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Anaya-Ramos Laura Díaz-Ruíz Araceli Ríos Camilo Mendez-Armenta Marisela Montes Sergio Aguirre-Vidal Yoshajandith García-Jiménez Sara Baron-Flores Veronica Monroy-Noyola Antonio 《Biometals》2021,34(6):1295-1311
BioMetals - Thallium (TI) is one of the most toxic heavy metals. Human exposure to Tl occurs through contaminated drinking water and from there to food, a threat to health. Recently, environmental... 相似文献
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Martínez-Salazar MF Almenares-López D García-Jiménez S Sánchez-Alemán MA Juantorena-Ugás A Ríos C Monroy-Noyola A 《Genes & nutrition》2011,6(4):361-368
The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and representing both sexes. Based on body mass index, 63 individuals were classified as obese and 64 as normal weight. The PON1-Q192R and PON1-L55M polymorphisms were determined by restriction fragment length polymorphism PCR analysis. Both arylesterase and paraoxonase activity levels were similar in both groups, whereas systolic pressure, triglyceride, total cholesterol, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, glucose, and insulin levels were higher in the obese group than in the normal-weight group (P < 0.05). An exception was the high-density lipoprotein cholesterol (HDL-C) levels, which were lower in the obese group (P < 0.05). Although the PON1-Q192R polymorphism was not associated with either group, the frequency of the homozygous L genotype for the PON1-L55M polymorphism was higher in the obese group than in the normal-weight group (P < 0.05). In conclusion, this study established a positive association between the PON1-L55M homozygous L genotype and obesity. 相似文献
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Pérez-Barrón Gabriela Montes Sergio Aguirre-Vidal Yoshajandith Santiago Marti Gallardo Elena Espartero José Luis Ríos Camilo Monroy-Noyola Antonio 《Neurochemical research》2021,46(11):2923-2935
Neurochemical Research - 3,4-Dihydroxyphenyl ethanol, known as hydroxytyrosol (HTy), is a phenylpropanoid found in diverse vegetable species. Several studies have demonstrated that HTy is a potent... 相似文献
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Rojas P Rojas C Ebadi M Montes S Monroy-Noyola A Serrano-García N 《Neurochemical research》2004,29(7):1417-1423
EGb761 produces reversible inhibition of both monoamine oxidase (MAO) isoforms in the central nervous system. 1-Methyl-4-phenylpyridinium (MPP+) neurotoxicity is prevented by treatment with the MAO inhibitor pargyline. We investigated EGb761's effect on striatal MAO activity during MPP+ neurotoxicity. C-57 black mice were pretreated with EGb761 (10 mg/kg) daily for 17 days followed by administration of MPP+ (0.72 mg/kg). MPP+ enhanced striatal MAO (30%) activity at 6 h, and EGb761 prevented this effect. MAO-B activity in striatum was enhanced (70%) 6 h after MPP+ administration and was reduced to almost normal levels in EGb761 + MPP+ group compared to MPP+ group. Pretreatment with EGb761 partially prevented (32%) the striatal dopamine-depleting effect of MPP+ and prevented the reduction in striatal tyrosine hydroxylase activity (100%). Results suggest that EGb761 supplements may be effective in reducing MAO activity as well as enhancement in dopamine metabolism, thereby preventing MPP+-neurotoxicity. 相似文献
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Araceli Díaz-Ruíz Camilo Ríos Joselyn Carvajal-Sotelo Alma Ortiz-Plata Gerardo Pavel Espino-Solis Marisela Méndez-Armenta Sergio Montes Antonio Monroy-Noyola 《Neurochemical research》2010,35(2):343-347
This study examined the neuroprotective ability of tetrapeptide l-Asp-Ala-His-Lys (DAHK) in permanent middle cerebral artery occlusion in rats. One DAHK dose (16 mg/kg) or saline solution
were i.v. administered 30 min after occlusion and neurological deficit was evaluated at 2, 24, 48, 72 and 96 h using Longa
scoring scale. The striatum infarction area was evaluated until 96 h after occlusion in both groups after staining with hematoxylin–eosin.
DAHK-treated group showed a significant (P < 0.05) protection of 70% of neurological deficit at 96 h after occlusion, in comparison with the control-group that showed
permanent neurological deficit. The DAHK-treated group showed a significant (P < 0.05) reduction of 52% infarction area in the striatum, as compared to control values. Results presented here support the
possible therapeutic application of DAHK as a neuroprotective agent in human patients with stroke, as the peptide is part
of human serum albumin, already being tested in clinical trials. 相似文献
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