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The frequency of the GSTM1 gene deletion homozygotes in eight populations of the Volga-Ural region belonging according to linguistic classification to Turkic (Bashkirs, Tatars, and Chuvashs), Finno-Ugric (Maris, Komis, Mordovians, and Udmurts), and Eastern-Slavic (Russians) ethnic groups, was examined by means of PCR technique. The frequency of the deletion homozygotes varied from 41.4% in Bashkirs to 61.3% in Mordovians. The mean deletion frequency comprised 50.1%, which was consistent with the data for European populations (chi 2 = 0.009). 相似文献
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Bikmaeva A. R. Sibiryak S. V. Valiakhmetova D. Kh. Khusnutdinova E. K. 《Molecular Biology》2002,36(5):631-633
The polymorphism at position –308 of the TNF- gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls (2 = 11.69, p = 0.001), suggesting association of this allele with higher risk of pulmonary tuberculosis or with markedly disturbed immune response. 相似文献
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Polymorphism of the tumor necrosis factor alpha gene in patients with infiltrative tuberculosis and from the Bashkorstan populations 总被引:1,自引:0,他引:1
Bikmaeva AR Sibiriak SV Valiakhmetova DKh Khusnutdinova EK 《Molekuliarnaia biologiia》2002,36(5):784-787
The polymorphism at position -308 of the TNF-alpha gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls (chi 2 = 11.69, p = 0.001), suggesting an association of this allele with higher risk of pulmonary tuberculosis or a disturbed immune response. 相似文献
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Insertion polymorphism Ins96 of the CYP2E1 promoter region was for the first time studied in three ethnic groups of Bashkortostan. Population-specific features of genotype and allele frequency distributions were observed. The CYP2E1 polymorphism was associated with infiltrative pulmonary tuberculosis in the Bashkortostan population. 相似文献
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Vakhitova Yu. V. Soultanaeva Z. M. Viktorova T. V. Bikmaeva A. R. Khusnutdinova E. K. 《Russian Journal of Genetics》2001,37(2):202-204
The frequency of the GstM1 gene deletion homozygotes in eight populations of the Volga–Ural region belonging according to linguistic classification to Turkic (Bashkirs, Tatars, and Chuvashs), Finno–Ugric (Maris, Komis, Mordovians, and Udmurts), and Eastern–Slavic (Russians) ethnic groups, was examined by means of PCR technique. The frequency of the deletion homozygotes varied from 41.4% in Bashkirs to 61.3% in Mordovians. The mean deletion frequency comprised 50.1%, which was consistent with the data for European populations (2= 0.009). 相似文献
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Insertion polymorphism Ins96 of the CYP2E1 promoter region was for the first time studied in three ethnic groups of Bashkortostan. Population-specific features of genotype and allele frequency distributions were observed. The CYP2E1 polymorphism was associated with infiltrative pulmonary tuberculosis in the Bashkortostan population. 相似文献
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