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1.
Zahid H. Chohan Humayun Pervez A. Rauf Khalid M. Khan Ghulam M. Maharvi 《Journal of enzyme inhibition and medicinal chemistry》2013,28(2):161-168
A new series of antibacterial and antifungal triazine-derived mono- and di-substituted (symmetrical and unsymmetrical) Schiff-bases and their cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments and IR and electronic spectral measurements. IR spectra indicated the ligands to act as tridentate towards divalent metal ions via a trazine-N, the azomethine-N and, indole-NH and deprotonated-O of salicylaldehyde. The magnetic moments and electronic spectral data suggest octahedral geometry for the Co(II), Ni(II) and Zn(II)complexes and square-pyramid for Cu(II) complexes. NMR spectral data of the ligands and their diamagnetic zinc(II) complexes well-define their proposed structures/geometries. Elemental analyses data of the ligands and metal complexes agree with their proposed structures/geometries. The synthesized ligands, along with their metal complexes were screened for their antibacterial activity against Escherichia coli, Bacillus subtillis, Shigella flexneri, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. The results of these studies show the metal complexes to be more antibacterial/antifungal against two or more species as compared to the uncomplexed Schiff-base ligands. 相似文献
2.
Humayun Pervez Mohammad S. Iqbal Muhammad Younas Tahir Faiz-ul-Hassan Nasim Muhammad Iqbal Choudhary Khalid Mohammed Khan 《Journal of enzyme inhibition and medicinal chemistry》2013,28(6):848-854
A series of 15 previously reported N4-substituted isatin-3-thiosemicarbazones 3a-o has been screened for cytotoxic, antibacterial, antifungal and urease inhibitory activities. Compounds 3b, 3e and 3n proved to be active in cytotoxicity assay; 3e exhibited a high degree of cytotoxic activity (LD50 = 1.10 × 10? 5 M). Compound 3h exhibited significant antibacterial activity against B. subtilis, whereas compounds 3a, 3k and 3l displayed significant antifungal activity against one or more fungal strains i.e. T. longifusus, A. flavus and M. canis. In human urease enzyme inhibition assay, compounds 3g, 3k and 3m proved to be the most potent inhibitors, exhibiting relatively pronounced inhibition of the enzyme. These compounds, being non-toxic, could be potential candidates for orally effective therapeutic agents to treat certain clinical conditions induced by bacterial ureases like H. pylori urease. This study presents the first example of inhibition of urease by isatin-thiosemicarbazones and as such provides a solid basis for further research on such compounds to develop more potent inhibitors. 相似文献
3.
Robert E. Brainard Lewis J. Watson Angelica M. DeMartino Kenneth R. Brittian Ryan D. Readnower Adjoa Agyemang Boakye Deqing Zhang Joseph David Hoetker Aruni Bhatnagar Shahid Pervez Baba Steven P. Jones 《PloS one》2013,8(12)
Preclinical studies of animals with risk factors, and how those risk factors contribute to the development of cardiovascular disease and cardiac dysfunction, are clearly needed. One such approach is to feed mice a diet rich in fat (i.e. 60%). Here, we determined whether a high fat diet was sufficient to induce cardiac dysfunction in mice. We subjected mice to two different high fat diets (lard or milk as fat source) and followed them for over six months and found no significant decrement in cardiac function (via echocardiography), despite robust adiposity and impaired glucose disposal. We next determined whether antecedent and concomitant exposure to high fat diet (lard) altered the murine heart’s response to infarct-induced heart failure; high fat feeding during, or before and during, heart failure did not significantly exacerbate cardiac dysfunction. Given the lack of a robust effect on cardiac dysfunction with high fat feeding, we then examined a commonly used mouse model of overt diabetes, hyperglycemia, and obesity (db/db mice). db/db mice (or STZ treated wild-type mice) subjected to pressure overload exhibited no significant exacerbation of cardiac dysfunction; however, ischemia-reperfusion injury significantly depressed cardiac function in db/db mice compared to their non-diabetic littermates. Thus, we were able to document a negative influence of a risk factor in a relevant cardiovascular disease model; however, this did not involve exposure to a high fat diet. High fat diet, obesity, or hyperglycemia does not necessarily induce cardiac dysfunction in mice. Although many investigators use such diabetes/obesity models to understand cardiac defects related to risk factors, this study, along with those from several other groups, serves as a cautionary note regarding the use of murine models of diabetes and obesity in the context of heart failure. 相似文献
4.
