排序方式: 共有49条查询结果,搜索用时 46 毫秒
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Julie Chaumeil Mariann Micsinai Panagiotis Ntziachristos Ludovic Deriano Joy M.-H. Wang Yanhong Ji Elphege P. Nora Matthew J. Rodesch Jeffrey A. Jeddeloh Iannis Aifantis Yuval Kluger David G. Schatz Jane A. Skok 《Cell reports》2013,3(2):359-370
Highlights? RAG-dependent monoallelic loop formation is linked to monoallelic RAG cleavage ? RAG enrichment, cleavage, and higher-order loop formation occur at the 3′ end of Tcra ? Looping out is a determinant of directed RAG targeting ? ATM-mediated control of looping out is linked to the maintenance of genome stability 相似文献
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Ito Y Arai S van Oers NS Aifantis I von Boehmer H Miyazaki T 《Journal of immunology (Baltimore, Md. : 1950)》2002,169(9):4913-4919
It has been of much interest whether there is functional redundancy between the constitutively signaling pre-Talpha/TCRbeta (pre-TCR) and ligated TCRalphabeta complexes, which independently operate the two distinct checkpoints during thymocyte development, i.e., the pre-TCR involved in beta-selection at the CD4(-)CD8(-) double-negative stage and the TCRalphabeta being crucial for positive/negative selection at the CD4(+)CD8(+) double-positive stage. We found that the pre-TCR expressed on double-positive cells in TCRalpha-deficient (TCRalpha(-/-)) mice produced a small number of mature CD8(+) T cells. Surprisingly, when pre-Talpha was overexpressed, resulting in augmentation of pre-TCR expression, there was a striking increase of the CD8(+) T cells. In addition, even in the absence of up-regulation of pre-TCR expression, a similar increase of CD8(+) T cells was also observed in TCRalpha(-/-) mice overexpressing Egr-1, which lowers the threshold of signal strength required for positive selection. In sharp contrast, the CD8(+) T cells drastically decreased in the absence of pre-Talpha on a TCRalpha(-/-) background. Thus, the pre-TCR appears to functionally promote positive selection of CD8(+) T cells. The biased production of CD8(+) T cells via the pre-TCR might also support the potential involvement of signal strength in CD4/CD8 lineage commitment. 相似文献
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One of the main regulators of gene expression during embryogenesis and stem cell differentiation is DNA methylation. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its specialized enzymatic machinery and to understand the biological significance of 5hmC. The recent discovery of recurrent deletions and somatic mutations in the TET gene family, which includes proteins that can hydroxylate methylcytosine (5mC), in a large fraction of myeloid malignancies further suggested a key role for dynamic DNA methylation changes in the regulation of stem cell differentiation and transformation. 相似文献
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A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis
that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis
pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current
knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper
subset (Th17) that promotes osteoclast formation and activation. 相似文献
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