disulfide bond between the corresponding cysteine residues in the synthe-sized peptides and characterized. The comparative analysis of reactivity of the synthesized peptides towards sera from patients which had no organic heart disease was performed. A new conformational antigen was effectively bound to the sera from patients with idiopathic arrhythmias, but without symptoms of organic heart disease. 相似文献
10.
Sidorova M. V. Palkeeva M. E. Avdeev D. V. Molokoedov A. S. Ovchinnikov M. V. Azmuko A. A. Serebryakova L. I. Veselova O. M. Studneva I. M. Pisarenko O. I. 《Russian Journal of Bioorganic Chemistry》2020,46(1):32-42
Russian Journal of Bioorganic Chemistry - The full-length rat galanin (GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-NH2, G29) was prepared by the solid phase peptide synthesis using the Fmoc-strategy. The peptide... 相似文献