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Nayak Ananta Kumar Gou Zhe Das Sovan Lal Barakat Abdul I. Misbah Chaouqi 《Biomechanics and modeling in mechanobiology》2023,22(1):217-232
Biomechanics and Modeling in Mechanobiology - Calcium is a ubiquitous molecule and second messenger that regulates many cellular functions ranging from exocytosis to cell proliferation at different... 相似文献
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We report on the rheology of dilute suspensions of red blood cells (RBC) and vesicles. The viscosity of RBC suspensions reveals a previously unknown signature: it exhibits a pronounced minimum when the viscosity of the ambient medium is close to the value at which the transition from tank-treading to tumbling occurs. This bifurcation is triggered by varying the viscosity of the ambient fluid. It is found that the intrinsic viscosity of the suspension varies by about a factor of 4 in the explored parameter range. Surprisingly, this significant change of the intrinsic viscosity is revealed even at low hematocrit (5%). We suggest that this finding may be used to detect blood flow disorders linked to pathologies that affect RBC shape and mechanical properties. This opens future perspectives on setting up new diagnostic tools, with great efficiency even at very low hematocrit. Investigations are also performed on giant vesicle suspensions, and compared to RBCs. 相似文献
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Ga?l Prado Alexander Farutin Chaouqi Misbah Lionel Bureau 《Biophysical journal》2015,108(9):2126-2136
The unique ability of a red blood cell to flow through extremely small microcapillaries depends on the viscoelastic properties of its membrane. Here, we study in vitro the response time upon flow startup exhibited by red blood cells confined into microchannels. We show that the characteristic transient time depends on the imposed flow strength, and that such a dependence gives access to both the effective viscosity and the elastic modulus controlling the temporal response of red cells. A simple theoretical analysis of our experimental data, validated by numerical simulations, further allows us to compute an estimate for the two-dimensional membrane viscosity of red blood cells, ∼ 10−7 N⋅s⋅m−1. By comparing our results with those from previous studies, we discuss and clarify the origin of the discrepancies found in the literature regarding the determination of , and reconcile seemingly conflicting conclusions from previous works. 相似文献
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Hogan Brenna Shen Zaiyi Zhang Hengdi Misbah Chaouqi Barakat Abdul I. 《Biomechanics and modeling in mechanobiology》2019,18(4):1095-1109
Biomechanics and Modeling in Mechanobiology - The effect of red blood cells and the undulation of the endothelium on the shear stress in the microvasculature is studied numerically using the... 相似文献
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