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排序方式: 共有150条查询结果,搜索用时 62 毫秒
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G. M. Alder B. M. Austen C. L. Bashford A. Mehlert C. A. Pasternak 《Bioscience reports》1990,10(6):509-518
Human heat shock protein (hsp) 70 and bacterial protein groEL promote leakage of calcein from liposomes induced by human serum albumin signal peptide, byS. aureus toxin or by diphtheria toxin. Hsp 70 and groEL, as well as two mycobacterial homologues hsp 71 and hsp 65, induce ion conducting pores across planar lipid bilayers at low or neutral pH. It is concluded that hsp induce pores in membranes and that this may contribute to their action within cells. 相似文献
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Haemolysis by Sendal virus, -toxin, and activated complement is inhibited by high concentrations of divalent cations. In Daudi cells, sublytic amounts of these agents induce the following changes: collapse of surface membrane potential, uptake of Na+ and loss of K+ from cells, and leakage of phosphorylated metabo-tites from cells. The changes induced by Sendal virus and complement are sensitive to physiological concentrations of extracellular Ca2+. It is concluded that fluctuations in plasma Ca2+ concentration may affect the damaging action of certain pore-forming agents on susceptible cells. 相似文献
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Alder Keleman Jon Hellin Dagoberto Flores 《Human ecology: an interdisciplinary journal》2013,41(5):683-705
Discussions of maize agriculture in Mexico often treat “maize” as a uniform commodity, sold in a relatively homogeneous market, and for which there is a single, “economically rational” production strategy. Based on qualitative research on maize value chains, we suggest that this unitary notion entails significant oversimplifications. We offer a heuristic model of farm-size related “profitability crossover,” based on observations of highland maize varieties’ roles within a series of farm-cycle opportunities and constraints. We suggest that while improved maize varieties may be profitable for large-scale farms taking advantage of economies of scale, landrace cultivation may offer advantages to small- to medium-scale farmers, who utilize a diverse range of input strategies, and sell their products in specialty markets. Understanding maize agriculture as a multi-product and multi-market pursuit rather than uniform commodity production would add greater depth to policy and academic debates. 相似文献
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Gianpiero Di Leva Claudia Piovan Pierluigi Gasparini Apollinaire Ngankeu Cristian Taccioli Daniel Briskin Douglas G. Cheung Brad Bolon Laura Anderlucci Hansjuerg Alder Gerard Nuovo Meng Li Marilena V. Iorio Marco Galasso Santhanam Ramasamy Guido Marcucci Danilo Perrotti Kimerly A. Powell Anna Bratasz Michela Garofalo Kenneth P. Nephew Carlo M. Croce 《PLoS genetics》2013,9(3)
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Environmental context and magnitude of disturbance influence trait‐mediated community responses to wastewater in streams 下载免费PDF全文
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Davis DR McAlpine JB Pazoles CJ Talbot MK Alder EA White C Jonas BM Murray BE Weinstock GM Rogers BL 《Journal of molecular microbiology and biotechnology》2001,3(2):179-184
Using bioinformatics approaches, 34 potential multidrug resistance (MDR) transporter sequences representing 4 different transporter families were identified in the unannotated Enterococcus faecalis database (TIGR). A functional genomics campaign generating single-gene insertional disruptions revealed several genes whose absence confers significant hypersensitivities to known antimicrobials. We constructed specific strains, disrupted in a variety of previously unpublished, putative MDR transporter genes, as tools to improve the success of whole-cell antimicrobial screening and discovery. Each of the potential transporters was inactivated at the gene level and then phenotypically characterized, both with single disruption mutants and with 2-gene mutants built upon a delta norA deleted strain background. 相似文献
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Patrick D. Brandt Susi Sturzenegger Varvayanis Tracey Baas Amanda F. Bolgioni Janet Alder Kimberly A. Petrie Isabel Dominguez Abigail M. Brown C. Abigail Stayart Harinder Singh Audra Van Wart Christine S. Chow Ambika Mathur Barbara M. Schreiber David A. Fruman Brent Bowden Christopher A. Wiesen Yvonne M. Golightly Chris E. Holmquist Daniel Arneman Joshua D. Hall Linda E. Hyman Kathleen L. Gould Roger Chalkley Patrick J. Brennwald Rebekah L. Layton 《PLoS biology》2021,19(7)