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S O Bachurin S O Sablin G V Grishina E L Ga?darova D G Dubova 《Bioorganicheskaia khimiia》1989,15(5):620-626
Kinetics of monoamine oxidase (MAO) catalyzed dehydrogenation of neurotropic analogues of biogenic monoamines in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine series were studied. It is shown that methyl substitution in the phenyl ring increases significantly the enzyme-substrate affinity, but the substituent's effect on the catalytic stage largely depends upon its position in the ring. o- and m-Methyl derivatives were preferably oxidized by B type of MAO, whereas p-total derivative was oxidized by B type as well as by A type of the enzyme. In the course of the oxidation reactions MAO is irreversibly inhibited by the dihydropyridinium product of the reaction, particularly in case of methyl derivatives. The significant and structure-dependent inhibition of the enzyme might be responsible for the differences in neurotropic properties of the above substrate homologues. 相似文献
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Bermisheva M. A. Kutuev I. A. Korshunova T. Yu. Dubova N. A. Villems R. Khusnutdinova E. K. 《Molecular Biology》2004,38(4):516-523
Analysis of mtDNA markers in a population of the Nogays (n = 206), the people inhabiting the North Caucasus and speaking a Turkic language of the Altaic linguistic family, has revealed
a high level of genetic diversity (H = 0.99). The identified haplotypes include all major West Eurasian haplogroups, with
the prevalence of H and U clusters (22 and 21%, respectively), but the percentage of lineages specific for East Eurasian populations
is the highest (40%). Some other mtDNA variants in the Nogay population belong to the M1 haplogroups typical of northeastern
Africa and U2 characteristic of Indian populations. Thus, components of different origin have contributed to the gene pool
of Nogays.
An erratum to this article is available at . 相似文献
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E A Kurbatova N B Egorova V G Dubova G M Davatdarova A A Lipats V B Gervazieva K G Kaverina 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1990,(5):53-56
Klebsiella vaccine, when injected subcutaneously to donors, proved to be faintly reactogenic and safe. The injection of the vaccine had no effect on changes in the morphological composition of peripheral blood and on liver function. In persons with the initially low content of IgG an increase in this characteristic was observed after immunization. No changes in the synthesis of IgE occurred in healthy donors under the influence of immunization. The vaccine was shown to be immunogenic when introduced according to immunization schedules comprising 3 and 5 injections, the titer of Klebsiella antibodies increasing 3- to 5-fold. 相似文献
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Balanovsky O Pocheshkhova E Pshenichnov A Solovieva D Kuznetsova M Voronko O Churnosov M Tegako O Atramentova L Lavryashina M Evseeva I Borinska S Boldyreva M Dubova N Balanovska E 《Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science》2005,24(4):375-382
It has been proposed that the Delta32 mutation in the chemokine receptor gene, inducing resistance to HIV-1 and, probably, to other virus infections, has undergone selection in historical times. The frequency of this mutant allele has changed rapidly both in time (during the last two millennia) and in space (across Eurasia). We compiled a global database on Delta32 allele frequencies in 300 populations. Nearly 10 percent of them are our data on 35 East European populations analyzed here for the first time. A detailed map of Delta32 frequency distribution was constructed and statistically analysed. We found a linearly decreasing trend with a maximum in areas surrounding the Baltic and White seas. Significant correlations with ground surface temperature were revealed. However, compared with our previous results, these correlations diminished, indicating that the influence of climate on Delta32 distribution was, if anything at all, indirect. The proposed scenario includes: i) arise and initial spread of the mutation among Uralic-speaking populations; ii) a frequency increase in northeastern Europe as a result of selection and/or genetic drift; iii) secondary spread (with selection continued) due to gene flow and the migrations of northern Europeans across the globe. 相似文献
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A. V. Sokolov M. V. Petoukhov K. M. Dubova S. V. Amarantov V. V. Volkov V. A. Kostevich N. P. Gorbunov N. A. Grudinina V. B. Vasilyev V. R. Samygina 《Biochemistry. Biokhimii?a》2018,83(6):701-707
Macrophage migration inhibitory factor (MIF) is a key proinflammatory cytokine. Inhibitors of tautomerase activity of MIF are perspective antiinflammatory compounds. Ceruloplasmin, the copper-containing ferroxidase of blood plasma, is a noncompetitive inhibitor of tautomerase activity of MIF in the reaction with p-hydroxyphenylpyruvate. Small-angle X-ray scattering established a model of the complex formed by MIF and ceruloplasmin. Crystallographic analysis of MIF with a modified active site supports the model. The stoichiometry of 3 CP/MIF trimer complex was established using gel filtration. Conformity of novel data concerning the interaction regions in the studied proteins with previous biochemical data is discussed. 相似文献