Relationship between Neutrophins and Gut Microbiome in Various Metabolic Types of Obesity

Journal of Evolutionary Biochemistry and Physiology - Obesity is associated with a gut microbiome imbalance and the risk of neurological complications. However, the risk of complications is...     

Louse Flies (Diptera,Hippoboscidae) in Bird Nests in Voronezh Province

Entomological Review - Eight species of louse flies were recorded on 22 bird species as the result of research carried out in 2008–2018 in Voronezh Province of Russia. Five species are...     

Glycan recognition by human blood mononuclear cells with an emphasis on dendritic cells

Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. To this end, we explored recognition of DCs lectins by glycans. For selection of the glycan “vector”, a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14^low/-CD16⁺CD83⁺ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes. It was found that: 1) the glycan-binding profiles of this CD14^low/-CD16⁺CD83⁺ subpopulation were similar but not identical to DCs of monocyte origin (moDCs); 2) the highest percentage of probe-positive cells in this CD14 ^low/-CD16⁺CD83⁺ subpopulation was observed for GalNAcα1-2Galβ (A_di), (Neu5Acα)₃ and three mannose-reach glycans; 3) subpopulation of CD14^low/-CD16⁺ cells preferentially bound 4’-O-Su-LacdiNAc. Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 ^low/-CD16⁺CD83⁺ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2. In contrast, DC-SIGN is not apparently involved, even in case of mannose-rich glycans. Taking into consideration potential in vivo competition between glycan “vectors” and glycans within glycocalyx, attempting to target vaccine to DCs glycan-binding receptors should focus on A_di and (Neu5Acα)₃ as the most promising vectors.     

Alkylresorcinols: New Potential Bioregulators in the Superorganism System (Human–Microbiota)

Biology Bulletin - Based on the results of qualitative and quantitative analysis of alkylresorcinol pools in the intestine and in the blood, as well as their correlations with the level of...     

Characteristics of DNA replication of the chromosomes of the bone marrow cells in patients with acute leukemia]

A study of the late DNA replication pattern in chromosomes of human acute leucaemia cells revealed a significant diffrence from control. Chromosomes, 2,3 and 4-5 of the acute leucaemia cells finish their DNA replication earlier, and chromosomes 1, 13-15 and 16 later, compared to the control chromosomes. The difference in the pattern of DNA replication between analogous chromosomes of acute leucaemia and donor cells was associated with the discovery of large late-replicating chromatin blocks in the pericentromeric regions of leucaemia cell chromosomes. Some relationship is suggested between the pattern of pericentromeric heterochromatin DNA replication and cell differentiation.