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排序方式: 共有146条查询结果,搜索用时 197 毫秒
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Elevation of Taurine in Hippocampal Extracellular Fluid and Cerebrospinal Fluid of Acutely Hypoosmotic Rats: Contribution by Influx from Blood? 总被引:3,自引:2,他引:1
Anders Lehmann Christian Carlström Erlend A. Nagelhus† Ole Petter Ottersen† 《Journal of neurochemistry》1991,56(2):690-697
Previous work has demonstrated that there is a selective increase in extracellular taurine in the brain during acute water intoxication. One aim of the present study was to investigate whether plasma taurine contributes to this increase. To this end, the concentrations of taurine, other amino acids, and ethanolamine (EA) were measured in plasma and CSF of urethane-anesthetized rats injected with 150 ml/kg body weight of distilled water. Blood pressure, blood gases, and pH, as well as plasma and CSF osmolality, were also measured. The CSF level of albumin was quantitated to study the function of the blood-CSF barrier. In separate experiments, hippocampal microdialysis was performed to determine the effects of acute plasma hypoosmolality on extracellular amino acids. Finally, the effect of water injection on hippocampal specific gravity and tissue amino acids was assessed. Blood gases and pH were essentially unchanged after water administration. Mean arterial blood pressure increased to peak levels approximately 50 mm Hg above control. Plasma osmolality decreased rapidly, whereas the depression of CSF osmolality was slower and less pronounced. The average volume of the hippocampus increased by 8%. Water injection was accompanied by a 25-fold elevation of taurine in plasma, whereas phosphoethanolamine (PEA) and EA increased moderately. A small fraction of the increase in plasma taurine might derive from blood cells because dilution of blood in vitro led to doubled plasma levels of the amino acid. Taurine, PEA, and EA increased consistently in CSF and hippocampal microdialysates. Plasma hypoosmolality transiently opened the blood-CSF barrier is reflected by augmented CSF concentrations of albumin.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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The structure of the polysaccharide antigen produced by Eubacterium saburreum, strain L 32, has been investigated. The principal methods used were methylation analysis, graded hydrolysis with acid, and n.m.r. spectroscopy. The polysaccharide, which contains the unusual sugar 3,6-dideoxy-D-arabino-hexose (tyvelose, Tyv), is composed of trisaccharide repeating-units having the following structure: 相似文献
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G A van der Hofstad A Buitenhek P J van den Elsen H O Voorma L Bosch 《European journal of biochemistry》1978,89(1):221-228
The binding of labeled initiation factor IF-1 to ribosomal particles has been studied in relation to the mode of action of this factor in the dissociation of 70-S ribosomes. It is demonstrated that IF-1 interacts specifically with active 70-S tight couples and free 30-S subunits. The binding of IF-1 to both 70-S and 30-S particles is not influenced by the Mg2+ concentration and the affinity of the factor for both particles is about the same. The interaction of IF-1 with these particles is highest at low Tris-HCl concentrations. Under these conditions IF-1 shows a slight dissociating activity. Using 3H-labeled IF-1 and 14C-labeled IF-3 the formation of a 30-S-subunit.IF-1 . IF-3 complex from 70-S ribosomes is demonstrated. Our studies show that IF-3 enhances the binding of IF-1 to the 30-S subunit. In contrast to IF-1, which binds about equally well to 70-S and 30-S particles in the absence of IF-3, 14C-labeled IF-3 binds predominantly to the 30-S subunit. This finding confirms the view that IF-3 acts as an anti-association factor. On the other hand, IF-1 enhances the supply of 30-S subunits in the presence of IF-3 by acting on the 30-S moiety of the 70-S ribosome. 相似文献
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The polysaccharide antigen produced by Eubacterium saburreum, strain L 49, is composed of D-glycero-D-galacto-heptose and a new sugar, tentatively identified as 6-deoxy-D-altro-heptose. It contains chains of alternating (1 leads to 3)- and (1 leads to 6)- linked beta-D-glycero-D-galacto-heptopyranosyl residues, the latter being substituted with 6-deoxy-alpha-heptofuranosyl groups at O-3. The polysaccharide further contains 0-acetyl groups, linked to O-7 of part of the heptosyl residues and to O-2 of part of the 6-deoxyheptosyl groups. 相似文献
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Shwartzman's reaction was elicited in four Chinchilla rabbits. Two of the animals were tranquillized with fentanyl-fluanisone (Hypnorm: Janssen Pharmaceuticals). There was a reduced response in the tranquillized rabbits while the untranquillized animals developed the typical dose-responsive skin reaction. Fentanyl-fluanisone tranquillization may interfere with the development of the Shwartzman reaction in Chinchilla rabbits. 相似文献
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Diana E. Bowler Mikkel A. J. Kvasnes Hans C. Pedersen Brett K. Sandercock Erlend B. Nilsen 《Proceedings. Biological sciences / The Royal Society》2020,287(1941)
According to classic theory, species'' population dynamics and distributions are less influenced by species interactions under harsh climatic conditions compared to under more benign climatic conditions. In alpine and boreal ecosystems in Fennoscandia, the cyclic dynamics of rodents strongly affect many other species, including ground-nesting birds such as ptarmigan. According to the ‘alternative prey hypothesis’ (APH), the densities of ground-nesting birds and rodents are positively associated due to predator–prey dynamics and prey-switching. However, it remains unclear how the strength of these predator-mediated interactions change along a climatic harshness gradient in comparison with the effects of climatic variation. We built a hierarchical Bayesian model to estimate the sensitivity of ptarmigan populations to interannual variation in climate and rodent occurrence across Norway during 2007–2017. Ptarmigan abundance was positively linked with rodent occurrence, consistent with the APH. Moreover, we found that the link between ptarmigan abundance and rodent dynamics was strongest in colder regions. Our study highlights how species interactions play an important role in population dynamics of species at high latitudes and suggests that they can become even more important in the most climatically harsh regions. 相似文献
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Mikkel A. J. Kvasnes Torstein Storaas Hans Chr. Pedersen Svein Bjørk Erlend B. Nilsen 《Ecological Research》2010,25(2):367-374
Different species in a given site or population of a given species in different sites may fluctuate in synchrony if they are
affected similarly by factors such as spatially autocorrelated climate, predation, or by dispersal between populations of
one species. We used county wise time series of hunting bag records of four Norwegian tetraonid species covering 24 years
to examine patterns of interspecific and intraspecific synchrony. We estimated synchrony at three spatial scales; national,
regional (consisting of counties with similar climate), and county level. Ecologically related species with overlapping distributions
exhibited strong synchrony across Norway, but there was much variation between the different regions and counties. Regions
with a long coastline to both the North Sea and the Norwegian Ocean exhibited an overall stronger synchrony than those consisting
of more continental areas. Intraspecific synchrony was generally low across all counties, but stronger synchrony between counties
within regions defined by climatic conditions. Synchrony was negatively related to distance between populations in three of
four species. Only the synchrony in willow ptarmigan showed a clear negative relationship with distance, while the other species
had both strong positive and negative correlations at short distances. Strong interspecific synchrony between some species
pairs within regions and weak intraspecific synchrony across counties within regions suggest a stronger synchronizing effect
from environmental factors such as weather or predation and less effect from dispersal. Our results suggest that the complete
tetraonid community is structured by environmental factors affecting the different species similarly and causes widespread
interspecific synchrony. Local factors affecting the population dynamics nevertheless frequently forces neighbouring populations
out of phase. 相似文献