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Thin-layer chromatography (TLC) of fecal bile acids has been used to confirm visual identification of scat samples found in Armenia in 2004–2005 and attributed to the leopard (Panthera pardus ciscaucasica). The results of TLC do not differ significantly from those of visual identification, confirming the reliability of the latter method. Taking into account the frequency and distribution of fresh scats, two priority areas for leopard conservation have been identified: the Central and Khachadzor districts of the Khosrov Reserve and the Nuvadi-Shvanidzor area in eastern Meghri Ridge. 相似文献
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Karen A. Malkhasyan Yousef Zakharia Mohammed Milhem 《Pigment cell & melanoma research》2017,30(6):511-520
For patients with metastatic melanoma, the emergence of immune checkpoint inhibitors and targeted BRAF and MEK inhibitors has markedly enhanced clinical outcomes compared with chemotherapy. However, these novel agents are also associated with unique sets of adverse events, and increased overall survival can lead to prolonged exposure to some novel agents. Therefore, clinical evaluation of these therapies has now included the analysis of health‐related quality of life (HRQoL) in addition to more traditional efficacy and safety outcomes as a measure of patient perception of benefit. The current review focuses on HRQoL outcomes in clinical trials of immune checkpoint inhibitors and targeted therapies in patients with advanced and metastatic melanoma to inform healthcare providers about patient perception of HRQoL as a new perspective in treatment decision making. 相似文献
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Pepoyan Astghik Z. Balayan Marine H. Malkhasyan Lilit Manvelyan Anahit Bezhanyan Tatevik Paronikyan Ruzanna Tsaturyan Vardan V. Tatikyan Stepan Kamiya Shigeru Chikindas Michael L. 《Probiotics and antimicrobial proteins》2019,11(3):905-909
Probiotics and Antimicrobial Proteins - Double-strand breaks in the DNA of the small intestine in male Wistar rats were studied using a neutral comet assay after 7 days of feeding with a... 相似文献
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Benjamin Bleyhl Marine Arakelyan Elshad Askerov Hendrik Bluhm Alexander Gavashelishvili Mamikon Ghasabian Arash Ghoddousi Aurel Heidelberg Igor Khorozyan Alexander Malkhasyan Karen Manvelyan Mohammadreza Masoud Ehsan M. Moqanaki Volker C. Radeloff Mahmood Soofi Paul Weinberg Nugzar Zazanashvili Tobias Kuemmerle 《Diversity & distributions》2019,25(1):129-141
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V. V. Salomashkina M. V. Kholodova U. A. Semenov A. S. Muradov A. Malkhasyan 《Russian Journal of Genetics》2017,53(1):108-117
We perform an analysis of the diversity of the control region fragment (570 bp) and ten nuclear microsatellite loci for 36 specimens of the brown bear (Ursus arctos) from several regions of the Caucasus. Four mitochondrial haplogroups that significantly differ from each other are revealed. An assumption of reiterative brown bear colonization of the Caucasus is made. Microsatellite data analysis shows a medium level of heterozygosity and clear differentiation between Caucasian and European bears combined with a slight distinction between the Caucasian regions. 相似文献
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