Rashid Pervez 《Archives Of Phytopathology And Plant Protection》2013,46(5):318-327
Abstract Observations were made on the attraction of Aporcelaimellus nivalis towards kairomones/attractants emitted by prey nematodes belonging to different trophic categories, viz., saprophagous, epidermal, migratory semi-endodermal, predatory nematodes, virus vectors and cortical feeders. Aporcelaimellus nivalis responded positively and significantly to prey kairomones, but showed variation in their individual behaviour. Predators are most attracted towards epidermal feeders and least attracted to virus vectors. The differential responses of A. nivalis towards different prey were attributed to the inert behaviour of predators, their preference for a particular species of prey, chemical composition, concentration, quality, quantity of prey attractant, formation of minimum perceptible attraction gradient of prey and minimum response threshold of predators. Various factors such as prey density, period of prey incubation, starvation of predators, temperature, agar concentration, agar thickness and distance of predators from the source of attraction (prey) govern chemosensory responses of predator. Aporcelaimellus nivalis maximum response was towards Hirschmanniella oryzae, when tested as 10 day starved predators in agar plates containing 2 mm thick layer of 1% water-agar with 200 prey individuals previously incubated for 16 h at 30°C. Prey kairomones were most attractive when A. nivalis were tested from a distance of 2 and 3 cm. 相似文献
5.
S. S. Ali R. Pervez M. Abid Hussain R. Ahmad 《Archives Of Phytopathology And Plant Protection》2013,46(4):300-304
Abstract An investigation was conducted in pots to access the susceptibility of three lepidopteran pests, namely, gram pod borer, Helicoverpa armigera, greater wax moth, Galleria mellonella, and rice moth, Corcyra cephalonica, to two recently described species, Steinernema masoodi, S. seemae, and three indigenous S. carpocapsae, S. glaseri and S. thermophilum entomopathogenic nematodes (EPN). The suitability of these lepidopterans for the in vivo mass production of the nematodes was also estimated. Among the five species of EPN, S. masoodi, S. seemae and S. carpocapsae were found most pathogenic to C. cephalonica, bringing about mortality within 24 h, followed by H. armigera (36, 38 and 48 h, respectively) and G. mellonella (30, 36 and 48 h, respectively). The other species of EPN, viz., S. glaseri and S. thermophilum was the least pathogenic, which killed the larvae of C. cephalonica in 29 and 36 h, respectively, G. mellonella in 48 h, and H. armigera in 38 and 56 h, respectively. Galleria mellonella was found the most suitable host for the mass production of infective juveniles (IJs) of S. seemae, which yielded higher IJs than S. carpocapsae. Helicoverpa armigera was the next best suitable alternate host, which produced maximum IJs in case of S. seemae followed by S. masoodi, S. carpocapsae, S. glaseri and S. thermophilum. Rice moth, Corcyra cephalonica was the least suitable host. The susceptibility of H. armigera to five tested EPN species and susceptibility of G. mellonella and C. cephalonica to S. masoodi and S. seemae are new records. 相似文献
6.
Peerzada Yasir Yousuf Altaf Ahmad Ibrahim M. Aref Munir Ozturk Hemant Arshid Hussain Ganie Muhammad Iqbal 《Protoplasma》2016,253(6):1565-1575
Brassica juncea is mainly cultivated in the arid and semi-arid regions of India where its production is significantly affected by soil salinity. Adequate knowledge of the mechanisms underlying the salt tolerance at sub-cellular levels must aid in developing the salt-tolerant plants. A proper functioning of chloroplasts under salinity conditions is highly desirable to maintain crop productivity. The adaptive molecular mechanisms offered by plants at the chloroplast level to cope with salinity stress must be a prime target in developing the salt-tolerant plants. In the present study, we have analyzed differential expression of chloroplast proteins in two Brassica juncea genotypes, Pusa Agrani (salt-sensitive) and CS-54 (salt-tolerant), under the effect of sodium chloride. The chloroplast proteins were isolated and resolved using 2DE, which facilitated identification and quantification of 12 proteins that differed in expression in the salt-tolerant and salt-sensitive genotypes. The identified proteins were related to a variety of chloroplast-associated molecular processes, including oxygen-evolving process, PS I and PS II functioning, Calvin cycle and redox homeostasis. Expression analysis of genes encoding differentially expressed proteins through real time PCR supported our findings with proteomic analysis. The study indicates that modulating the expression of chloroplast proteins associated with stabilization of photosystems and oxidative defence plays imperative roles in adaptation to salt stress. 相似文献
7.
Chohan ZH Pervez H Khan KM Rauf A Supuran CT 《Journal of enzyme inhibition and medicinal chemistry》2004,19(1):51-56
A method is described for the preparation of novel cephalexin-derived furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-containing compounds showing potent antibacterial activity. The binding of these newly synthesized antibacterial agents with metal ions such as cobalt(II), copper(II), nickel(II) and zinc(II) has been studied and their inhibitory properties against various bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae are also reported. These results suggest that metal ions to possess an important role in the designing of metal-based antibacterials and that such complexes are more effective against infectious diseases compared to the uncomplexed drugs. 相似文献
8.
