排序方式: 共有9条查询结果,搜索用时 187 毫秒
1
1.
O. B. Flekhter L. T. Karachurina V. V. Poroikov L. P. Nigmatullina L. A. Baltina F. S. Zarudii V. A. Davydova L. V. Spirikhin I. P. Baikova F. Z. Galin G. A. Tolstikov 《Russian Journal of Bioorganic Chemistry》2000,26(3):192-200
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, andp-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin
esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor.
These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bishemiphthalate
was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol. 相似文献
2.
O. B. Kazakova I. E. Smirnova E. F. Khusnutdinova O. S. Zhukova L. V. Fetisova G. N. Apryshko N. I. Medvedeva E. Yu. Yamansarov I. P. Baikova Thanh Tra Nguyen H. Do Thi Thu 《Russian Journal of Bioorganic Chemistry》2014,40(5):558-567
A variety of oxygen-, nitrogen-, sulfur-, and platinum-containing allobetulin derivatives, including those with different positions of double bonds in rings A and B, the penta- and hexacyclic ring A, and the 21-acetyl-20,28-epoxy-18α,19βH-ursanoisomeric cycle E, have been synthesized, and the screening of their antineoplastic activity in vitro (cytotoxicity) has been carried out. A significant cytotoxic activity was exhibited by (3R,5R)-19β,28-epoxy-4,5-seco-18α-olean-3(5)-ozonide toward MeWo melanoma cells and by 2,3-indolo-21β-acetyl-20β,28-epoxy-18α,19βH-ursane toward SR leukosis cells. The 3S,5S-diastereoisomer of the former compound showed no cytotoxicity. 相似文献
3.
O. B. Kazakova N. I. Medvedeva I. P. Baikova G. A. Tolstikov T. V. Lopatina M. S. Yunusov L. Zaprutko 《Russian Journal of Bioorganic Chemistry》2010,36(6):771-778
The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic
acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the
selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral
pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11)
was detected with the selectivity index SI 35. 相似文献
4.
O. B. Kazakova G. V. Giniyatullina N. I. Medvedeva T. V. Lopatina I. P. Baikova G. A. Tolstikov G. N. Apryshko 《Russian Journal of Bioorganic Chemistry》2014,40(2):198-205
3-Deoxy-3a-homo-3a-aza derivatives of betulin and erythrodiol have been synthesized from betulonic and oleanonic acids. 3-Deoxy-3a-homo-3a-aza-28-hydroxy-12(13)-oleanene showed the highest antineoplastic activity of the broad spectrum in vitro; the results of an extensive examination of the derivative in vitro enable one to recommend it for in vivo tests. The modification of the compound in the position C28 by the introduction of a methoxycinnamoyl fragment led to the loss of the antineoplastic activity. As a whole, 3-deoxy-3a-homo-3a-aza derivatives of betulin [3-(aminopropyl)-, 28-(2-carboxyethyl)carboxy-, and 28-cinamoyloxy-] exhibited a moderate antineoplastic activity toward large intestine cancer, breast cancer, and leukemia cells. 相似文献
5.
Lopatina T. V. Medvedeva N. I. Baikova I. P. Iskhakov A. S. Kazakova O. B. 《Russian Journal of Bioorganic Chemistry》2019,45(4):292-301
Russian Journal of Bioorganic Chemistry - A five-stage synthesis of azepanobetulin from betulin with a total yield of 47% has been carried out. The acylation of azepanobetulin with anhydrides or... 相似文献
6.
