全文获取类型
收费全文 | 2667篇 |
免费 | 229篇 |
国内免费 | 2篇 |
出版年
2021年 | 27篇 |
2020年 | 35篇 |
2019年 | 34篇 |
2018年 | 57篇 |
2017年 | 42篇 |
2016年 | 58篇 |
2015年 | 89篇 |
2014年 | 115篇 |
2013年 | 117篇 |
2012年 | 147篇 |
2011年 | 149篇 |
2010年 | 73篇 |
2009年 | 72篇 |
2008年 | 125篇 |
2007年 | 106篇 |
2006年 | 119篇 |
2005年 | 94篇 |
2004年 | 129篇 |
2003年 | 99篇 |
2002年 | 114篇 |
2001年 | 36篇 |
2000年 | 26篇 |
1999年 | 30篇 |
1998年 | 37篇 |
1997年 | 20篇 |
1996年 | 33篇 |
1995年 | 29篇 |
1994年 | 30篇 |
1993年 | 26篇 |
1992年 | 20篇 |
1991年 | 20篇 |
1990年 | 20篇 |
1989年 | 25篇 |
1988年 | 27篇 |
1987年 | 18篇 |
1986年 | 22篇 |
1985年 | 26篇 |
1984年 | 20篇 |
1983年 | 30篇 |
1982年 | 23篇 |
1981年 | 21篇 |
1980年 | 22篇 |
1979年 | 16篇 |
1978年 | 21篇 |
1974年 | 14篇 |
1973年 | 17篇 |
1972年 | 14篇 |
1964年 | 14篇 |
1954年 | 15篇 |
1953年 | 16篇 |
排序方式: 共有2898条查询结果,搜索用时 125 毫秒
1.
2.
Hugh S. Keeping Peter H. Jellinck 《Biochimica et Biophysica Acta (BBA)/General Subjects》1980,632(2):150-158
Iodide administered in the drinking water for 5–7 days increased the activity of estradiol-induced uterine peroxidase in the immature rat. This effect was specific for iodide and could not be mimicked by chloride, bromide, thiocyanate, perchlorate or iodate. Sodium iodide also increased peroxidase activity in the parotid gland but had no effect on glucose-6-phosphate dehydrogenase in the uterus, thyroid or parotid even though estradiol produced a 2-fold increase in the activity of this enzyme in the uterus. 125I was taken up more readily by the uterus than by muscle but this process was not influenced by prior treatment of the animals with estrogen. The in vitro effect of sulfhydryl reagents on uterine peroxidase was also investigated and proposals made for possible mechanisms of action of iodide on this enzyme in the intact animal. 相似文献
3.
Jonathan D. Nickels Joseph E. Curtis Hugh O’Neill Alexei P. Sokolov 《Journal of biological physics》2012,38(3):497-505
Recent studies have discovered strong differences between the dynamics of nucleic acids (RNA and DNA) and proteins, especially at low hydration and low temperatures. This difference is caused primarily by dynamics of methyl groups that are abundant in proteins, but are absent or very rare in RNA and DNA. In this paper, we present a hypothesis regarding the role of methyl groups as intrinsic plasticizers in proteins and their evolutionary selection to facilitate protein dynamics and activity. We demonstrate the profound effect methyl groups have on protein dynamics relative to nucleic acid dynamics, and note the apparent correlation of methyl group content in protein classes and their need for molecular flexibility. Moreover, we note the fastest methyl groups of some enzymes appear around dynamical centers such as hinges or active sites. Methyl groups are also of tremendous importance from a hydrophobicity/folding/entropy perspective. These significant roles, however, complement our hypothesis rather than preclude the recognition of methyl groups in the dynamics and evolution of biomolecules. 相似文献
4.
Kainate receptors (KARs) are a class of ionotropic glutamate receptors that are expressed throughout the central nervous system. The function and subcellular localization of KARs are tightly regulated by accessory proteins. We have previously identified the single-pass transmembrane proteins, Neto1 and Neto2, to be associated with native KARs. In the hippocampus, Neto1, but not Neto2, controls the abundance and modulates the kinetics of postsynaptic KARs. Here we evaluated whether Neto2 regulates synaptic KAR levels in the cerebellum where Neto1 expression is limited to the deep cerebellar nuclei. In the cerebellum, where Neto2 is present abundantly, we found a ∼40% decrease in GluK2-KARs at the postsynaptic density (PSD) of Neto2-null mice. No change, however, was observed in total level of GluK2-KARs, thereby suggesting a critical role of Neto2 on the synaptic localization of cerebellar KARs. The presence of a putative class II PDZ binding motif on Neto2 led us to also investigate whether it interacts with PDZ domain-containing proteins previously implicated in regulating synaptic abundance of KARs. We identified a PDZ-dependent interaction between Neto2 and the scaffolding protein GRIP. Furthermore, coexpression of Neto2 significantly increased the amount of GRIP associated with GluK2, suggesting that Neto2 may promote and/or stabilize GluK2:GRIP interactions. Our results demonstrate that Neto2, like Neto1, is an important auxiliary protein for modulating the synaptic levels of KARs. Moreover, we propose that the interactions of Neto1/2 with various scaffolding proteins is a critical mechanism by which KARs are stabilized at diverse synapses. 相似文献
5.
6.
7.
8.
Willoughby de Broke Rudyard Kipling Hugh Elliot E. Ray Lankester Leonard Hill Laurence R. Philipps Wm. Arbuthnot Lane James Crichton-Browne H. Bryan Donkin Francis Lloyd R. A. Lyster John MacAlister F. W. Mott William Osler C. W. Saleeby J. H. Sequeira Humphry Rolleston Hugh Wansey Bayly 《BMJ (Clinical research ed.)》1919,2(3074):725
9.
10.