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排序方式: 共有373条查询结果,搜索用时 46 毫秒
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Dr. Sherif M. H. Sanad Alshimaa A. M. Abdelsalam Aya A. Gamal Eldin Esraa H. Abdelfattah Fatma R. M. Hussein Nada G. Mohammed Nariman A. S. Taha Prof. Dr. Ahmed E. M. Mekky 《化学与生物多样性》2023,20(6):e202300546
An efficient protocol was adopted to efficiently prepare three new series of bis(pyrazolo[1,5-a]pyrimidines) linked to different spacers. The new bis(pyrazolo[1,5-a]pyrimidines) were prepared in 80–90 % yields by reacting the respective bis(enaminones) and 4-(4-substituted benzyl)-1H-pyrazole-3,5-diamines in pyridine at reflux temperature for 5–7 h. The new products showed a wide spectrum of antibacterial activity against six different bacterial strains. In general, propane- and butane-linked bis(pyrazolo[1,5-a]pyrimidines), which are attached to 3-(4-methyl- or 4-methoxybenzyl) units, had the best antibacterial activity with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values up to 2.5 and 5.1 μM, respectively. Additionally, the previous products demonstrated promising MurB inhibitory activity with IC50 values up to 7.2 μM. 相似文献
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M M Kader G Kamel M T Aziz M M Kenawy M M el-Sadani A Erfan K R Madwar N Sherif 《Acta biologica et medica Germanica》1975,34(9):1465-1469
Different blood lipid components were evaluated in obese and normal Egyptians. In obese, plasma levels of total lipoproteins, beta-lipoprotein, total cholesterol, triglycerides, and non-esterified fatty acids were found to be significantly elevated. The plasma levels of esterified cholesterol and phospholipids were found to be significantly reduced. Tertroxine caused a drop of the plasma level of total lipoproteins, beta lipoproteins and total cholesterol and rise of plasma level of non-esterified fatty acids. 相似文献
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Hassan A. Hemeg Ihab M. Moussa Sherin Ibrahim Turki M. Dawoud Jwaher H. Alhaji Ayman S. Mubarak Saleh A. Kabli Roua A. Alsubki Azza M. Tawfik Sherif A. Marouf 《Saudi Journal of Biological Sciences》2020,27(12):3221-3227
This study evaluates the antimicrobial effects of ethanolic extract of five herbal plants; Guava (Psidium guajava), Sage (Salvia officinalis), Rhamnus (Ziziphusspina Christi), Mulberry (Morusalba L.), and Olive (Oleaeuropaea L) leaves against several microbial population representing Gram positive, Gram negative and Mollicutes; S. aureus, E. coli, Pasteurella multocida, B. cereus, Salmonella Enteritidis and M. gallisepticum using standard agar disc diffusion technique and minimal inhibitory concentration (MIC). Different extracts reveal variable results against the microorganism under study. All extracts have no antibacterial potency for Mycoplasma gallisepticum except Psidium guajava. The results of minimal inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) of the extracts against the six bacteria ranged from 625 to 5000 μg/ml. The used herbal extract could inhibit the selected microorganism under study with variable minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). 相似文献
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Baioumy Asmaa Ali Swelim Hamdy Hamed Ibrahim Ahmed Adly Mohamed Fatma El-Sayed Marzouk Aleya Soliman El-Alfy Sherif Helmy 《Experimental & applied acarology》2021,85(2-4):331-354
Experimental and Applied Acarology - This study examined the acaricidal, histopathological and genotoxic effects of the entomopathogenic fungus Beauveria bassiana on engorged females of the fowl... 相似文献
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Yee?Him Cheung Tenzin Gayden Philippe?M. Campeau Charles?A. LeDuc Donna Russo Van-Hung Nguyen Jiancheng Guo Ming Qi Yanfang Guan Steffen Albrecht Brenda Moroz Karen?W. Eldin James?T. Lu Jeremy Schwartzentruber David Malkin Albert?M. Berghuis Sherif Emil Richard?A. Gibbs David?L. Burk Megan Vanstone Brendan?H. Lee David Orchard Kym?M. Boycott Wendy?K. Chung Nada Jabado 《American journal of human genetics》2013,92(6):996-1000
Infantile myofibromatosis (IM) is the most common benign fibrous tumor of soft tissues affecting young children. By using whole-exome sequencing, RNA sequencing, and targeted sequencing, we investigated germline and tumor DNA in individuals from four distinct families with the familial form of IM and in five simplex IM cases with no previous family history of this disease. We identified a germline mutation c.1681C>T (p.Arg561Cys) in platelet-derived growth factor receptor β (PDGFRB) in all 11 affected individuals with familial IM, although none of the five individuals with nonfamilial IM had mutations in this gene. We further identified a second heterozygous mutation in PDGFRB in two myofibromas from one of the affected familial cases, indicative of a potential second hit in this gene in the tumor. PDGFR-β promotes growth of mesenchymal cells, including blood vessels and smooth muscles, which are affected in IM. Our findings indicate p.Arg561Cys substitution in PDGFR-β as a cause of the dominant form of this disease. They provide a rationale for further investigations of this specific mutation and gene to assess the benefits of targeted therapies against PDGFR-β in aggressive life-threatening familial forms of the disease. 相似文献
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Abdulbasit?Musa?SeidEmail author Melkie?Edris?Yesuf Digsu?Negese?Koye 《International breastfeeding journal》2013,8(1):14