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1.
With the use of 32P-labeled phosphate and 42K2CO3 the effect of diphenyl on permeability and uptake properties of the cytoplasmic membrane in wild type and diphenyl-tolerant mutant conidia of Fusarium solani f. cucurbitae was studied. No general damage to the membrane with unspecific leakage of cell constituents was demonstrated under conditions in which diphenyl prevents germination of wild type conidia. The fresh conidia do not require exogenous supply of energy for the uptake of phosphate or of potassium. In the wild type the entry of 32P is inhibited but that of 42K strikingly stimulated by diphenyl. Independently of the tolerant mutant gene present, the mutant conidia are significantly less sensitive to the phosphate uptake inhibition and not affected at all by diphenyl with respect to the uptake of potassium. The latter difference from the wild type seems to indicate genetic control of some property of the potassium transport system in this fungus. 相似文献
2.
M. Nardino F. Pernice F. Rossi T. Georgiadis O. Facini A. Motisi A. Drago 《Photosynthetica》2013,51(1):63-74
At present, research activities on the role of orchard systems in sequestering atmospheric CO2 remain scarce. This paper aimed to contribute to assessing the carbon balance of a Mediterranean olive (Olea europea) orchard. The net ecosystem exchange, the ecosystem respiration and the gross primary production were computed for two consecutive years through eddy covariance, and the different biomass accumulation terms were also inferred in the same period through an inventorial method. The net carbon exchange ranged from 13.45 t(C) ha?1 year?1 to 11.60 t(C) ha?1 year?1. Very similar values [12.2 and 11.5 t(C) ha?1 year?1] were found with the direct carbon accumulation inventory. The intensive farming management (irrigation included) and the young age of the plants (12–16 years old), still in an active growing phase, led the olive plantation to be a higher carbon sink with respect to other evergreen orchards reported in the literature. 相似文献
3.
BackgroundAntenatal depression affects up to 19% of pregnant women. Some of these women are also in need of antidepressant treatment. Nevertheless, the impact of maternal antidepressant treatment and prenatal depression on the course of pregnancy, foetal development and delivery outcomes is not fully understood.MethodsWe analysed data from 24 818 women who gave birth at Kuopio University Hospital between 2002–2012. Logistic regression analysis was used to estimate associations between the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and the progression of pregnancy, development of the foetus and delivery outcomes.ResultsAltogether, 369 (1.5%) women used SSRIs. A regression model adjusted for age, overweight, nulliparity, prior termination, miscarriages, smoking, maternal alcohol consumption, chronic illness and polyhydramnion showed that pregnant women exposed to SSRI medication had significantly lower Apgar scores at 1 minute (p < 0.0001) and 5 minutes (p < 0.0001) and more admissions to the neonatal intensive care unit (p < 0.0001) than unexposed pregnant women. In addition, exposed newborns had longer umbilical cords (p < 0.0001) than non-exposed newborns.ConclusionIn addition to the previously known associates with maternal SSRI exposure, such as lowered Apgar scores, SSRI exposure appeared to be associated with increased umbilical cord length. The observation related to increased umbilical cord length may be explained by an SSRI-induced increase in the movements of the developing foetus. 相似文献
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Comstock KE Georgiadis N Pecon-Slattery J Roca AL Ostrander EA O'Brien SJ Wasser SK 《Molecular ecology》2002,11(12):2489-2498
The highly threatened African elephants have recently been subdivided into two species, Loxodonta africana (savannah or bush elephant) and L. cyclotis (forest elephant) based on morphological and molecular studies. A molecular genetic assessment of 16 microsatellite loci across 20 populations (189 individuals) affirms species level genetic differentiation and provides robust genotypic assessment of species affiliation. Savannah elephant populations show modest levels of phylogeographic subdivision based on composite microsatellite genotype, an indication of recent population isolation and restricted gene flow between locales. The savannah elephants show significantly lower genetic diversity than forest elephants, probably reflecting a founder effect in the recent history of the savannah species. 相似文献
6.
LaTeca S. Glass Aditi Bapat Mark R. Kelley Millie M. Georgiadis Eric C. Long 《Bioorganic & medicinal chemistry letters》2010,20(5):1685-1688
High-throughput fluorescent intercalator displacement (HT–FID) was adapted to the semi-automated screening of a commercial compound library containing 60,000 molecules resulting in the discovery of cytotoxic DNA-targeted agents. Although commercial libraries are routinely screened in drug discovery efforts, the DNA binding potential of the compounds they contain has largely been overlooked. HT–FID led to the rapid identification of a number of compounds for which DNA binding properties were validated through demonstration of concentration-dependent DNA binding and increased thermal melting of A/T- or G/C-rich DNA sequences. Selected compounds were assayed further for cell proliferation inhibition in glioblastoma cells. Seven distinct compounds emerged from this screening procedure that represent structures unknown previously to be capable of targeting DNA leading to cell death. These agents may represent structures worthy of further modification to optimally explore their potential as cytotoxic anti-cancer agents. In addition, the general screening strategy described may find broader impact toward the rapid discovery of DNA targeted agents with biological activity. 相似文献
7.
Alexandros A. Karamanlidis Elena Drosopoulou Miguel de Gabriel Hernando Lazaros Georgiadis Lambros Krambokoukis Stavri Pllaha Andreas Zedrosser Zacharias Scouras 《European Journal of Wildlife Research》2010,56(5):693-702
One difficulty in the conservation of endangered wildlife is the lack of reliable information on its status. This lack of
knowledge can often be attributed to financial and logistic constraints as well as the lack of trained personnel to collect
data. We test a simple method to study bears in the southern Balkans by inspecting power poles, which are used by bears for
marking and rubbing purposes. We created a network of barbed-wire fitted poles for the collection of hair samples, evenly
distributed throughout six study areas. During 87 sampling sessions in the main study area, we collected 191 samples and identified
six microsatellite loci that were variable enough for individual bear identification. The most and best-quality hair samples
were collected during the mating period, and DNA was most successfully extracted from samples remaining <4 weeks in the field.
In the six study areas, we identified 47 bears. An advantage of using power poles for hair sampling is their availability
and accessibility; no bait is required, and the network can be easily set up. A drawback may be an unequal capture probability
of sex and age classes of bears. Despite this limitation, using power poles proved to be a simple and cheap method for the
noninvasive genetic study of bears that did not require any prior knowledge on habitat use and activity patterns. The method
is suitable for large-scale surveys to estimate distribution and relative densities of bears and could also be applied for
studying other species. 相似文献
8.
Bursavich MG Gilbert AM Lombardi S Georgiadis KE Reifenberg E Flannery CR Morris EA 《Bioorganic & medicinal chemistry letters》2007,17(20):5630-5633
5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. Selected compounds 23, 33-35 show sub-micromolar ADAMTS-5 potency and strong SAR trends with selectivity over the related metalloproteases ADAMTS-4 (Aggrecanase-1), MMP12, and MMP13. This series of compounds represents progress toward a selective ADAMTS-5 inhibitor as a disease modifying osteoarthritis drug. 相似文献
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