排序方式: 共有54条查询结果,搜索用时 15 毫秒
1.
Kumari Anjali Ameri Shijin Ravikrishna Palavancha Dhayalan Arul Kamala-Kannan S. Selvankumar T. Govarthanan M. 《International journal of peptide research and therapeutics》2020,26(2):1051-1059
International Journal of Peptide Research and Therapeutics - Marine snails are abundant sources of biologically important conopeptides with their potential applications in drug development. The... 相似文献
2.
Kumari Anjali Ameri Shijin Marraiki Najat Elgorban Abdallah M. Aroulmoji Vincent Ponnuchamy Kumar Govarthanan Muthusamy Selvankumar Thangaswamy 《International journal of peptide research and therapeutics》2021,27(1):385-395
International Journal of Peptide Research and Therapeutics - The conopeptides are the conotoxin of Conus loroisii have wide applications in drug development. This work emphasizes the isolation and... 相似文献
3.
Kurosh Ameri Anthony M. Rajah Vien Nguyen Timothy A. Sanders Arman Jahangiri Michael DeLay Matthew Donne Hwa J. Choi Kathryn V. Tormos Yerem Yeghiazarians Stefanie S. Jeffrey Paolo F. Rinaudo David H. Rowitch Manish Aghi Emin Maltepe 《PloS one》2013,8(4)
Cellular stress responses are frequently governed by the subcellular localization of critical effector proteins. Apoptosis-inducing Factor (AIF) or Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH), for example, can translocate from mitochondria to the nucleus, where they modulate apoptotic death pathways. Hypoxia-inducible gene domain 1A (HIGD1A) is a mitochondrial protein regulated by Hypoxia-inducible Factor-1α (HIF1α). Here we show that while HIGD1A resides in mitochondria during physiological hypoxia, severe metabolic stress, such as glucose starvation coupled with hypoxia, in addition to DNA damage induced by etoposide, triggers its nuclear accumulation. We show that nuclear localization of HIGD1A overlaps with that of AIF, and is dependent on the presence of BAX and BAK. Furthermore, we show that AIF and HIGD1A physically interact. Additionally, we demonstrate that nuclear HIGD1A is a potential marker of metabolic stress in vivo, frequently observed in diverse pathological states such as myocardial infarction, hypoxic-ischemic encephalopathy (HIE), and different types of cancer. In summary, we demonstrate a novel nuclear localization of HIGD1A that is commonly observed in human disease processes in vivo. 相似文献
4.
Ghadiry Mahdiar Ahmad Harith Hivechi Alieh Tavakoli Fatemeh Manaf Asrulnizam Abd 《Plasmonics (Norwell, Mass.)》2016,11(2):573-577
Plasmonics - Based on the influence of edge effect and channel shape, two new graphene nanoribbon field effect transistors are presented being useful in high-voltage and highly sensitive optical... 相似文献
5.
Real‐Time Investigation of Intercalation and Structure Evolution in Printed Polymer:Fullerene Bulk Heterojunction Thin Films 下载免费PDF全文
Thaer Kassar Nusret S. Güldal Marvin Berlinghof Tayebeh Ameri Andreas Kratzer Bob C. Schroeder Giovanni Li Destri Andreas Hirsch Martin Heeney Iain McCulloch Christoph J. Brabec Tobias Unruh 《Liver Transplantation》2016,6(5)
The complex intermixing morphology is critical for the performance of the nanostructured polymer:fullerene bulk heterojunction (BHJ) solar cells. Here, time resolved in situ grazing incidence X‐ray diffraction and grazing incidence small angle X‐ray scattering are used to track the structure formation of BHJ thin films formed from the donor polymer poly(2,5‐bis(3‐hexadecylthiophen‐2‐yl)thieno[3,2‐b]thiophene) with different fullerene derivative acceptors. The formation of stable bimolecular crystals through the intercalation of fullerene molecules between the side chains of polymer crystallites is investigated. Such systems exhibit more efficient exciton dissociation but lower photo‐conductance and faster decay of charges. On the basis of the experimental observations, intercalation obviously takes place before or with the formation of the crystalline polymer domains. It results in more stable structures whose volume remains constant upon further drying. Three distinct periods of drying are observed and the formation of unidimensional fullerene channels along the π‐stacking direction of polymer crystallites is confirmed. 相似文献
6.
