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排序方式: 共有132条查询结果,搜索用时 62 毫秒
1.
Donal F. Early 《BMJ (Clinical research ed.)》1973,3(5878):491-494
A housing association for the rehabilitation of adults suffering from psychiatric illness now has six council houses, a former private hotel, and two large houses—providing a total of 100 places. The cost of full board and lodging is about £6·00 a week; the association shows a small profit; and virtually all the residents are in open or sheltered work. 相似文献
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V S Hinshaw W J Bean R G Webster J E Rehg P Fiorelli G Early J R Geraci D J St Aubin 《Journal of virology》1984,51(3):863-865
Influenza A virus isolates of the H4N5 subtype (which has previously been detected only in birds) were recovered from harbor seals dying of viral pneumonia on the New England coast from June 1982 through March 1983. When these isolates were compared with other mammalian and avian viruses in serological assays and RNA-RNA competitive hybridization, it was found that the seal viruses were most closely related antigenically and genetically to recent avian virus strains and were readily distinguishable from mammalian viruses, including H7N7 isolates recovered from seals in 1980. Unlike any previous isolates from mammals, these recent seal viruses replicate in the intestinal tracts of ducks, a characteristic of avian viruses. The association of avian viruses with influenza outbreaks in seals suggests that transmission of avian viruses to seals is occurring in nature. Potentially, this may be an example of the adaptation of avian viruses to mammals, which would represent an intermediate step in the evolution of new mammalian strains. 相似文献
4.
Release of soluble reactive phosphorus (SRP) from dissolved organic phosphorus (DOP), concentrated by reverse osmosis of water
samples from Lough Neagh Northern Ireland, was measured in the presence of enzymes and cultures of lake water bacteria in
a basal liquid medium adjusted to the pH of lake water (7.6). No hydrolysis of unfractionated DOP was observed in the presence
of alkaline phosphatase but a combination of alkaline phosphatase and phosphodiesterase mineralized 14% of DOP in a 30 day
incubation period at 15 °C. A similar amount of mineralization was attained by phytase. Phytase induced the same degree of
mineralization in a range of DOP fractions varying from MW > 100 000 to c. 500. A mixed culture of lake water bacteria mineralized
12% of unfractionated DOP. Single cultures of lake water bacteria displayed low mineralizing activity (mean of 49 cultures
= 5% DOP hydrolysed). Results indicate that DOP from Lough Neagh in the above molecular weight range is predominantly recalcitrant
to bacterial mineralization under natural lake conditions. 相似文献
5.
The effect of lincocin (a plastid protein synthesis inhibitor) treatment on the greening process of bean (Phaseolus vulgaris L.) leaves have been studied. In comparison with control leaves treated ones had a decreased rate of chloroplast development. They had a marked chlorophyll deficiency and a decreased chlorophyll a/b ratio. Some long and short wavelength forms of chlorophyll a were lacking as evidenced from the absorption spectra at 25°C and the fluorescence spectra at 77°K. The –14CO2 fixation was inhibited by 80–90% in treated leaves. The fluorescence induced by the measuring light was greater in the treated leaves than in the control ones, and the kinetics of the decline of the relative fluorescence intensity were also different. Electron microscopic studies showed macrogranum-like structures and incomplete membrane vesicles in the treated plastids. After longer treatment a destruction of membranes was observed. The results indicate some structural and functional membrane deficiencies and instability of the membranes. 相似文献
6.
Margaret Burchinal Carollee Howes Robert Pianta Donna Bryant Diane Early Richard Clifford 《应用发育科学》2013,17(3):140-153
Publicly funded prekindergartens are programs that most states use to promote school readiness, especially of 4-year-old children at risk for academic problems due to poverty. Despite large public expenditures, these programs have not been widely evaluated. We examined 240 randomly selected pre-kindergarten programs in six states with mature programs that serve large numbers of children, and evaluated specific aspects of classroom quality and children's academic achievement in both the pre-kindergarten and kindergarten year for over 700 children. Results showed that, on average, pre-kindergarten teachers were moderately responsive and sensitive, but were less successful in engaging children in learning specific skills. Both sensitive and stimulating interactions with the teacher and the instructional quality aspects of the pre-kindergarten classroom predicted the acquisition of language, pre-academic, and social skills through the end of the kindergarten year. 相似文献
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Joseph B. Greer Bryan P. Early Kenneth R. Durbin Steven M. Patrie Paul M. Thomas Neil L. Kelleher Richard D. LeDuc Ryan T. Fellers 《Proteomics》2022,22(11-12):2100209
The effectiveness of any proteomics database search depends on the theoretical candidate information contained in the protein database. Unfortunately, candidate entries from protein databases such as UniProt rarely contain all the post-translational modifications (PTMs), disulfide bonds, or endogenous cleavages of interest to researchers. These omissions can limit discovery of novel and biologically important proteoforms. Conversely, searching for a specific proteoform becomes a computationally difficult task for heavily modified proteins. Both situations require updates to the database through user-annotated entries. Unfortunately, manually creating properly formatted UniProt Extensible Markup Language (XML) files is tedious and prone to errors. ProSight Annotator solves these issues by providing a graphical interface for adding user-defined features to UniProt-formatted XML files for better informed proteoform searches. It can be downloaded from http://prosightannotator.northwestern.edu . 相似文献
9.
Branca M Migliore G Giuliani M Morosini PL Mudu P Cappiello G Garbuglia AR Ippolito G Rezza G;Early Diagnosis of Neoplasia in AIDS Cooperative Study Group 《Acta cytologica》2000,44(6):1000-1004
OBJECTIVE: To investigate the relationship between specific cytopathologic changes, koilocyte counts and human papillomavirus (HPV) types in HIV-positive and -negative women. STUDY DESIGN: A cohort of 459 women (266 HIV+ and 193 HIV-), were examined in a multicentric study (Early Diagnosis of Neoplasia in AIDS) involving 14 gynecologic centers. Altogether, 97 women had cervical smears consistent with squamous intraepithelial lesions (SIL). Koilocytes were found in 60/97 SIL slides, subjected to quantitative counting in 30 predetermined fields. HPV genotype was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: SIL lesions were four times more frequent (29%) in HIV-positive women than in HIV-negative women (10%) (odds ratio = 3.80). HPV DNA was equally frequent in both groups. There was a strong association between the number of koilocytes and HIV serostatus in both high grade and low grade SIL diagnoses. The presence of eight or more koilocytes had a specificity of 93% and sensitivity of 76% toward the diagnosis of HIV-positive status. No HIV-negative woman had a count > 8 koilocytes. No association was shown between koilocyte count and HPV genotype. CONCLUSION: An elevated number of koilocytes could suggest the possibility of HIV infection. Pap smear examination might give the first clue to HIV positivity in otherwise-unsuspected cases. 相似文献
10.
Tamagnan GD Brenner E Alagille D Staley JK Haile C Koren A Early M Baldwin RM Tarazi FI Baldessarini RJ Jarkas N Goodman MM Seibyl JP 《Bioorganic & medicinal chemistry letters》2007,17(2):533-537
A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPECT imaging in baboons. The in vivo specificity, selectivity, and kinetics of [123I]INER make it a promising agent for imaging NET in vivo by noninvasive SPECT imaging. 相似文献