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1.
Ivanov VK Chekin SIu Kashcheev VV Maksiutov MA Tumanov KA Tsyb AF 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2011,51(1):41-48
Dynamics of the mortality and the mortality radiation risks among male emergency workers of 1986-1987 years of entrance to the Chernobyl zone is analyzed. The average dose of external gamma-exposure for this cohort equals 128 mGy. The size of the cohort at the beginning of the follow-up in 1992 was 47820 persons. For the follow-up period 1992-2006 statistically significant radiation risks of death rates have been estimated: for the mortality from all causes, the excess relative risk per Gy (ERR/Gy) equals 0.42 with 95% confidence interval (95% CI) (0.14-0.72); for the mortality from solid cancers ERR/Gy = 0.74, 95% CI (0.03-1.76); and for the mortality from the circulatory system diseases ERR/Gy = 1.01, 95% CI (0.51-1.57). Based on these estimates the risk groups were ranked among all Russian emergency workers (160 thousand persons): the group of the potential radiation risk with doses more than 150 mGy (33488 persons) and the group of the high radiation risk with doses more than 240 mGy (6054 persons). 相似文献
2.
Ivanov VK Tsyb AF Gorskiĭ AI Maksiutov MA Chekin SIu Petrov AV Tumanov KA Kashcheev VV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2006,46(2):159-166
The work focuses on the results of the analysis of the cancer incidence among the Chernobyl emergency workers residing in Russia during 1991-2001. The analysis is based on the data for the cohort of male emergency workers from 6 regions of Russia including 55718 persons with documented external radiation doses in the range of 0.001-0.3 Gy who worked within the 30-km zone in 1986-1987. The mean age at exposure for these persons was 34.8 years old and the mean external radiation dose 0.13 Gy. In this cohort 1370 cases of solid cancer were diagnosed. Three follow-up periods were considered: 1991-1995, 1996-2001 and 1991-2001. The second follow-up period was chosen to allow for a minimum latency period of 10 years. Risk assessments were performed for two control groups: the first control group ("external") represented incidence rates for corresponding ages in Russia in general and the second control group ("internal") consisted of emergency workers. The estimated standardized incidence ratio (SIR) is in good agreement with that of the control within 95% CI. The values of the excess relative risk per unit dose 1 Gy (ERR/Gy) for solid malignant neoplasms have been estimated to be 0.33 (95% CI: -0.39, 1.22) (internal control) for the follow-up period 1991-2001 and 0.19 (95% CI: -0.66, 1.27) for 1996-2001. The analysis of cancer morbidity was carried out for the cohort of 29003 emergency workers who took part in liquidation of the consequences of the Chernobyl accident from 26 April 1986 to 25 April 1987. It was shown that the excess relative risk of cancer deaths per unit dose 1 Sv (ERR/Sv) is equal to 1.52 (95% CI: 0.20, 2.85). 相似文献
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Victor K. Ivanov A. I. Gorsky V. V. Kashcheev M. A. Maksioutov K. A. Tumanov 《Radiation and environmental biophysics》2009,48(3):247-252
The paper presents estimates for the latent period of the induction of radiogenic solid cancers among Chernobyl emergency
workers (males) living in six central regions of Russia. The analysis is based on medical and dosimetry data gathered by the
National Radiation and Epidemiological Registry over the time period from 1986 to 2005. The cohort includes 59,770 persons
who stayed in the exposure zone (30-km zone around the Chernobyl nuclear power plant) in 1986–1987. There were 2,718 cases
of solid tumors identified during the follow-up time in this cohort. The mean radiation dose in the cohort is 0.13 Gy. The
radiation risk and latent period were estimated using the method of maximum likelihood. The excess relative risk per unit
dose was found to be 0.96 (95% confidence interval (CI): 0.3–1.7) and the minimum latent period for induction of solid tumors
is 4.0 years (95% CI: 3.3–4.9). 相似文献
5.
Aruna Kasoju M Lakshmi Narasu Charuvaka Muvva Bathula VV SubbaRao 《Bioinformation》2012,8(14):684-686
Aflatoxins are polyketide-derived secondary metabolites produced by Aspergillus spp. The toxic effects of aflatoxins have adverse
consequences for human health and agricultural economics. The aflR gene, a regulatory gene for aflatoxin biosynthesis, encodes a
protein containing a zinc-finger DNA-binding motif. AFLR-Protein three-dimensional model was generated using Robetta server.
The modeled AFLR-Protein was further optimization and validation using Rampage. In the simulations, we monitored the
backbone atoms and the C-α-helix of the modeled protein. The low RMSD and the simulation time indicate that, as expected, the
3D structural model of AFLR-protein represents a stable folding conformation. This study paves the way for generating computer
molecular models for proteins whose crystal structures are not available and which would aid in detailed molecular mechanism of
inhibition of aflatoxin. 相似文献
6.
