排序方式: 共有1条查询结果,搜索用时 46 毫秒
1
1.
The goal of the present study was to develop and evaluate microsponge-based topical delivery system of mupirocin for sustained
release and enhanced drug deposition in the skin. Microsponges containing mupirocin were prepared by an emulsion solvent diffusion
method. The effect of formulation and process variables such as internal phase volume and stirring speed on the physical characteristics
of microsponges were examined on optimized drug/polymer ratio by 32 factorial design. The optimized microsponges were incorporated into an emulgel base. In vitro drug release, ex vivo drug deposition, and in vivo antibacterial activity of mupirocin-loaded formulations were studied. Developed microsponges were spherical and porous, and
there was no interaction between drug and polymer molecules. Emulgels containing microsponges showed desired physical properties.
Drug release through cellulose dialysis membrane showed diffusion-controlled release pattern and drug deposition studies using
rat abdominal skin exhibited significant retention of active in skin from microsponge-based formulations by 24 h. The optimized
formulations were stable and nonirritant to skin as demonstrated by Draize patch test. Microsponges-based emulgel formulations
showed prolonged efficacy in mouse surgical wound model infected with S. aureus. Mupirocin was stable in topical emulgel formulations and showed enhanced retention in the skin indicating better potential
of the delivery system for treatment of primary and secondary skin infections, such as impetigo, eczema, and atopic dermatitis. 相似文献
1