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Nasser A. Al-Shabib Fohad Mabood Husain Rais Ahmad Khan Mohammad Shavez Khan Mohammad Zubair Alam Firoz Ahmad Ansari Sameen Laeeq Mohammad Zubair Syed Ali Shahzad Javed Masood Khan Ali Alsalme Iqbal Ahmad 《Saudi Journal of Biological Sciences》2019,26(2)
Foodborne pathogens are one of the major cause of food-related diseases and food poisoning. Bacterial biofilms and quorum sensing (QS) mechanism of cell–cell communication have also been found to be associated with several outbreaks of foodborne diseases and are great threat to food safety. Therefore, In the present study, we investigated the activity of three tetrahedrally coordinated copper(I) complexes against quorum sensing and biofilms of foodborne bacteria. All the three complexes demonstrated similar antimicrobial properties against the selected pathogens. Concentration below the MIC i.e. at sub-MICs all the three complexes interfered significantly with the quorum sensing regulated functions in C. violaceum (violacein), P. aeruginosa (elastase, pyocyanin and alginate production) and S. marcescens (prodigiosin). The complexes demonstrated potent broad-spectrum biofilm inhibition in Pseudomonas aeruginosa, E. coli, Chromobacterium violaceum, Serratia marcescens, Klebsiella pneumoniae and Listeria monocytogenes. Biofilm inhibition was visualized using SEM and CLSM images. Action of the copper(I) complexes on two key QS regulated functions contributing to biofilm formation i.e. EPS production and swarming motility was also studied and statistically significant reduction was recorded. These results could form the basis for development of safe anti-QS and anti-biofilm agents that can be utilized in the food industry as well as healthcare sector to prevent food-associated diseases. 相似文献
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Abbasi Mohammad Asad Memon Zulfiqar A. Durrani Nouman M. Haider Waleej Laeeq Kashif Mallah Ghulam Ali 《Cluster computing》2021,24(3):2133-2160
Cluster Computing - Traditional wireless technologies have evolutionary converged to Internet of Thing (IoT) for devices and service interactions. In the past decade, the academia, industry 4.0 and... 相似文献
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M. Saleem Akhtar Abdul Asim Farooq Syed Aun Muhammad Laeeq Akbar Lodhi C. Sikandar Hayat M. Mushtaq Aziz 《Biological trace element research》2010,137(3):340-343
The aim of present study was to determine the changes of sodium, potassium, chloride, copper, and zinc in serum of Nili-Ravi
buffalo during pregnancy and lactation. The study was carried out on 25 Nili-Ravi buffaloes during March 2008 to February
2009 at Buffalo Research Institute, Pattoki, District Kasur. Blood samples were taken from each buffalo during early pregnancy
(Phase EP), i.e., between 1 and 3 months gestation, mid pregnancy (Phase MP), i.e., between 4 and 6 months gestation, late
pregnancy (Phase LP), i.e., between 7 and 10 months gestation, and during lactation (Phase LT). Serum sodium, potassium, and
chloride were determined on a clinical chemistry analyzer whereas copper and zinc were determined on an atomic absorption
spectrophotometer. The mean serum sodium, potassium, and chloride concentrations varied non-significantly (P > 0.05) during pregnancy and lactation. With advancing pregnancy, copper increased and was significantly high (P < 0.05) during late pregnancy whereas during lactation copper concentrations dropped significantly (P < 0.05). The zinc concentrations increased non-significantly during early and mid pregnancy. There were significant differences
(P < 0.05) in zinc concentrations during lactation compared with late pregnancy. This study demonstrates that concentrations
of serum sodium, potassium, and chloride remain unchanged during pregnancy and lactation whereas serum copper concentrations
increased and zinc concentrations decreased with advancing pregnancy because of the demand of the fetus at different periods
of pregnancy. 相似文献
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Comparative evaluation of antifungal action of tea tree oil,chlorhexidine gluconate and fluconazole on heat polymerized acrylic denture base resin – an in vitro study 下载免费PDF全文
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