9.
Reoccurrence of infectious diseases and ability of pathogens to resist antibacterial action has raised enormous challenges which may possibly be confronted by nanotechnology routes. In the present study, uniformly embedded silver nanoparticles in orthorhombic nanotubes of lithium vanadium oxide (LiV
2O
5/Ag) were explored as an impeder of bacterial growth and biofilm. The LiV
2O
5/Ag nanocomposites have impeded growth of Gram-positive
Bacillus subtilis NCIM 2063 and Gram-negative
Escherichia coli NCIM 2931 at 60 to 120 μg/mL. It also impeded the biofilm in
Pseudomonas aeruginosa NCIM 2948 at 12.5 to 25 μg/mL. Impedance in the growth and biofilm occurs primarily by direct action of the nanocomposites on the cell surfaces of test organisms as revealed by surface perturbation in scanning electron microscopy. As the metabolic growth and biofilm formation phenomena of pathogens play a central role in progression of pathogenesis, LiV
2O
5/Ag nanocomposite-based approach is likely to curb the menace of reoccurrence of infectious diseases. Thus, LiV
2O
5/Ag nanocomposites can be viewed as a promising candidate in biofabrication of biomedical materials.
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