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Gunga HC Kirsch K Rocker L 《Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology》1996,3(2):1-4
Changes in erythropoietin levels in the blood were measured under several experimental conditions. Subjects were exposed to either bedrest, isolation and confinement, head-down tilt, or space flight. Results indicated that production and release of erythropoietin were decreased following simulated weightlessness and in some space flown subjects. The authors conclude that the responses are much more individual in space than during simulation experiments. 相似文献
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P. Martin Sander Andreas Christian Marcus Clauss Regina Fechner Carole T. Gee Eva‐Maria Griebeler Hanns‐Christian Gunga Jürgen Hummel Heinrich Mallison Steven F. Perry Holger Preuschoft Oliver W. M. Rauhut Kristian Remes Thomas Tütken Oliver Wings Ulrich Witzel 《Biological reviews of the Cambridge Philosophical Society》2011,86(1):117-155
The herbivorous sauropod dinosaurs of the Jurassic and Cretaceous periods were the largest terrestrial animals ever, surpassing the largest herbivorous mammals by an order of magnitude in body mass. Several evolutionary lineages among Sauropoda produced giants with body masses in excess of 50 metric tonnes by conservative estimates. With body mass increase driven by the selective advantages of large body size, animal lineages will increase in body size until they reach the limit determined by the interplay of bauplan, biology, and resource availability. There is no evidence, however, that resource availability and global physicochemical parameters were different enough in the Mesozoic to have led to sauropod gigantism. We review the biology of sauropod dinosaurs in detail and posit that sauropod gigantism was made possible by a specific combination of plesiomorphic characters (phylogenetic heritage) and evolutionary innovations at different levels which triggered a remarkable evolutionary cascade. Of these key innovations, the most important probably was the very long neck, the most conspicuous feature of the sauropod bauplan. Compared to other herbivores, the long neck allowed more efficient food uptake than in other large herbivores by covering a much larger feeding envelope and making food accessible that was out of the reach of other herbivores. Sauropods thus must have been able to take up more energy from their environment than other herbivores. The long neck, in turn, could only evolve because of the small head and the extensive pneumatization of the sauropod axial skeleton, lightening the neck. The small head was possible because food was ingested without mastication. Both mastication and a gastric mill would have limited food uptake rate. Scaling relationships between gastrointestinal tract size and basal metabolic rate (BMR) suggest that sauropods compensated for the lack of particle reduction with long retention times, even at high uptake rates. The extensive pneumatization of the axial skeleton resulted from the evolution of an avian‐style respiratory system, presumably at the base of Saurischia. An avian‐style respiratory system would also have lowered the cost of breathing, reduced specific gravity, and may have been important in removing excess body heat. Another crucial innovation inherited from basal dinosaurs was a high BMR. This is required for fueling the high growth rate necessary for a multi‐tonne animal to survive to reproductive maturity. The retention of the plesiomorphic oviparous mode of reproduction appears to have been critical as well, allowing much faster population recovery than in megaherbivore mammals. Sauropods produced numerous but small offspring each season while land mammals show a negative correlation of reproductive output to body size. This permitted lower population densities in sauropods than in megaherbivore mammals but larger individuals. Our work on sauropod dinosaurs thus informs us about evolutionary limits to body size in other groups of herbivorous terrestrial tetrapods. Ectothermic reptiles are strongly limited by their low BMR, remaining small. Mammals are limited by their extensive mastication and their vivipary, while ornithsichian dinosaurs were only limited by their extensive mastication, having greater average body sizes than mammals. 相似文献
