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Theoharides TC Alysandratos KD Angelidou A Delivanis DA Sismanopoulos N Zhang B Asadi S Vasiadi M Weng Z Miniati A Kalogeromitros D 《Biochimica et biophysica acta》2012,1822(1):21-33
Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of IL-33 and neurotensin. Mast cells can also release pro-inflammatory mediators selectively without degranulation. In particular, IL-1 induces selective release of IL-6, while corticotropin-releasing hormone secreted under stress induces the release of vascular endothelial growth factor. Many inflammatory diseases involve mast cells in cross-talk with T cells, such as atopic dermatitis, psoriasis and multiple sclerosis, which all worsen by stress. How mast cell differential responses are regulated is still unresolved. Preliminary evidence suggests that mitochondrial function and dynamics control mast cell degranulation, but not selective release. Recent findings also indicate that mast cells have immunomodulatory properties. Understanding selective release of mediators could explain how mast cells participate in numerous diverse biologic processes, and how they exert both immunostimulatory and immunosuppressive actions. Unraveling selective mast cell secretion could also help develop unique mast cell inhibitors with novel therapeutic applications. This article is part of a Special Issue entitled: Mast cells in inflammation. 相似文献
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Sismanopoulos N Delivanis DA Alysandratos KD Angelidou A Vasiadi M Therianou A Theoharides TC 《PloS one》2012,7(3):e33271
Interleukin 9 (IL-9) has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF) is involved. Here we report that IL-9 (10-20 ng/ml) induces gene expression and secretion of VEGF from human LAD2. IL-9 does not induce mast cell degranulation or the release of other mediators (IL-1, IL-8, or TNF). VEGF production in response to IL-9 involves STAT-3 activation. The effect is inhibited (about 80%) by the STAT-3 inhibitor, Stattic. Gene-expression of IL-9 and IL-9 receptor is significantly increased in lesional skin areas of atopic dermatitis (AD) patients as compared to normal control skin, while serum IL-9 is not different from controls. These results imply that functional interactions between IL-9 and mast cells leading to VEGF release contribute to the initiation/propagation of the pathogenesis of AD, a skin inflammatory disease. 相似文献
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Theoharis C. Theoharides Konstantinos-Dionysios Alysandratos Asimenia Angelidou Danae-Anastasia Delivanis Shahrzad Asadi Zuyi Weng Dimitrios Kalogeromitros 《生物化学与生物物理学报:疾病的分子基础》2012,1822(1):21-33
Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of IL-33 and neurotensin. Mast cells can also release pro-inflammatory mediators selectively without degranulation. In particular, IL-1 induces selective release of IL-6, while corticotropin-releasing hormone secreted under stress induces the release of vascular endothelial growth factor. Many inflammatory diseases involve mast cells in cross-talk with T cells, such as atopic dermatitis, psoriasis and multiple sclerosis, which all worsen by stress. How mast cell differential responses are regulated is still unresolved. Preliminary evidence suggests that mitochondrial function and dynamics control mast cell degranulation, but not selective release. Recent findings also indicate that mast cells have immunomodulatory properties. Understanding selective release of mediators could explain how mast cells participate in numerous diverse biologic processes, and how they exert both immunostimulatory and immunosuppressive actions. Unraveling selective mast cell secretion could also help develop unique mast cell inhibitors with novel therapeutic applications. This article is part of a Special Issue entitled: Mast cells in inflammation. 相似文献
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We have studied nasopharyngeal adenoids on standardized cephalometric radiograms of 25 children in each season. While individual subjects showed changes ranging from 1-17% throughout the year, a synchronized circannual rhythm could be described for the girls only. Similar changes were observed in boys, although a synchronized group rhythm could not be ascertained. No clear explanation for this apparent sexual dimorphism is known at this time, but different hormonal influences are likely. Evaluation of the nasopharyngeal airway (NPA) patency is thus affected by the season in which a cephalogram is taken. It should be noted that due to the described circannual rhythmicity, a single determination of the adenoid masses may be an insufficient and misleading indicator of the NPA obstruction. Etiology and clinical significance of these rhythmic changes need to be explored further. 相似文献
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