Overcoming Electrode‐Induced Losses in Organic Solar Cells by Tailoring a Quasi‐Ohmic Contact to Fullerenes via Solution‐Processed Alkali Hydroxide Layers 下载免费PDF全文
Hong Zhang R. Clayton Shallcross Ning Li Tobias Stubhan Yi Hou Wei Chen Tayebeh Ameri Mathieu Turbiez Neal R. Armstrong Christoph J. Brabec 《Liver Transplantation》2016,6(9)
It is shown that the performance of inverted organic solar cells can be significantly improved by facilitating the formation of a quasi‐ohmic contact via solution‐processed alkali hydroxide (AOH) interlayers on top of n‐type metal oxide (aluminum zinc oxide, AZO, and zinc oxide, ZnO) layers. AOHs significantly reduce the work function of metal oxides, and are further proven to effectively passivate defect states in these metal oxides. The interfacial energetics of these electron collecting contacts with a prototypical electron acceptor (C60) are investigated to reveal the presence of a large interface dipole and a new interface state between the Fermi energy and the C60 highest occupied molecular orbital for AOH‐modified AZO contacts. These novel interfacial gap states are a result of ground‐state electron transfer from the metal hydroxide‐functionalized AZO contact to the adsorbed molecules, which are hypothesized to be electronically hybridized with the contact. These interface states tail all the way to the Fermi energy, providing for a highly n‐doped (metal‐like) interfacial molecular layer. Furthermore, the strong “light‐soaking” effect is no longer observed in devices with a AOH interface. 相似文献
7.
Polymeroid trilobite fauna from two stratigraphic sections (Godbondar and Kuhbanan) of the Kuhbanan Formation in northern Kerman (central Iran) were studied and subjected to biostratigraphic analysis. Eleven genera and species are recognised from the latest Early Cambrian and Middle Cambrian Peri-Gondwanian successions of the study sections. The recognised fauna includes Afghanocare lategenatum, Blountia blountia, Iranoleesia sp., Iranoleesia pisiformis, Kermanella kuhbananensis, Kermanella lata lata, Kermanella lata minuta, Kermanella sp., Redlichia chinensis, Redlichia noetlingi and Redlichia sp. Based on trilobite distribution, three trilobite biozones were recognised in the study sections, namely Redlichia noetlingi biozone, Kermanella kuhbananensis biozone and Iranoleesia pisiformis biozone. The age of the study sections is late Early Cambrian to late Middle Cambrian based on the recognised trilobite biozones. The recognised late Early Cambrian trilobite assemblages (especially Redlichia and Kermanella) from northern Kerman are similar to those found from some other parts of Gondwana or Peri-Gondwana terrains (north India, Pakistan, northwestern Kashmir, Tajikistan, South Australia, South China and Afghanistan) and show affinities with fauna found in some other parts of Iran (Alborz, northern Iran; Tabas, eastern Iran; southeast Karman). 相似文献
8.
An Alternative Strategy to Adjust the Recombination Mechanism of Organic Photovoltaics by Implementing Ternary Compounds 下载免费PDF全文
9.
Pietro Ameri Santina Bruzzone Elena Mannino Giovanna Sociali Gabriella Andraghetti Annalisa Salis Monica Laura Ponta Lucia Briatore Giovanni F. Adami Antonella Ferraiolo Pier Luigi Venturini Davide Maggi Renzo Cordera Giovanni Murialdo Elena Zocchi 《PloS one》2015,10(2)
The plant hormone abscisic acid (ABA) is present and active in humans, regulating glucose homeostasis. In normal glucose tolerant (NGT) human subjects, plasma ABA (ABAp) increases 5-fold after an oral glucose load. The aim of this study was to assess the effect of an oral glucose load on ABAp in type 2 diabetes (T2D) subjects. We chose two sub-groups of patients who underwent an oral glucose load for diagnostic purposes: i) 9 treatment-naive T2D subjects, and ii) 9 pregnant women with gestational diabetes (GDM), who underwent the glucose load before and 8–12 weeks after childbirth. Each group was compared with matched NGT controls. The increase of ABAp in response to glucose was found to be abrogated in T2D patients compared to NGT controls. A similar result was observed in the women with GDM compared to pregnant NGT controls; 8–12 weeks after childbirth, however, fasting ABAp and ABAp response to glucose were restored to normal in the GDM subjects, along with glucose tolerance. We also retrospectively compared fasting ABAp before and after bilio-pancreatic diversion (BPD) in obese, but not diabetic subjects, and in obese T2D patients, in which BPD resulted in the resolution of diabetes. Compared to pre-BPD values, basal ABAp significantly increased 1 month after BPD in T2D as well as in NGT subjects, in parallel with a reduction of fasting plasma glucose. These results indicate an impaired hyperglycemia-induced ABAp increase in T2D and in GDM and suggest a beneficial effect of elevated ABAp on glycemic control. 相似文献
10.
Overcoming the Thermal Instability of Efficient Polymer Solar Cells by Employing Novel Fullerene‐Based Acceptors 下载免费PDF全文