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Hanns-Christian Gunga Karl Kirsch Lothar R?cker Claus Behn Eberhard Koralewski Eliseo Hibert Davila Manuel Ivan Estrada Bernd Johannes Peter Wittels Wolfgang Jelkmann 《European journal of applied physiology and occupational physiology》1999,79(6):484-490
It was the aim of this study to investigate the time course of changes in the serum concentrations of vascular endothelial growth factor (VEGF) during a regular survival training programme combined with food and fluid deprivation and during a high altitude marathon run. We studied soldiers of the Austrian Special Forces performing survival training at sea-level and marathon runners of the Posta Atletica who crossed the border between Chile and Argentina at altitudes up to 4722 m. Baseline data collected before the 1-week of survival training showed that the soldiers had normal VEGF [n = 8, 246.7 (SD 118.5) pg.ml(-1)] serum concentrations which remained unchanged during the course of the study. Before the high altitude marathon the subjects showed normal VEGF serum concentrations [178 (SD 84.5) pg.ml(-1)]. After the run VEGF concentrations were found to be significantly decreased [41.0 (SD 41.6) pg ml(-1), P < 0.01]. It was concluded that prolonged physical stress during normobaric-normoxia did not alter the VEGF concentrations whereas during severe hypobaric-hypoxia decreased VEGF serum concentrations were measured, at least temporarily, after prolonged physical exercise which might have been due to changes in production, release, removal and/or binding of circulating VEGF. 相似文献
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H. -Chr. Gunga K. Kirsch F. Baartz H. -J. Steiner P. Wittels L. R?cker 《European journal of applied physiology and occupational physiology》1995,70(1):1-5
To quantify fluid distribution at a moderate altitude (2,315 m) 29 male subjects were studied with respect to tissue thickness changes [front (forehead), sternum, tibia], changes of total body water, changes of plasma volume, total protein concentrations (TPC), colloid osmotic pressure (COP), and electrolytes. Tissue thickness at the forehead showed a significant increase from 4.14 mm to 4.41 mm 48 h after ascent to the Rudolfshuette (2,315 m) (P < 0.05). At 96 h after ascent the tissue thickness at the tibia was decreased to 1.33 mm compared to the control value of 1.59 mm (P < 0.01). Body mass increased from 75.5 kg (control) to 76.2 kg on the last day (P < 0.05) and body water from 44.21 to 45.01 during the week (P < 0.01). The accumulation fluid in the upper part of the body was paralleled by a decrease in TPC and COP. At 48 h after the ascent COP dropped from 29.5 mmHg to 27.5 mmHg (P < 0.01). After 96 h at moderate altitude COP was still significantly decreased compared to the control level. At 1.5 h after the return from the Rudolfshuette in Saalfelden (744m) COP was back to the control values. The TPC also showed an initial drop from 7.75 g · dl–1 to 7.48 g · dl–1 after 48 h at altitude and remained below the control value during the whole week (P < 0.01). It seems from our study that even with exposure to moderate altitude measurable fluid shifts to the upper part of the body occurred which were detected by our ultrasound method. 相似文献
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Hanns-Christian Gunga Mariann Sandsund Randi E. Reinertsen Frank Sattler Jochim Koch 《Journal of thermal biology》2008
Heat stroke remains a very dangerous, potentially lethal illness in humans. The Physiological Strain Index (PSI), originally based on heart rate and rectal temperature recordings in humans, describes heat strain in quantitative terms. The objective of our study was to establish whether the rectal temperature recordings serving to determine the PSI could be replaced by a non-invasive skin temperature sensor combined with a heat flux sensor (Double Sensor) attached to the inside of a helmet. We assumed (i) that the difference between the recordings by the device under test and the rectal temperature should be less than ±1.0 °C for ±2 S.D. at 10, 25, and 40 °C ambient temperature, and (ii) that the temperature predictions based on the Double Sensor temperature should differ by less than 1 PSI score from the calculations based on recordings of the rectal temperature. Twenty male subjects participated in the study. Rectal, nasopharyngeal, and skin temperatures, heat flux, and cardiovascular data were collected continuously during different experimental setups at ambient temperatures of 10, 25, and 40 °C. Depending on the protocols, the