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1.
Wills M Akbar A Beswick M Bosch JA Caruso C Colonna-Romano G Dutta A Franceschi C Fulop T Gkrania-Klotsas E Goronzy J Griffiths SJ Henson S Herndler-Brandstetter D Hill A Kern F Klenerman P Macallan D Macualay R Maier AB Mason G Melzer D Morgan M Moss P Nikolich-Zugich J Pachnio A Riddell N Roberts R Sansoni P Sauce D Sinclair J Solana R Strindhall J Trzonkowski P van Lier R Vescovini R Wang G Westendorp R Pawelec G 《Immunity & ageing : I & A》2011,8(1):10-8
The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory frequency, inflation and immunosenescence; cytomegalovirus in aging, mortality and disease states; and the immunobiology of cytomegalovirus-specific T cells and effects of the virus on vaccination. This commentary summarizes the major findings of these presentations and references subsequently published work from the presenter laboratory where appropriate and draws together major themes that were subsequently discussed along with new areas of interest that were highlighted by this discussion. 相似文献
2.
Federico?LicastroEmail author Giuseppina?Candore Domenico?Lio Elisa?Porcellini Giuseppina?Colonna-Romano Claudio?Franceschi Calogero?Caruso 《Immunity & ageing : I & A》2005,2(1):8
The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at
a price when immunity is involved, namely systemic inflammation. Inflammation is not per se a negative phenomenon: it is the
response of the immune system to the invasion of viruses or bacteria and other pathogens. During evolution the human organism
was set to live 40 or 50 years; today, however, the immune system must remain active for much a longer time. This very long
activity leads to a chronic inflammation that slowly but inexorably damages one or several organs: this is a typical phenomenon
linked to ageing and it is considered the major risk factor for age-related chronic diseases. Alzheimer's disease, atherosclerosis,
diabetes and even sarcopenia and cancer, just to mention a few – have an important inflammatory component, though disease
progression seems also dependent on the genetic background of individuals. Emerging evidence suggests that pro-inflammatory
genotypes are related to unsuccessful ageing, and, reciprocally, controlling inflammatory status may allow a better chance
of successful ageing. In other words, age-related diseases are "the price we pay" for a life-long active immune system: this
system has also the potential to harm us later, as its fine tuning becomes compromised. Our immune system has evolved to control
pathogens, so pro-inflammatory responses are likely to be evolutionarily programmed to resist fatal infections with pathogens
aggressively. Thus, inflammatory genotypes are an important and necessary part of the normal host responses to pathogens in
early life, but the overproduction of inflammatory molecules might also cause immune-related inflammatory diseases and eventually
death later. Therefore, low responder genotypes involved in regulation of innate defence mechanisms, might better control
inflammatory responses and age-related disease development, resulting in an increased chance of long life survival in a "permissive"
environment with reduced pathogen load, medical care and increased quality of life. 相似文献
3.
G Biondi V Calabró S Colonna-Romano M Giangregorio P Malaspina R Petrucci C Santolamazza P Santolamazza E Tramontano G Battistuzzi 《Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur》1989,47(2):155-174
In the present paper we report on new data of the frequency of common and rare variants in the Italian population for ADA, AK-1, 6-PGD, EsA, EsB, EsD, PGM-1, PGM-2, SOD-A, AcP, GPT, and PGI. Moreover we present a comprehensive review of the available data on the electrophoretic variants of red cell enzymes in Italians. We find a considerable degree of genetic heterogeneity between the various populations living in the Peninsula and between the population of the Peninsula and of Sardinia. We also find that the estimates of the average heterozygosity are considerably smaller for the population of Sardinia as compared to Peninsula and Sicily. Finally, we report on the occurrence of several uncommon enzyme variants, which overall frequency is very similar to previously reported estimates for North European populations (Harris et al. 1974). 相似文献
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5.
Matteo Bulati Mariavaleria Pellicanò Sonya Vasto Giuseppina Colonna-Romano 《Immunity & ageing : I & A》2008,5(1):9
During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now
living in a rapidly ageing world. The sharp rise in life expectancy, coupled to a steady decline in birth rates in all developed
countries, has led to an unprecedented demographic revolution characterized by an explosive growth in the number and proportion
of older people. Ageing is a complex process that negatively impacts the development of the immune system and its ability
to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond
to immune challenge. These cumulative age-associated changes in immune competence are termed Immunosenescence: some immunological
parameters are commonly notably reduced in the elderly and, reciprocally good function is tightly correlated to health status.
