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Summary The microbial degradation of organic sulfur compounds was examined in aerobic conditions employing a pure culture of aPseudomonas sp., isolated from the soil. The effect ofn-alkanes on the degradation of dibenzothiophene (DBT) showed that the assimilation of the sulfur compound by the microorganism is favoured byn-dodecane. Moreover, the saturated fraction was seen to enhance the degradation of the sulfur compounds to be found in a deasphaltenated heavy oil. 相似文献
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Robert M. Stefani Sofia Barbosa Andrea R. Tan Stefania Setti Aaron M. Stoker Gerard A. Ateshian Ruggero Cadossi Gordana Vunjak-Novakovic Roy K. Aaron James L. Cook J. Chloë Bulinski Clark T. Hung 《Biotechnology and bioengineering》2020,117(5):1584-1596
Articular cartilage injuries are a common source of joint pain and dysfunction. We hypothesized that pulsed electromagnetic fields (PEMFs) would improve growth and healing of tissue-engineered cartilage grafts in a direction-dependent manner. PEMF stimulation of engineered cartilage constructs was first evaluated in vitro using passaged adult canine chondrocytes embedded in an agarose hydrogel scaffold. PEMF coils oriented parallel to the articular surface induced superior repair stiffness compared to both perpendicular PEMF (p = .026) and control (p = .012). This was correlated with increased glycosaminoglycan deposition in both parallel and perpendicular PEMF orientations compared to control (p = .010 and .028, respectively). Following in vitro optimization, the potential clinical translation of PEMF was evaluated in a preliminary in vivo preclinical adult canine model. Engineered osteochondral constructs (∅ 6 mm × 6 mm thick, devitalized bone base) were cultured to maturity and implanted into focal defects created in the stifle (knee) joint. To assess expedited early repair, animals were assessed after a 3-month recovery period, with microfracture repairs serving as an additional clinical control. In vivo, PEMF led to a greater likelihood of normal chondrocyte (odds ratio [OR]: 2.5, p = .051) and proteoglycan (OR: 5.0, p = .013) histological scores in engineered constructs. Interestingly, engineered constructs outperformed microfracture in clinical scoring, regardless of PEMF treatment (p < .05). Overall, the studies provided evidence that PEMF stimulation enhanced engineered cartilage growth and repair, demonstrating a potential low-cost, low-risk, noninvasive treatment modality for expediting early cartilage repair. 相似文献
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Rémy C. Lemoine Ann C. Petersen Lina Setti Jutta Wanner Andreas Jekle Gabrielle Heilek André deRosier Changhua Ji Pamela Berry David Rotstein 《Bioorganic & medicinal chemistry letters》2010,20(2):704-708
Replacement of a secondary amide with an N-acyl or N-sulfonyl gem-disubstituted azacyle in a series of CCR5 antagonists led to the identification of compounds with excellent in vitro HIV antiviral activity and increased intrinsic membrane permeability. 相似文献
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CD8+ CD28- T regulatory lymphocytes inhibiting T cell proliferative and cytotoxic functions infiltrate human cancers 总被引:1,自引:0,他引:1
Filaci G Fenoglio D Fravega M Ansaldo G Borgonovo G Traverso P Villaggio B Ferrera A Kunkl A Rizzi M Ferrera F Balestra P Ghio M Contini P Setti M Olive D Azzarone B Carmignani G Ravetti JL Torre G Indiveri F 《Journal of immunology (Baltimore, Md. : 1950)》2007,179(7):4323-4334
Tumor growth is allowed by its ability to escape immune system surveillance. An important role in determining tumor evasion from immune control might be played by tumor-infiltrating regulatory lymphocytes. This study was aimed at characterizing phenotype and function of CD8+ CD28- T regulatory cells infiltrating human cancer. Lymphocytes infiltrating primitive tumor lesion and/or satellite lymph node from a series of 42 human cancers were phenotypically studied and functionally analyzed by suppressor assays. The unprecedented observation was made that CD8+ CD28- T regulatory lymphocytes are almost constantly present and functional in human tumors, being able to inhibit both T cell proliferation and cytotoxicity. CD4+ CD25+ T regulatory lymphocytes associate with CD8+ CD28- T regulatory cells so that the immunosuppressive activity of tumor-infiltrating regulatory T cell subsets, altogether considered, may become predominant. The infiltration of regulatory T cells seems tumor related, being present in metastatic but not in metastasis-free satellite lymph nodes; it likely depends on both in situ generation (via cytokine production) and recruitment from the periphery (via chemokine secretion). Collectively, these results have pathogenic relevance and implication for immunotherapy of cancer. 相似文献
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Rama Jain Michelle Mathur Jiong Lan Abran Costales Gordana Atallah Savithri Ramurthy Sharadha Subramanian Lina Setti Paul Feucht Bob Warne Laura Doyle Stephen Basham Anne B. Jefferson Brent A. Appleton Mika Lindvall Cynthia M. Shafer 《Bioorganic & medicinal chemistry letters》2018,28(19):3197-3201
Utilizing the already described 3,4-bi-aryl pyridine series as a starting point, incorporation of a second ring system with a hydrogen bond donor and additional hydrophobic contacts yielded the azaindole series which exhibited potent, picomolar RSK2 inhibition and the most potent in vitro target modulation seen thus far for a RSK inhibitor. In the context of the more potent core, several changes at the phenol moiety were assessed to potentially find a tool molecule appropriate for in vivo evaluation. 相似文献
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David M. Rotstein Stephen D. Gabriel Ferenc Makra Lubov Filonova Shelley Gleason Christine Brotherton-Pleiss Lina Q. Setti Alejandra Trejo-Martin Eun Kyung Lee Surya Sankuratri Changhua Ji Andre deRosier Marianna Dioszegi Gabrielle Heilek Andreas Jekle Pamela Berry Paul Weller Cheng-I. Mau 《Bioorganic & medicinal chemistry letters》2009,19(18):5401-5406
A novel series of CCR5 antagonists has been identified, utilizing leads from high-throughput screening which were further modified based on insights from competitor molecules. Lead optimization was pursued by balancing opposing trends of metabolic stability and potency. Selective and potent analogs with good pharmacokinetic properties were successfully developed. 相似文献
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A study of the granulometric, mineralogical and chemical composition of surface sediments and suspended particulate matter in the coastal area between Varazze and Cape Noli (Ligurian Sea), provided useful information on transport and sedimentation processes in the area. Sediments samples from the shelf were highly heterogeneous, ranging from pelites to sands. Minerals typical of individual river basins were found close to river mouths, indicating a limited sediment transport along the coast. Chemical and textural characteristics of the suspended particulate matter indicated that the longshore sediment transport is influenced by the presence of a submarine canyon; material coming from the east, following the Ligurian current, is partially diverted offshore along the canyon axis. The coastline pattern, some harbor artifacts, and the peculiar morphology of the shelf are all factors controlling the direction of sediment transport. 相似文献