排序方式: 共有6条查询结果,搜索用时 15 毫秒
1
1.
2.
3.
4.
Neelima P. Sidharthan Rodney F. Minchin Neville J. Butcher 《The Journal of biological chemistry》2013,288(48):34364-34374
Dopamine neurotoxicity is associated with several neurodegenerative diseases, and neurons utilize several mechanisms, including uptake and metabolism, to protect them from injury. Metabolism of dopamine involves three enzymes: monoamine oxidase, catechol O-methyltransferase, and sulfotransferase. In primates but not lower order animals, a sulfotransferase (SULT1A3) is present that can rapidly metabolize dopamine to dopamine sulfate. Here, we show that SULT1A3 and a closely related protein SULT1A1 are highly inducible by dopamine. This involves activation of the D1 and NMDA receptors. Both ERK1/2 phosphorylation and calcineurin activation are required for induction. Pharmacological agents that inhibited induction or siRNA targeting SULT1A3 significantly increased the susceptibility of cells to dopamine toxicity. Taken together, these results show that dopamine can induce its own metabolism and protect neuron-like cells from damage, suggesting that SULT1A3 activity may be a risk factor for dopamine-dependent neurodegenerative diseases. 相似文献
5.
Chakkalathara Venu Anju Neelesh Dahanukar Arya Sidharthan Kutty Ranjeet Rajeev Raghavan 《Journal of fish biology》2019,94(1):187-190
The first assessment of the demographics of Lagocephalus inermis, a species associated with pufferfish bites and fishing down the food web in the Arabian Sea, south-west coast of India, was performed based on length structured population dynamics of 1601 individuals caught in commercial fisheries. Analysis revealed that the current level of exploitation is 90% of the predicted exploitation producing maximum relative yield per recruit (Emax), suggesting high levels of exploitation with potential for significant negative consequences for trophic cascades. 相似文献
6.
1