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Yam (Dioscorea esculenta) starch was modified by carboxymethylation. The effect of reaction parameters, amount of sodium hydroxide (NaOH), amount
of sodium monochloroacetate (SMCA), and reaction time on the degree of substitution (DS) of carboxymethyl yam starch (CMS),
was studied using the Box–Behnken experimental design. Physicochemical and potency to be a tablet disintegrant of CMS were
evaluated. CMS with DS in the range of 0.08–0.19 were obtained. The results from regression analysis indicated that the most
important factor in controlling DS was the amount of NaOH followed by SMCA content and reaction time. However, high concentration
of NaOH and SMCA lowered the DS. The optimal conditions to achieve the highest DS (0.19) were found to be at molar ratios
of NaOH and SMCA to anhydroglucose unit of 1.80 and 2.35, respectively, and with the reaction time of 4.8 h. The swelling
power and viscosity of CMS increased with an increase in the degree of modification. CMS showed satisfying tablet disintegrant
properties. The tablets containing 1.0–4.0 % CMS disintegrated faster than 5 min. Hence carboxymethyl yam starch can be used
as an excellent tablet disintegrant in low concentration. 相似文献
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