排序方式: 共有3条查询结果,搜索用时 0 毫秒
1
1.
Aamer Saeed Gufran Saddique Pervaiz Ali Channar Fayaz Ali Larik Qamar Abbas Mubashir Hassan Hussain Raza Tanzeela Abdul Fattah Sung-Yum Seo 《Bioorganic & medicinal chemistry》2018,26(12):3707-3715
To seek the new medicinal potential of sulfadiazine drug, the free amino group of sulfadiazine was exploited to obtain acyl/aryl thioureas using simple and straightforward protocol. Acyl/aryl thioureas are well recognized bioactive pharmacophore containing moieties. A new series (4a–4j) of sulfadiazine derived acyl/aryl thioureas was synthesized and characterized through spectroscopic and elemental analysis. The synthesized derivatives 4a–4j were subjected to calf intestinal alkaline phosphatase (CIAP) activity. The derivative 4a–4j showed better inhibition potential compared to standard monopotassium phosphate (MKP). The compound 4c exhibited higher potential in the series with IC50 0.251?±?0.012?µM (standard KH2PO4 4.317?±?0.201?µM). Lineweaver-Burk plots revealed that most potent derivative 4c inhibition CIAP via mixed type pathway. Pharmacological investigations showed that synthesized compounds 4a–4j obey Lipinsk’s rule. ADMET parameters evaluation predicted that these molecule show significant lead like properties with minimum possible toxicity and can serve as templates in drug designing. The synthetic compounds show none mutagenic and irritant behavior. Molecular docking analysis showed that compound 4c interacts with Asp273, His317 and Arg166 amino acid residues. 相似文献
2.
Zulfiqar Ali Raza Zafar M. Khalid Mohammad Saleem Khan Ibrahim M. Banat Asma Rehman Abdul Naeem Muhammad Tahir Saddique 《Biotechnology letters》2010,32(6):811-816
Tensioactive properties of rhamnolipids produced by a Pseudomonas aeruginosa strain were investigated in the presence or absence of Sr2+ or Pb2+. Surface and interfacial properties, and aggregate forming properties and morphologies were studied by various techniques
including scanning electron microscopy. When the pH of a rhamnolipid aqueous solution (40 mg/l) was increased from 5 to 8,
irregular vesicles gradually took the shape of oligo-vesicles, then regular vesicles and finally smaller spherical vesicles.
Addition of metal ions controlled the aggregates’ morphology and stability, and influenced the surface and interfacial behavior
of rhamnolipid solutions. 相似文献
3.
Ahmad Gufran Khan Amir Khan Abrar A. Ali Asgar Mohhamad Heba I. 《Antonie van Leeuwenhoek》2021,114(7):885-912
Antonie van Leeuwenhoek - Plant parasitic nematodes (Root-knot nematodes, Meloidogyne spp.) are rounded worms, microscopic, and cause many agricultural economic losses. Their attacks have a direct... 相似文献
1