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1.
Kaloustian S Wann BP Bah TM Falcao S Dufort AM Ryvlin P Godbout R Rousseau G 《Apoptosis : an international journal on programmed cell death》2007,12(11):1945-1951
Reperfused myocardial infarction induces an inflammatory response that is responsible for local and systemic alterations.
Among these, apoptosis observed in the amygdala following myocardial infarction has been pointed out as a consequence of such
an inflammatory process. We hypothesized that inhibition of the inducible inflammatory enzyme Cox-2 during the reperfusion
period may attenuate the apoptotic process in the amygdala. Anaesthetized rats were subjected to left anterior descending
coronary artery occlusion for 40 min, followed by reperfusion. The Cox-2 antagonist Celecoxib (3 mg/kg i.p.) was administered
10 min after the onset of the reperfusion period. After 72 h of reperfusion, infarct size was determined and the lateral and
medial amygdala were dissected from the brain. Infarct size was similar between untreated and Celecoxib-treated animals (40–45%
of the area at risk). Cox-2 expression was significantly reduced in both parts of the amygdala in the Celecoxib group. Apoptosis
regression was observed in the amygdala of the Celecoxib group as shown by decreased number of TUNEL positive cells and by
decreased of caspase-3 activation. Bax/Bcl-2 ratio was not significantly altered by Celecoxib while Akt activation was increased
in the lateral amygdala but not in the medial amygdala. This data indicates that inhibition of Cox-2 by Celecoxib is associated
with regression of apoptosis in the amygdala following myocardial infarction. 相似文献
2.
Vazken M. Der Kaloustian Shirine H. Idriss-Daouk Ruwayda T. Hallal Z. L. Awdeh 《Biochemical genetics》1974,12(1):51-58
The method of isoelectric focusing in polyacrylamide gel was used to separate G6PD isozymes in crude hemolysates of human, rabbit, and rat erythrocytes. G6PD (B) from erythrocytes of a normal human male donor revealed six bands of activity. Their mean isoelectric points, using pH 3–10 and 5–8 range empholytes, were pI 7.04 for band I, pI 6.60 for band II, pI 6.37 for band III, pI 6.11 for band IV, pI 5.94 for band V, pI 5.79 for band VI. G6PD from rabbit and rat erythrocytes revealed completely different multiple band patterns. The method of isoelectric focusing in polyacrylamide gel is presented as a new way of detecting G6PD isozyme patterns. 相似文献
3.
Pedro LC Pinheiro João CR Cardoso Ana S Gomes Juan Fuentes Deborah M Power Adelino VM Canário 《BMC evolutionary biology》2010,10(1):373
Background
Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) belong to a family of endocrine factors that share a highly conserved N-terminal region (amino acids 1-34) and play key roles in calcium homeostasis, bone formation and skeletal development. Recently, PTH-like peptide (PTH-L) was identified in teleost fish raising questions about the evolution of these proteins. Although PTH and PTHrP have been intensively studied in mammals their function in other vertebrates is poorly documented. Amphibians and birds occupy unique phylogenetic positions, the former at the transition of aquatic to terrestrial life and the latter at the transition to homeothermy. Moreover, both organisms have characteristics indicative of a complex system in calcium regulation. This study investigated PTH family evolution in vertebrates with special emphasis on Xenopus and chicken. 相似文献4.
An electrophoretic method for detecting hypoxanthine-guanine phosphoribosyl transferase variants 总被引:6,自引:0,他引:6
Vazken M. Der Kaloustian Raymond Byrne William J. Young Barton Childs 《Biochemical genetics》1969,3(3):299-302
An electrophoretic method that detects hypoxanthine-guanine phosphoribosyl transferase variants is described.Aided by National Institutes of Health Grants HD 00486, HD 00004, GM 14155, and AM 10813. 相似文献
5.
6.
Background
Although direct infiltration of papillary carcinoma of thyroid to larynx, trachea and esophagus is well recognized, lymphatic and vascular metastases to larynx and hypopharynx have rarely been reported. 相似文献7.
Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23 总被引:26,自引:0,他引:26 下载免费PDF全文
Bork JM Peters LM Riazuddin S Bernstein SL Ahmed ZM Ness SL Polomeno R Ramesh A Schloss M Srisailpathy CR Wayne S Bellman S Desmukh D Ahmed Z Khan SN Kaloustian VM Li XC Lalwani A Riazuddin S Bitner-Glindzicz M Nance WE Liu XZ Wistow G Smith RJ Griffith AJ Wilcox ER Friedman TB Morell RJ 《American journal of human genetics》2001,68(1):26-37
8.
Sandhoff disease: a prevalent form of infantile GM2 gangliosidosis in Lebanon. 总被引:3,自引:2,他引:1 下载免费PDF全文
V M Der Kaloustian M J Khoury R Hallal Z H Idriss M E Deeb N W Wakid F S Haddad 《American journal of human genetics》1981,33(1):85-89
All cases clinically diagnosed as Tay-Sachs disease at the American University Hospital, Beirut, during a period of 22 years (1957--1979) were reviewed. Of a total of 15 cases, seven had serum hexosaminidase tested and proved to have Sandhoff disease. In two other cases, parents were tested and found to be Sandhoff carriers. These results indicate that Sandhoff disease is relatively prevalent in Lebanon and that it may represent the more common form of infantile GM2 gangliosidosis in this country. 相似文献
9.
Cyanobacterium Anacystis nidulans R2, Synechocystis sp. PCC 6803 (wild-type strain and mutants Delta2 and Delta3 lacking PSII and PSI, respectively), and Synechocystis sp. BO 9201 synthesize the pigment--protein complex CP36 (CPIV-4, CP43') under iron deficiency in the medium. Accumulation of CP36 is accompanied by structural reorganizations in the photosynthetic membranes. Integrating mean times of excitation relaxation (quenching) are 2.2 nsec (CP36), 1 nsec (PSI), and 420 psec (PSII in Fm state). The energy migration between CP36 and the photosystems can be described by a model of a one-layer ring of CP36 around core-complexes. The excitation from CP36 to PSI is transferred within <10 psec. The energy transfer from CP36 to PSII occurs during 170 psec. Cells with low content of CP36 probably contain only a latent fraction of unbound to phycobilisomes PSII which is the analog of PSIIbeta of higher plants. In PSI there are four binding sites for CP36 monomers per RC. PSII can bind up to 32 molecules of CP36 per RC. Cells with a large amount of CP36 contain monomer form of PSII core-complex which can bind eight tetramers of CP36 (8 binding sites). In conditions of iron deficiency only one monomer of a dimer PSII core-complex is destroyed and released chlorophyll is accumulated in CP36. Accumulation of CP36 in A. nidulans cells can be accompanied by membrane stacking which is similar to the stacking in chlorophyll b-containing organisms. The stacking can occur in the region of localization of PSII latent fraction bound to CP36. The membrane stacking shields PSII stromal surfaces from the aqueous phase for activation of electron transfer on the acceptor side of PSII. 相似文献
10.
Cytogenetic studies were performed on a severely mentally retarded adolescent with multiple congenital abnormalities (congenital heart disease, cryptorchidism and infantilism, rocker bottom feet and eye abnormalities). He had a complex rearrangement as a result of three breaks of chromosome 3 and two breaks of chromosome 5, and haphazard reunion of the fragments. This complex rearrangement appears balanced. The loss of very small chromosome fragments is perhaps the cause of the dysmorphia. The possibility of position effect is discussed. 相似文献