云南省角蝉科二新属二新种

最近我们从全国动物学科研单位和高等院校借调来大批的角蝉科标本,进行系统的分类研究,从中发现有二新属及二新种,均采自云南西双版纳,现在先把它们加以记载。     

角蝉科一新属一新种

角蝉科的昆虫,是世界著名的富于拟态性的昆虫。它们的畸形发达的前胸背板给人们以明显的识别的特征。这一科不少种类是果树、森林或农业的重要害虫,造成相当严重的灾害。角蝉科截至目前为止,全世界已记载的共324属2500余种;中国已知的20属152种。 本文记述角蝉科一新属及一新种。     

金翅夜蛾亚科的研究

近年来,我们又获得大量金翅夜蛾亚科的标本。这些标本有的是我们区系组的同志从全国各地采集的,有的是兄弟单位赠送或借给的。 标本共77,085号,我们逐一进行了外部特征的观察,每种作了雌雄生殖器的解剖研究。除前一报告已记载的相同种类外,新增加的种类有36种。如下:     

中国的广翅蜡蝉科附八新种

广翅蜡蝉科的种类,多数为害木本植物,少数为害禾本科草本植物,有的是果树、森林和农作物的害虫。但关于广翅蜡蝉科的研究,过去很不充分,我国的种类、分布与寄主关系,至今还不清楚。1935年胡经甫的昆虫名录中列入11种(包括3种同物异名),1959年《中国果树病虫志》中列了5种。 我们根据三十年来在全国各地的采集调查,和全国兄弟单位提供的标本,共鉴定出26种。本文着重记录它们的分布及其为害植物,并记载新种8种。     

金翅夜蛾亚科八新种及一些种类的订正

金翅夜蛾亚科的种类,有的在外形上非常相似,因之过去文献记载常有混淆的地方和鉴定上的错误。本文讨论了一些种类的区别,纠正某些错误的记载,并报道8个新种。 所有新种的模式标本都暂在西北农学院昆虫标本室保存。     

金翅夜蛾亚科Plusiinae的研究

金翅夜蛾亚科(Plusiinae)是夜蛾科中一个显著的类群,从眼的睫毛,M_2的存在与前翅通常具有金银斑可以认识。但是不同属、种在外形上区别极少,所以如果不根据生殖器,要正确鉴定所有的属种,几乎是不可能。 这一亚科全世界已记载的约230余种,其分布于古北区的有107种。中国已记载的共70种。陕西省已有记载的只有6种,可能分布到的约21种。1963年朱弘复、陈一心二同志在《中国经济昆虫志(第三册)鳞翅目夜蛾科(一)》一书中记述了11种,提到其中5     

Occurrence and distribution of organochlorine pesticide residue levels in water,sediment and aquatic weeds in the Nyando River catchment,Lake Victoria,Kenya

Samples of water, sediments and aquatic weeds were collected from 26 sites in the Nyando River catchment of the Lake Victoria basin in 2005–2006. The objective was to investigate levels of organochlorine pesticides that have either been banned or are restricted for use in Kenya. The pesticides investigated were lindane, aldrin, endosulfan, endrin, dieldrin, DDT, heptachlor and methoxychlor. These pesticides had previously found wide applications in public health and agriculture in Kenya for control of disease vectors and crop pests respectively. Results showed that mean concentrations were highest for methoxychlor (8.817 ± 0.020?µg l^?1) in water, sediments (92.893 ± 3.039 µg kg^?1), and weeds (39.641 ± 3.045?µg kg^?1), the weeds also tended to accumulate aldrin (15.519 ± 3.756?µg kg^?1). The results show that the pesticides are still in use and are detected in the catchment. Stringent management and public awareness measures are required to enforce the ban on the organochlorine pesticides in order to safeguard the environment and ecosystems of Lake Victoria.     

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma

Multiple Myeloma (MM) is a haematologic malignancy characterized by the accumulation of clonal plasma cells in the bone marrow. Over the last 10–15 y the introduction of the proteasome-inhibitor bortezomib has improved MM prognosis, however relapse due to bortezomib-resistance is inevitable and the disease, at present, remains incurable. To model bortezomib-resistant MM we generated bortezomib-resistant MM cell lines (n = 4 ) and utilised primary malignant plasma cells from patients relapsing after bortezomib treatment (n = 6 ). We identified enhanced Bruton''s tyrosine kinase (BTK) activity in bortezomib-resistant MM cells and found that inhibition of BTK, either pharmacologically with ibrutinib (0.5 μM) or via lenti-viral miRNA-targeted BTK interference, re-sensitized previously bortezomib-resistant MM cells to further bortezomib therapy at a physiologically relevant concentration (5 nM). Further analysis of pro-survival signaling revealed a role for the NF-κB p65 subunit in MM bortezomib-resistance, thus a combination of BTK and NF-κB p65 inhibition, either pharmacologically or via further lenti-viral miRNA NF-κB p65 interference, also restored sensitivity to bortezomib, significantly reducing cell viability (37.5 ± 6 .9 %, ANOVA P ≤ 0 .001). Accordingly, we propose the clinical evaluation of a bortezomib/ibrutinib combination therapy, including in patients resistant to single-agent bortezomib.