Eva Csefalvay Mikalai Lapkouski Alena Guzanova Ladislav Csefalvay Tatsiana Baikova Igor Shevelev Vitali Bialevich Katsiaryna Shamayeva Pavel Janscak Ivana Kuta Smatanova Santosh Panjikar Jannette Carey Marie Weiserova Rüdiger Ettrich 《PloS one》2015,10(6)
Type I restriction-modification enzymes are multifunctional heteromeric complexes with DNA cleavage and ATP-dependent DNA translocation activities located on motor subunit HsdR. Functional coupling of DNA cleavage and translocation is a hallmark of the Type I restriction systems that is consistent with their proposed role in horizontal gene transfer. DNA cleavage occurs at nonspecific sites distant from the cognate recognition sequence, apparently triggered by stalled translocation. The X-ray crystal structure of the complete HsdR subunit from E. coli plasmid R124 suggested that the triggering mechanism involves interdomain contacts mediated by ATP. In the present work, in vivo and in vitro activity assays and crystal structures of three mutants of EcoR124I HsdR designed to probe this mechanism are reported. The results indicate that interdomain engagement via ATP is indeed responsible for signal transmission between the endonuclease and helicase domains of the motor subunit. A previously identified sequence motif that is shared by the RecB nucleases and some Type I endonucleases is implicated in signaling. 相似文献
7.
Alexander V. Tyakht Alexander I. Manolov Alexandra V. Kanygina Dmitry S. Ischenko Boris A. Kovarsky Anna S. Popenko Alexander V. Pavlenko Anna V. Elizarova Daria V. Rakitina Julia P. Baikova Valentina G. Ladygina Elena S. Kostryukova Irina Y. Karpova Tatyana A. Semashko Andrei K. Larin Tatyana V. Grigoryeva Mariya N. Sinyagina Sergei Y. Malanin Petr L. Shcherbakov Anastasiya Y. Kharitonova Igor L. Khalif Marina V. Shapina Igor V. Maev Dmitriy N. Andreev Elena A. Belousova Yulia M. Buzunova Dmitry G. Alexeev Vadim M. Govorun 《BMC genomics》2018,19(1):968
Background
Crohn’s disease is associated with gut dysbiosis. Independent studies have shown an increase in the abundance of certain bacterial species, particularly Escherichia coli with the adherent-invasive pathotype, in the gut. The role of these species in this disease needs to be elucidated.Methods
We performed a metagenomic study investigating the gut microbiota of patients with Crohn’s disease. A metagenomic reconstruction of the consensus genome content of the species was used to assess the genetic variability.Results
The abnormal shifts in the microbial community structures in Crohn’s disease were heterogeneous among the patients. The metagenomic data suggested the existence of multiple E. coli strains within individual patients. We discovered that the genetic diversity of the species was high and that only a few samples manifested similarity to the adherent-invasive varieties. The other species demonstrated genetic diversity comparable to that observed in the healthy subjects. Our results were supported by a comparison of the sequenced genomes of isolates from the same microbiota samples and a meta-analysis of published gut metagenomes.Conclusions
The genomic diversity of Crohn’s disease-associated E. coli within and among the patients paves the way towards an understanding of the microbial mechanisms underlying the onset and progression of the Crohn’s disease and the development of new strategies for the prevention and treatment of this disease.8.
The paper reports on distribution of 8 wild barberry species in phytogeographic regions of Tajikistan, specifies altitudinal
limits of the barberry species and vegetation types the species are components of. 相似文献
9.
O. B. Kazakova G. V. Giniyatullina G. A. Tolstikov I. P. Baikova L. Zaprutko G. N. Apryshko 《Russian Journal of Bioorganic Chemistry》2011,37(3):369-379
Aminopropoxy derivatives of betulin, erythrodiol, uvaol, and oleantriol have been synthesized by the cyanoethylation of the
hydroxyl groups of triterpenoids with the subsequent reduction of cyanoethyl fragments. It has been found that 3β,28-di-O-[3-(aminopropoxy)]lupa-20(29)-ene and 3β-O-hydroxy-28-O-[3-(aminopropoxy)]olean-12-ene possess high in vitro antitumor activity toward a wide range of human tumor cell lines. It has been shown that the aminopropoxy fragment is a novel
promising pharmacophore group in the synthesis of anticancer agents based on triterpenoids. 相似文献
1