排序方式: 共有7条查询结果,搜索用时 31 毫秒
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Colares Tamiris Gago de Figueiredo Camila Saggioro de Oliveira Jesus Souza Lucienne dos Santos Aline Araujo Giestal-de-Araujo Elizabeth 《Neurochemical research》2021,46(7):1701-1716
Neurochemical Research - Interleukin-2 (IL-2) is a classical pro-inflammatory cytokine known to display neuroprotective roles in the central nervous system including the retina. In the present... 相似文献
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Rafael Perígolo-Vicente Karen Ritt Mariana Rodrigues Pereira Patrícia Maria Mendonça Torres Roberto Paes-de-Carvalho Elizabeth Giestal-de-Araujo 《Biochemical and biophysical research communications》2013,430(2):512-518
IL-6 is a pleiotropic cytokine classically denominated pro-inflammatory. It has been already demonstrated that IL-6 can increase the survival of retinal ganglion cells (RGC) in culture. In this work, we show that the trophic effect of IL-6 is mediated by adenosine receptor (A1R) activation. The neutralization of extracellular BDNF abolished the IL-6 effect and the treatment with IL-6 and CHA (an agonist of A1R) modulated BDNF expression as well as pCREB and pTrkB levels. 相似文献
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Rafael Perígolo-Vicente Karen Ritt Cassiano Felippe Gonçalves-de-Albuquerque Hugo Caire Castro-Faria-Neto Roberto Paes-de-Carvalho Elizabeth Giestal-de-Araujo 《Biochemical and biophysical research communications》2014
Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to be able to increase the survival and regeneration of retinal ganglion cells (RGC) in mixed culture as well as in vivo. In this work we show that the trophic effect of IL-6 is mediated by adenosine receptor (A2aR) activation and also by the presence of extracellular BDNF. We also show that there is a complex cross-talk between IL-6, BDNF, the Adenosine A1 and A2a receptors that results in neuroprotection of retinal ganglion cells. 相似文献
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Mázala-de-Oliveira Thalita de Figueiredo Camila Saggioro de Rezende Corrêa Gustavo da Silva Mayra Santos Miranda Renan Lyra de Azevedo Mariana Almeida Cossenza Marcelo dos Santos Aline Araujo Giestal-de-Araujo Elizabeth 《Neurochemical research》2022,47(3):723-738
Neurochemical Research - Ouabain is a classic Na+K+ATPase ligand and it has been described to have neuroprotective effects on neurons and glial cells at nanomolar concentrations. In the present... 相似文献
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