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Comparative expression analysis of hypoxia‐inducible factor‐alpha and its natural occurring antisense in breast cancer tissues and adjacent noncancerous tissues 下载免费PDF全文
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Simzar Hosseinzadeh Hojjatollah Nazari Negar Sadegzadeh Ali Babaie Mahboubeh Kabiri Noshin Tasharrofi Mahsa Soufi Zomorrod Masoud Soleimani 《Journal of cellular biochemistry》2019,120(2):1511-1521
Among different tissues, endothelial/cardiac types require specific factors to promote myocardial regeneration after occurred injuries. Herein, cardiac stem cells (CSCs) as the major cell population that involved in cardiovascular repair were selected to study the role of polyethyleneimine (PEI) agent on endothelial differentiation. After preparation of electrospun network of PEI with polyacrylonitrile, the related characterizations were carried out including scanning electron microscope (SEM), field-emission SEM, water contact angle, Fourier transform infrared spectroscopy and mechanical properties. Also, the release kinetic of the corresponding agent was studied up to 7 days. The cell differentiation studies were done in the following with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, Real-time polymerase chain reaction and immunostaining method. The whole obtained results approved the higher differentiation of CSCs into endothelial/cardiac cells. Finally, it is recommended that the PEI delivering increases the healing potency of CSCs and accordingly the regeneration speed of damaged cardiovascular tissue would be improved. 相似文献
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Survival Improvement in Human Retinal Pigment Epithelial Cells via Fas Receptor Targeting by miR‐374a 下载免费PDF全文
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Azam Khedri Amireh Nejat-Shokouhi Roham Salek Habibollah Esmaeili Ali Mokhtarifar Reza Entezari Heravi Farnoosh Tatari Javad Behravan Behnoosh Miladpour Shahireh Omidvar Tehrani 《Molecular biology reports》2011,38(5):2939-2943
The human multidrug resistance (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics,
bacterial toxins, drugs and other biologically active compounds, possibly carcinogens. In this study, an association of MDR1 gene polymorphism and the occurrence of colorectal cancer were evaluated. In this case-control-designed 118 unrelated colorectal
cancer and 137 sex-and-ages matched healthy controls were enrolled. The C3435T MDR1 gene polymorphism was identified using the polymerase chain reaction-restriction fragment length polymorphism method. Significantly
increased frequencies of the 3435T allele and the 3435TT were observed in patients with colorectal cancer compared with controls
(P = 0.03; OR, 95% CI; 1.46 for 3435T allele and P = 0.003; OR, 95% CI; 2.2 for 3435TT genotype). In contrast, frequency of genotype TT was significantly higher in controls
compared to colorectal cancer (P = 0.006; OR, 95% CI; 0.49 for TC genotype). In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer. The results support that the presence of allele C results in decreased
susceptibility to colorectal cancer. 相似文献
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Functional SNP in microRNA‐491‐5p binding site of MMP9 3′‐UTR affects cancer susceptibility 下载免费PDF全文
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Nowrouzi-Sohrabi Peyman Seghatoleslam Atefeh Kalani Mehdi Erfani Mehran Hosseini Abgir Alireza Hatami Shekoufeh Namdar Mahdi Tahmasebi Mohammadjavad Miladpour Behnoosh 《Molecular biology reports》2022,49(5):3453-3459
Molecular Biology Reports - Plasmacytoma variant translocation 1 (PVT1) is a newly discovered long non-coding RNA, which has not been previously studied in the inflammatory responses of the... 相似文献
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