全文获取类型
收费全文 | 294篇 |
免费 | 10篇 |
出版年
2022年 | 2篇 |
2021年 | 3篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 2篇 |
2016年 | 7篇 |
2015年 | 10篇 |
2014年 | 11篇 |
2013年 | 16篇 |
2012年 | 16篇 |
2011年 | 12篇 |
2010年 | 7篇 |
2009年 | 8篇 |
2008年 | 8篇 |
2007年 | 9篇 |
2006年 | 10篇 |
2005年 | 12篇 |
2004年 | 12篇 |
2003年 | 19篇 |
2002年 | 22篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 8篇 |
1997年 | 3篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 7篇 |
1991年 | 7篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1979年 | 5篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1970年 | 5篇 |
1969年 | 3篇 |
1968年 | 1篇 |
1967年 | 3篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有304条查询结果,搜索用时 15 毫秒
1.
Mitsue Haraguchi Mario Motidome Massayoshi Yoshida Otro R. Gottlieb 《Phytochemistry》1983,22(2):561-563
The trunk bark of Ocotea catharinensis yielded, besides the known bicyclo(3.2.1)octanoid neolignans canellin-C and 5′-methoxycanellin-C, two epimers rel-(1R,4S and 4R,5S,6R,7S,8R)-1-allyl-4,8-dihydroxy-3,5-dimethoxy-7-methyl-6-piperonyl-bicyclo(3.2.1)oct-2-enes and rel-(1R,5S,6R,7S,8R)-1-allyl-3,8-dihydroxy-5-methoxy-7-methyl-6-piperonyl-4-oxobicyclo(3.2.1)oct-2-ene. The hydrobenzofuranoid neolignans are represented by the equally novel (2S,3S,5R)-5-allyl-5,7-dimethoxy-3-methyl-2-piperonyl-2,3,5,6-tetrahydro-6-oxobenzofuran and (2R,3S,3aS)-3a-allyl-5,7-dimethoxy-3-methyl-2-piperonyl-2,3,3a,6-tetrahydro-6-oxobenzofuran. 相似文献
2.
Formation of Recombinants Between Nontransmissible Drug-Resistance Determinants and Transfer Factors 总被引:5,自引:2,他引:3 下载免费PDF全文
Susumu Mitsuhashi Mitsuo Kameda Kenji Harada Mitsue Suzuki 《Journal of bacteriology》1969,97(3):1520-1521
Noninfectious drug-resistance determinants acquired conjugal transmissibility by the formation of recombinants with transfer factors, suggesting the origin of R factors. 相似文献
3.
4.
The distribution density of opioid receptors in the brain of El mice (seizure-susceptible strain) was examined to determine the relation between seizures and the opioid system. Saturation curves and Scatchard plots of [3H]2-d-alamine-5-d-leucine enkephalin binding revealed that the opioid delta receptor density in adult El mice during interictal periods was significantly increased in the cerebral cortex, hippocampus, and septal area. It was further shown that the concentration of such receptors in 25-day-old El mice that had no seizures was also significantly increased in the hippocampus and septal area, with no changes in apparent affinities, as compared with in the corresponding regions in ddY mice (seizure-nonsusceptible strain; the mother strain of El). Such up-regulation of opioid receptors in the El mouse brain could result from deficits in endogenous opioid peptides, which could be associated with the pathogenesis of seizure diathesis in the El mouse. 相似文献
5.