Muhammad Irshad Sajjad Ahmad Arshid Pervez Mitsuhiro Inoue 《International journal of phytoremediation》2015,17(2):154-158
The objective of this research was to compare the potential of native plants for the phytoaccumulation of heavy metals (HM). Thirteen predominant plant species (including trees, bushes and grasses) namely Ricinus communis, Ipomoea carnea, Cannabis sativa, Parthenium hysterophorus, Acacia nilotica, Dalbergia sissoo, Acacia modesta, Solanum nigrum, Xanthium stromarium, Chenopodium album, Cynodon dactylon, Eleusine indica, and Dactyloctenium aegyptium were collected from the wastewater originated from Hattar industrial estate of Pakistan, Plants shoots and roots were analyzed for heavy metals / metalloid: Pb, Cr, Cd, Zn, Fe, Ni, and As. Among plant species, the accumulation potential for HM varied depending on the type of element. Regardless of the plant species, HM concentrations varied in the order of Fe > Zn > Cr > Pb > Ni > Cd > As. Tree species of R. communis, A. nilotica, A. modesta, and D. sissoo exhibited an enhanced concentrations of metals. Accumulation pattern of Fe, Pb, Cd, and As in plants could be related to the HM composition of soil and wastewater. Most of the species exhibited higher HM composition in the root as compared to shoot. The species that found with greater ability to absorb HM in the root, got higher HM concentrations in its shoot. Shoot tissue concentrations of HM were attained by the species as D. sissoo > A. modesta > A. nilotica > R. communis > I. carnea > C. album > E. indica > P. hysterophorus > S. nigrum > C. sativa > D. aegyptium > X. strumarium > C. dactylon. Based on results, tree plants were noticed as higher accumulators of HM in polluted soils. 相似文献
9.
Arshid Hussain Ganie Altaf Ahmad Renu Pandey Ibrahim M. Aref Peerzada Yasir Yousuf Sayeed Ahmad Muhammad Iqbal 《PloS one》2015,10(6)
Background
Maize (Zea mays L.) is one of the most widely cultivated crop plants. Unavoidable economic and environmental problems associated with the excessive use of phosphatic fertilizers demands its better management. The solution lies in improving the phosphorus (P) use efficiency to sustain productivity even at low P levels. Untargeted metabolomic profiling of contrasting genotypes provides a snap shot of whole metabolome which differs under specific conditions. This information provides an understanding of the mechanisms underlying tolerance to P stress and the approach for increasing P-use-efficiency.Methodology/Principal Findings
A comparative metabolite-profiling approach based on gas chromatography-mass spectrometry (GC/MS) was applied to investigate the effect of P starvation and its restoration in low-P sensitive (HM-4) and low-P tolerant (PEHM-2) maize genotypes. A comparison of the metabolite profiles of contrasting genotypes in response to P-deficiency revealed distinct differences among low-P sensitive and tolerant genotypes. Another set of these genotypes were grown under P-restoration condition and sampled at different time intervals (3, 5 and 10 days) to investigate if the changes in metabolite profile under P-deficiency was restored. Significant variations in the metabolite pools of these genotypes were observed under P-deficiency which were genotype specific. Out of 180 distinct analytes, 91 were identified. Phosphorus-starvation resulted in accumulation of di- and trisaccharides and metabolites of ammonium metabolism, specifically in leaves, but decreased the levels of phosphate-containing metabolites and organic acids. A sharp increase in the concentrations of glutamine, asparagine, serine and glycine was observed in both shoots and roots under low-P condition.Conclusion
The new insights generated on the maize metabolome in resposne to P-starvation and restoration would be useful towards improvement of the P-use efficiency in maize. 相似文献10.
Ahmad Pervez 《Journal of Asia》2011,14(3):357-365
Herein, the ecology of genus Propylea, with special reference to its three species — viz. P. dissecta (Mulsant), P. japonica (Thunberg), and P. quatuordecimpunctata Linnaeus is reviewed, with an eye toward its position in natural habitats and amongst other ladybirds and its biocontrol potential. Although Propylea is not as polyphagous as other successful species, it evidences a preference for certain prey, specifically aphids and whiteflies. This genus is a good model for studies of mating, reproduction, sexual selection, etc. Propylea is usually an intraguild prey in the guilds containing ladybirds, such as Harmonia axyridis (Pallas) and Coccinella septempunctata L. It also appears that it retains some intrinsic advantages that aid in the sustenance and survival of the species. Owing to its smaller size and level of victimization in the guild, its biocontrol potential is questionable, but its size disadvantages are counter-balanced by its high intrinsic rate of increase, high predation, reproductive potential, and bioconversion efficiency, as well as the ease with which it can be reared in the laboratory. Further research will be necessary to ascertain clearly the biocontrol potential of Propylea. 相似文献