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Stankova Ivanka Chuchkov Kiril Chayrov Radoslav Mukova Luchia Galabov Angel Marinkova Desislava Danalev Dancho 《International journal of peptide research and therapeutics》2020,26(4):1781-1787
International Journal of Peptide Research and Therapeutics - Herein, we report design and synthesis of series of adamantane derivatives containing modified peptides with thiazol moiety. New... 相似文献
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Kiril Chuchkov Radoslav Chayrov Anton Hinkov Daniel Todorov Kalina Shishkova Ivanka G. Stankova 《Nucleosides, nucleotides & nucleic acids》2020,39(7):979-990
АBSTRACTEsters of the antiherpetic drugs ganciclovir, penciclovir with the bile acids (cholic, chenodeoxycholic and deoxycholic) and amino acid esters of acyclovir were generated and evaluated for their in vitro antiviral activity against herpes simplex viruses type 1 and type 2 (HSV-1, HSV-2). The antiviral assays demonstrated that modified analogs of ACV and PCV are less active compared to the initial substances against HSV-1and HSV-2. CC50 for ganciclovir-deoxycholate corresponded to the CC50 of the other analogs and its activity is lower than ganciclovir. Obtained results show that tested modification do not improve bioavailability of nucleoside analogs in cells. 相似文献
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