Kazuo Yamamoto Chizu Ishida Mitsue Saito Yukiko Konami Toshiaki Osawa Tatsuro Irimura 《Glycoconjugate journal》1994,11(6):572-575
Maackia amurensis haemagglutinin (MAH) is a leguminous lectin which preferentially binds to a cluster of sialylatedO-linked carbohydrate chains (Konami Y, Yamamoto K, Osawa T, Irimura T (1994)FEBS Lett
342:334–38). In the present study a 950 bp cDNA clone encoding MAH was isolated from a cDNA library constructed from germinatedMaackia amurensis seeds. From the nucleotide sequence, MAH was predicted to consist of 285 amino acid residues containing a signal peptide of 29 amino acids. The results also confirmed our previous findings from the amino acid sequence analysis, which indicated that two highly conserved amino acid residues in all other well-known leguminous lectins were replaced in MAH. These residues were lysine-105 and aspartic acid-135. The corresponding amino acid residues in other leguminous lectins were glycine and asparagine, respectively. These differences were due to the presence of nucleotides AAA and GAT in place of AAT/C and GGA/T.Abbreviations MAH
Maackia amurensis haemagglutinin. 相似文献
6.
Endogenous methionine enkephalin may play an anticonvulsant role in the seizure-susceptible El mouse
Seiji Koide Hiroshi Onishi Masafumi Katayama Sakae Yamagami 《Neurochemical research》1993,18(12):1259-1262
After the intracisternal injection of three protease inhibitors which prevent the degradation of methionine enkephalin (amastatin, Des-Pro2-bradykinin, and phosphoramidon) and a mixture of these protease inhibitors, we investigated the effect on convulsive seizures in the seizure-susceptible El mouse. We also measured the cerebral methionine enkephalin content by high-performance liquid chromatography coupled with radioimmunoassay. Protease inhibitors significantly decreased both the incidence of seizures and the seizure score in El mice in a dose-dependent manner. This anticonvulsant effect was reversed by naloxone (2 mg/kg, sc). The cerebral methionine enkephalin content increased significantly after the administration of protease inhibitors in comparison with saline injection. These findings suggest that it was not protease inhibitors but instead increase of endogenous methionine enkephalin that reduced the incidence of seizures and the seizure score in El mice. Together with our previous data, the present findings support our hypothesis that a deficit in anticonvulsant endogenous methionine enkephalin is involved in the pathogenesis of seizures in the El mouse. 相似文献
7.
K Yamagami 《Seikagaku. The Journal of Japanese Biochemical Society》1992,64(12):1438-1444
8.
Iwao Koyama Haruo Yamagami Toyoyasu Kuwae Munetsugu Kurata 《Prostaglandins & other lipid mediators》1982,23(6):777-785
The release of 6-keto-prostaglandin F1α (6KF1α)_and of thromboxane B2 (TXB2) from cells were investigated using mouse peritoneal exudate cells (PECs) and non-cultured peritoneal macrophages. They were prepared by adhesion to glass dishes and incubated for 1 hr at 37°C in 5% Co2 in air. Both the percentage of spreading macrophages and the release of 6KF1α and TXb2 increased in proportion to the incubation time. 6KF1α and TXB2 were released from the macrophages, not from the non-adherent cells. When PECs were incubated in silicon-coated glass dishes, the spreading of macrophages was hardly detected and lower amounts of 6KF1α and TXB2 were released from these cells compared with cells incubated in non-treated glass dishes. These findings suggest that adhesion with the correlated spreading of macrophages on glass dishes serve as a considerable physical factor for the release of 6KF1α and TXB2. 相似文献
9.
10.
Toshihiro Hamajima Fumie Takahashi Koji Kato Yukihito Sugano Susumu Yamaki Daisuke Suzuki Ayako Moritomo Satoshi Kubo Koji Nakamura Kaoru Yamagami Koji Yokoo Hidehiko Fukahori 《Bioorganic & medicinal chemistry》2019,27(6):1056-1064
Chemical optimization of the 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (THPP) scaffold was conducted with a focus on cellular potency while maintaining high selectivity against PI3K isoforms. Compound 11f was identified as a potent, highly selective and orally available PI3Kδ inhibitor. In addition, 11f exhibited efficacy in an in vivo antibody production model. The desirable drug-like properties and in vivo efficacy of 11f suggest its potential as a drug candidate for the treatment of autoimmune diseases and leukocyte malignancies. 相似文献