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Feldmane Daina Druva-Lūsīte Ieva Pole Valentīna Butac Mădălina Maria Militaru Mădălina Missa Imants Meiere Diāna Rubauskis Edgars 《Journal of Plant Growth Regulation》2021,40(2):533-540
Journal of Plant Growth Regulation - Sour cherry ‘Latvijas Zemais’ (Prunus cerasus) is a promising dwarfing rootstock for sweet cherries in Latvia, but low growing rate of newly... 相似文献
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Codru?a-Romani?a Usein M?d?lina Militaru Violeta Cristea Monica Str?u? 《Memórias do Instituto Oswaldo Cruz》2014,109(2):189-196
For the first time, we used multilocus sequence typing (MLST) to understand how
Romanian group B streptococcus (GBS) strains fit into the global GBS population
structure. Colonising isolates recovered from adult human females were tested for
antibiotic resistance, were molecularly serotyped based on the capsular
polysaccharide synthesis (cps) gene cluster and further
characterised using a set of molecular markers (surface protein genes, pilus-encoded
islands and mobile genetic elements inserted in the scpB-lmb
intergenic region). Pulsed-field gel electrophoresis was used to complement the MLST
clonal distribution pattern of selected strains. Among the 55 strains assigned to six
cps types (Ia, Ib, II-V), 18 sequence types (STs) were identified
by MLST. Five STs represented new entries to the MLST database. The prevalent STs
were ST-1, ST-17, ST-19 and ST-28. Twenty molecular marker profiles were identified.
The most common profiles (rib+GBSi1+PI-1,
rib+GBSi1+PI-1, PI-2b and alp2/3+PI-1, PI-2a) were
associated with the cps III/ST-17 and cps V/ST-1
strains. A cluster of fluoroquinolone-resistant strains was detected among the
cps V/ST-19 members; these strains shared alp1
and IS1548 and carried PI-1, PI-2a or both. Our results
support the usefulness of implementing an integrated genotyping system at the
reference laboratory level to obtain the reliable data required to make comparisons
between countries. 相似文献
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Mihail Lucian Pascu Balazs Danko Ana Martins Nikoletta Jedlinszki Tatiana Alexandru Viorel Nastasa Mihai Boni Andra Militaru Ionut Relu Andrei Angela Staicu Attila Hunyadi Seamus Fanning Leonard Amaral 《PloS one》2013,8(2)
Introduction
Phenothiazines when exposed to white light or to UV radiation undergo a variety of reactions that result in degradation of parental compound and formation of new species. This process is slow and may be sped up with exposure to high energy light such as that produced by a laser.Methods
Varying concentrations of Chlorpromazine Hydrochloride (CPZ) (2–20 mg/mL in distilled water) were exposed to 266 nm laser beam (time intervals: 1–24 hrs). At distinct intervals the irradiation products were evaluated by spectrophotometry between 200–1500 nm, Thin Layer Chromatography, High Pressure Liquid Chromatography (HPLC) - Diode Array Detection, HPLC tandem mass spectrometry, and for activity against the CPZ sensitive test organism Staphylococcus aureus ATCC 25923.Results
CPZ exposure to 266 nm laser beam of given energy levels yielded species, whose number increased with duration of exposure. Although the major species produced were Promazine (PZ), hydroxypromazine or PZ sulfoxide, and CPZ sulfoxide, over 200 compounds were generated with exposure of 20 mg/mL of CPZ for 24 hrs. Evaluation of the irradiation products indicated that the bioactivity against the test organism increased despite the total disappearance of CPZ, that is due, most probably, to one or more new species that remain yet unidentified.Conclusions
Exposure of CPZ to a high energy (6.5 mJ) 266 nm laser beam yields rapidly a large number of new and stable species. For biological grade phenothiazines (in other words knowing the impurities in the samples: solvent and solute) this process may be reproducible because one can control within reasonably low experimental errors: the concentration of the parent compound, the laser beam wavelength and average energy, as well as the duration of the exposure time. Because the process is “clean” and rapid, it may offer advantages over the pyrogenically based methods for the production of derivatives. 相似文献4.
Crişan TO Farcaş MF Trifa AP Plantinga TS Militaru MS Pop IV Netea MG Popp RA 《Gene》2012,494(1):109-111
Toll-like receptors (TLRs) are critical components of the pathogen recognition by the host innate immune system. Recently it has been shown that TLR1 is under evolutionary pressure in Europeans. This involves the positive selection of the nonsynonymous TLR1 1805G variant in Europeans, although this is associated with poor TLR1 response and unfavorable prognosis in various infections. In terms of natural selection, differential fertility is another mechanism, independent of infection susceptibility, that may explain the polymorphism pattern observed for TLR1. To test this hypothesis, we assessed the correlation of two TLR1 SNPs (T1805G and G239C) with spontaneous pregnancy loss in a case-control study that included 132 spontaneous pregnancy loss patients and 142 control volunteers. Similar allele frequencies of T1805G were observed between cases and controls, but GG genotype tended to be associated with pregnancy loss (OR 1.91; 95%CI 1.03, 3.53). No differences were observed for the TLR1 G239C SNP. Our findings showed slight differences in the distribution of T1805G variants in women with pregnancy loss, but these were not indicative of a protective effect of the TLR1 1805G allele for this fertility disorder. Although our hypothesis was not proven, potential effects of TLR1 polymorphisms on pregnancy outcome have been suggested, and future studies in larger cohorts are warranted. 相似文献
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