Hence, a better understanding of Immunosenescence and the development of new strategies to counteract it are essential for
improving the quality of life of the elderly population. 相似文献
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7.
Carmela?R?BalistreriEmail author Giuseppina?Candore Giulia?Accardi Giuseppina?Colonna-Romano Domenico?Lio 《Immunity & ageing : I & A》2013,10(1):24
Chronic inflammation is a major biological mechanism underpinning biological ageing process and age-related diseases. Inflammation is also the key response of host defense against pathogens and tissue injury. Current opinion sustains that during evolution the host defense and ageing process have become linked together. Thus, the large array of defense factors and mechanisms linked to the NF-κB system seem to be involved in ageing process. This concept leads us in proposing inductors of NF-κB signaling pathway as potential ageing biomarkers. On the other hand, ageing biomarkers, represented by biological indicators and selected through apposite criteria, should help to characterize biological age and, since age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. In this report, some inflammatory biomarkers will be discussed for a better understanding of the concept of biological ageing, providing ideas on eventual working hypothesis about potential targets for the development of new therapeutic strategies and improving, as consequence, the quality of life of elderly population. 相似文献
8.
Calogero Caruso Silvio Buffa Giuseppina Candore Giuseppina Colonna-Romano Deborah Dunn-Walters David Kipling Graham Pawelec 《Immunity & ageing : I & A》2009,6(1):10-4
On April 7,8, 2009 a Symposium entitled "Pathophysiology of Successful and Unsuccessful Ageing" took place in Palermo, Italy.
Here, the lectures of G. Pawelec, D. Dunn-Walters and. G. Colonna-Romano on T and B immunosenescence are summarized. In the
elderly, many alterations of both innate and acquired immunity have been described. Alterations to the immune system in the
older person are generally viewed as a deterioration of immunity, leading to the use of the catch-all term immunosenescence.
Indeed, many immunological parameters are often markedly different in elderly compared to young people, and some, mostly circumstantial,
evidence suggests that retained function of both innate and acquired immunity in the elderly is correlated with health status.
What is often not clear from studies is how far immune dysfunction is a cause or an effect. A better understanding of immunosenescence
and mechanisms responsible for proven deleterious changes is needed to maintain a healthy state in later life and to design
possible therapeutic interventions. 相似文献
9.
Genetic heterogeneity at the glucose-6-phosphate dehydrogenase locus in southern Italy: a study on the population of Naples 总被引:3,自引:0,他引:3
Colonna-Romano S. Iolascon A. Lippo S. Pinto L. Cutillo S. Battistuzzi G. 《Human genetics》1985,69(3):228-232
Summary Glucose-6-phosphate dehydrogenase (G6PD) electrophoretic phenotype was determined in red cells from 979 male subjects born in Naples (Southern Italy). In 0.7% of the cases no activity could be detected in haemolysates, while in 1.3% of the cases G6PD activity was approximately 20% of normal and electrophoretic mobility was altered. Moveover in two subjects a G6PD with altered mobility and normal activity was shown. G6PD was characterized in 10 subjects with variant phenotype. We conclude that the G6PD(-) phenotype in the population of Naples consists of at least six different G6PD variants associated with mild deficiency and at least one, G6PD Mediterranean, associated with severe deficiency. 相似文献
10.
Balistreri CR Candore G Accardi G Bova M Buffa S Bulati M Forte GI Listì F Martorana A Palmeri M Pellicanò M Vaccarino L Scola L Lio D Colonna-Romano G 《Immunity & ageing : I & A》2012,9(1):8-10
ABSTRACT: The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and unsuccessful ageing". They are equipped to reach the extreme limits of human life span and, most importantly, to show relatively good health, being able to perform their routine daily life and to escape fatal age-related diseases, such as cardiovascular diseases and cancer. Thus, particular attention has been centered on their genetic background and immune system. In this review, we report our data gathered for over 10 years in Sicilian centenarians. Based on results obtained, we suggest longevity as the result of an optimal performance of immune system and an over-expression of anti-inflammatory sequence variants of immune/inflammatory genes. However, as well known, genetic, epigenetic, stochastic and environmental factors seem to have a crucial role in ageing and longevity. Epigenetics is associated with ageing, as demonstrated in many studies. In particular, ageing is associated with a global loss of methylation state. Thus, the aim of future studies will be to analyze the weight of epigenetic changes in ageing and longevity. 相似文献