exercise intensities varied from 25% to 55% of the individual VO2max. A comparison of the recordings obtained from the device under test with those of the rectal temperature revealed that (i) the recordings of the Double Sensor differed by −0.16 to 0.1 °C from the mean rectal temperature, (ii) the concordance correlation coefficients (CCC) during all work and rest periods rose with rising ambient temperatures (all work periods: 10 °C: 0.49; 25 °C: 0.69; 40 °C: 0.75; all rest periods: 10 °C: 0.39; 25 °C: 0.81; 40 °C: 0.74), and that (iii) the Double Sensor in the helmet showed that during all rest periods and in all ambient conditions, the temperature dropped much more quickly than what was recorded when taking the rectal temperature (p<0.01). When we compared the PSI values based on the rectal temperature recordings to those determined by the Double Sensor, it was found that (i) the PSI based on the Double Sensor recordings differed by −0.27 to 0.17 from the mean PSI established by rectal temperature recordings. Furthermore, the CCC for the PSI rose during all work periods (10 °C: 0.81, 25 °C: 0.93, 40 °C: 0.87) and rest periods (10 °C: 0.68; 25 °C: 0.93; 40 °C: 0.79). In conclusion, under warm/hot environmental conditions the device under test provided a reliable method of assessing the PSI in operational environments to improve physiological situational awareness and safety in action. However, there are some limitations that reduce the device's performance in cold environments; these need to be investigated further. 相似文献
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Mathias Steinach Eberhard Kohlberg Martina Anna Maggioni Stefan Mendt Oliver Opatz Alexander Stahn Hanns-Christian Gunga 《PloS one》2016,11(2)
Purpose
Antarctic residence holds many challenges to human physiology, like increased psycho-social tension and altered circadian rhythm, known to influence sleep. We assessed changes in sleep patterns during 13 months of overwintering at the German Stations Neumayer II and III from 2008 to 2014, with focus on gender, as many previous investigations were inconclusive regarding gender-based differences or had only included men.Materials & Methods
Time in bed, sleep time, sleep efficiency, number of arousals, sleep latency, sleep onset, sleep offset, and physical activity level were determined twice per month during seven overwintering campaigns of n = 54 participants (37 male, 17 female) using actimetry. Data were analyzed using polynomial regression and analysis of covariance for change over time with the covariates gender, inhabited station, overwintering season and influence of physical activity and local sunshine radiation.Results
We found overall longer times in bed (p = 0.004) and sleep time (p = 0.014) for women. The covariate gender had a significant influence on time in bed (p<0.001), sleep time (p<0.001), number of arousals (p = 0.04), sleep latency (p = 0.04), and sleep onset (p<0.001). Women separately (p = 0.02), but not men (p = 0.165), showed a linear increase in number of arousals. Physical activity decreased over overwintering time for men (p = 0.003), but not for women (p = 0.174). The decline in local sunshine radiation led to a 48 minutes longer time in bed (p<0.001), 3.8% lower sleep efficiency (p<0.001), a delay of 32 minutes in sleep onset (p<0.001), a delay of 54 minutes in sleep offset (p<0.001), and 11% less daily energy expenditure (p<0.001), for all participants in reaction to the Antarctic winter’s darkness-phase.Conclusions
Overwinterings at the Stations Neumayer II and III are associated with significant changes in sleep patterns, with dependences from overwintering time and local sunshine radiation. Gender appears to be an influence, as women showed a declining sleep quality, despite that their physical activity remained unchanged, suggesting other causes such as a higher susceptibility to psycho-social stress and changes in environmental circadian rhythm during long-term isolation in Antarctica. 相似文献10.
Valenti G Fraszl W Addabbo F Tamma G Procino G Satta E Cirillo M De Santo NG Drummer C Bellini L Kowoll R Schlemmer M Vogler S Kirsch KA Svelto M Gunga HC 《Biochimica et biophysica acta》2006,1758(8):1111-1116
Here, we report the alterations in renal water handling in healthy volunteers during a 6 h thermoneutral water immersion at 34 to 36 degrees C. We found that water immersion is associated with a reversible increase in total urinary AQP2 excretion. 相似文献