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Calorimetric properties of mixtures of ganglioside GM1 and dipalmitoylphosphatidylcholine 总被引:2,自引:0,他引:2
L O Sillerud D E Schafer R K Yu W H Konigsberg 《The Journal of biological chemistry》1979,254(21):10876-10880
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Restriction sites containing CpG show a higher frequency of polymorphism in human DNA 总被引:122,自引:0,他引:122
Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes, Msp I and Taq I, whose recognition sequences have in common the dimer sequence CpG. The cytosines in the CpG sequence are known to be frequently methylated in mammals, and the occurrence of significant variation in Msp I and Taq I sites supports the view that methylated cytosine residues are hotspots for mutation in mammalian DNA. 相似文献
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Klaus Schmidt und Eberhard Hantge 《Journal of Ornithology》1954,95(1-2):130-173
Ohne ZusammenfassungMrs. Margaret M. Nice gewidmet zum 70. Geburtstag am 6. Dezember 1953In verkürzter Form vorgetragen vonK. Schmidt auf der 67. Tagung der D. O.-G. am 16. August 1953 in Köln. — 291. Ringfundmitteilung der Vogelwarte Radolfzell. 相似文献
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Eberhard Gischler 《Facies》2010,56(2):173-177
Shallow fore-reef areas worldwide are usually characterized by spurs and grooves. A comparison of examples from the three
world oceans suggests that Indo-Pacific spurs and grooves are shaped predominantly by erosion, whereas western Atlantic spur
and groove systems are largely a product of constructive processes. I propose that this difference is caused by regional differences
in Holocene sea-level change, which controlled exposure to waves and currents, and reef-accretion rates. The transgressive–regressive
sea-level curve in the Indo-Pacific realm, i.e., the Mid-to-Late Holocene sea-level fall in these areas has maintained high-energy
conditions in the shallow fore reef. Higher exposure to waves and currents favors erosion and leads to a dominance of crustose
coralline algae that have relatively slow growth rates. In the western Atlantic, the transgressive Holocene sea level has
caused Mid-to-Late Holocene deepening and has maintained accommodation space for reef accretion. Fast-growing acroporid corals
thrive under lower exposure and are more common than coralline algae. The fossil record of the spur and groove system is rather
poor, which is probably a consequence of the need of excellent, three-dimensional outcrops for identification. 相似文献
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M L Eberhard M N Njenga A J DaSilva D Owino E K Nace K Y Won J M Mwenda 《The Journal of parasitology》2001,87(6):1394-1397
From March 1999 through August 2000, 511 stool samples collected from 11 different primate species in 10 geographically distinct locations in Kenya, East Africa, were screened for the presence of Cyclospora spp. oocysts. Positive samples (43/102, 42%) were identified in vervet monkeys (Cercopithecus aethiops) in 4 of 4 locations; 19/206 (9%) in yellow and olive baboons (Papio cynocephalus, P. anubis, respectively) in 5 of 5 locations; and 19/76 (25%) in black and white colobus monkeys (Colobus angolensis, C. guereza, respectively) from 2 of 3 locations. DNA sequences obtained from 18 S rRNA coding regions from respective subsets of these positive samples were typed as Cyclospora cercopitheci (samples from Cercopithecus aethiops). Cyclospora papionis (samples from Papio cynocephalus and P. anubis), and Cyclospora colobi (samples from Colobus angolensis and C. guereza). Cyclospora oocysts were not detected in samples collected from patas, highland sykes, lowland sykes, blue sykes, DeBrazza, or red-tailed monkeys. A coded map showing the geographic location of the collected samples is given. Stool samples from 1 troop of vervet monkeys were collected over a 12-mo period. Positive samples ranged between 21 and 63%. These results suggest that there is no strongly marked seasonality evident in Cyclospora infection in monkeys as has been noted in human infection. This is further confirmed by the recovery of positive samples collected from vervet monkeys, baboons, and colobus monkeys at all times of the year during this survey. This absence of seasonality in infection is especially notable because of the extreme weather patterns typical of Kenya, where marked rainy and dry seasons occur. A second noteworthy observation is that the striking host specificity of the Cyclospora species initially described was confirmed in this survey. Baboons were only infected with C. papionis, vervet monkeys with C. cercopitheci, and colobus monkeys with C. colobi, despite geographic overlaps of both the monkey and parasite species and wide geographic distribution of each parasite and monkey host. 相似文献