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Abdou Tchoukoua Narandulam Usukhbayar Ken-ichi Kimura Eunsang Kwon Hiroyuki Momma 《Bioscience, biotechnology, and biochemistry》2017,81(12):2261-2267
Four new oleanane-type saponins, macrostachyaosides A, B, C, and D (1–4) were isolated from the roots of Acacia macrostachya. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR data and HR-ESI-MS analyses. At concentrations of 100 μM of each compounds, none of the tested compounds caused a significant growth reduction against HL60 cells. 相似文献
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Shunya Takahashi Takahiro Kawano Natsumi Nakajima Yasuaki Suda Narandulam Usukhbayar Ken-ichi Kimura Hiroyuki Koshino 《Bioorganic & medicinal chemistry letters》2018,28(5):930-933
Polyozellin is a p-terphenyl compound which was isolated from Polyozellus multiplex, and exhibits an inhibitory activity against prolyl oligopeptidase (POP). Its structure was assigned as 1 having a p-terphenyl skeleton including a p-substituted dibenzofuran moiety by spectroscopic analyses and chemical means. This paper describes the total syntheses of the proposed structure 1 for polyozellin and its o-isomer 2, revising the structure of polyozellin to the latter. These syntheses involved a double Suzuki-Miyaura coupling using chlorophenylboronic acid as a common key building block, and Cu mediated Ullmann cyclization as key steps. The inhibitory activities of synthetic compounds against POP and cancer cells were also evaluated. 相似文献
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