Mark P. Little Tamara V. Azizova Dimitry Bazyka Simon D. Bouffler Elisabeth Cardis Sergey Chekin Vadim V. Chumak Francis A. Cucinotta Florent de Vathaire Per Hall John D. Harrison Guido Hildebrandt Victor Ivanov Valeriy V. Kashcheev Sergiy V. Klymenko Olivier Laurent Kotaro Ozasa Soile Tapio Andrew M. Taylor Ioanna Tzoulaki Wendy L. Vandoolaeghe Richard Wakeford Lydia Zablotska Wei Zhang Steven E. Lipshultz 《Radiation and environmental biophysics》2013,52(1):157-159
7.
Visualization of molecular structures aids in the understanding of structural and functional roles of biological macromolecules.
Macromolecular transport between the cell nucleus and cytoplasm is facilitated by the nuclear pore complex (NPC). The ring
structure of the NPC is large and contains several distinct proteins (nucleoporins) which function as a selective gate for the passage
of certain molecules into and out of the nucleus. In this note we demonstrate the utility of a python code that allows direct
mapping of the physiochemical properties of the constituent nucleoporins on the scaffold of the yeast NPC׳s cytoplasmic view. We
expect this tool to be useful for researchers to visualize the NPC based on their physiochemical properties and how it alters when
specific mutations are introduced in one or more of the nucleoporins. The code developed using Python is available freely from the
authors. 相似文献
8.
Ivanov VK Chekin SY Kashcheev VV Maksioutov MA Tumanov KA 《Radiation and environmental biophysics》2008,47(4):463-467
The presented paper deals with the thyroid cancer incidence in selected cohorts of emergency workers of Russia. In 1986-2003, a total of 87 cases of thyroid cancer were observed. Based on these data, a statistically significant increase in thyroid cancer incidence was found above the reference level for the male population of Russia, corresponding to a standardized incidence rate (SIR) of SIR = 3.47 [95% confidence interval (CI): 2.80; 4.25]. The highest incidence rate (SIR = 6.62, 95% CI: 4.63; 9.09) was shown for those emergency workers who took part in the early recovery operations in April-July 1986. The estimated SIR value increases to 7.97 (95% CI: 5.24; 11.52) after allowing for a 10 years latent period of Chernobyl-related thyroid cancers. These results indicate that the exposure to incorporated (131)I was the major risk factor of thyroid cancer among Chernobyl emergency workers. No statistically significant relationship was found for the thyroid cancer incidence and external radiation dose. 相似文献
9.
Ivanov VK Tsyb AF Khait SE Kashcheev VV Chekin SY Maksioutov MA Tumanov KA 《Radiation and environmental biophysics》2012,51(2):143-149
Of all potentially radiogenic cancers, leukemia, a type of cancer of the blood, has the highest risk attributable to ionizing
radiation. Despite this, the quantitative estimation of radiation risk of a leukemia demands studying very large exposed cohorts,
because of the very low level of this disease in unexposed populations and because of the tendency for its radiation risk
to decrease with time. At present, the Japanese cohort of atomic bomb survivors is still the primary source of data that allows
analysis of radiation-induced leukemia and the underlying dose–response relationship. The second large cohort that would allow
to study radiation-induced leukemia is comprised of individuals who were exposed due to the accident of the Chernobyl nuclear
power plant in 1986. The objective of the present study was to estimate radiation risks of leukemia incidence among the Russian
cohort of Chernobyl emergency workers, for different time periods after the accident. Twenty-five years after the Chernobyl
accident and based on the results of the present study, one can conclude that the radiation risk of leukemia incidence derived
from the Russian cohort of Chernobyl emergency workers is similar to that derived from the cohort of atomic bomb survivors:
The time-averaged excess relative risk per Gray (ERR Gy−1) equals 4.98 for the Russian cohort and 3.9 for the life span study (LSS) cohort; excess absolute risk decreases with time
after exposure at an annual rate of 9% for the Russian cohort, and of 6.5% for the LSS cohort. Thus, the excess in risk of
leukemia incidence in a population due to a single exposure is restricted in time after exposure by the period of about 15 years. 相似文献
10.
VV. R. PHILIPSON F.L.S. 《Botanical journal of the Linnean Society. Linnean Society of London》1987,95(1):19-25
Problems presented by genera, or small groups of genera, which have been given family rank are reviewed, and the genera are divided into a number of categories according to the closeness of their affinity to other genera or families. Satellite genera that stand in close relation to families should be united with them. Binary families, that have been divided into two (or more) related families, should be re–united. Families connected by linking genera, should, logically, be united but practical considerations usually prevent this. Clusters of diverse but more or less distantly related genera present unusual problems, being treated either as several, often monogeneric families or as a loosely structured family. Truly isolated genera must be given family and often ordinal rank. 相似文献