排序方式: 共有6条查询结果,搜索用时 281 毫秒
1
1.
Esam Aboutaleb Manish Kothari Osama Damrah Roben Canelo 《International Seminars in Surgical Oncology : ISSO》2009,6(1):17
Background
Gastrointestinal stromal tumours are rare (GIST). However, the incidence of GIST among neurofibromatosis type 1 (NF-1) patients is approximately 3.9-25%. GIST can present clinically in different ways such as abdominal pain, gastrointestinal bleeding and obstruction.Case report
We present 51 year female patient admitted with Background of neurofibromatosis type 1 admitted with melena. OGD has been done and showed duodenitis with large volume fresh blood in distal duodenum but no obvious bleeding point. Exploratory laparotomy revealed smooth nodular masses on the serosal surface of jejunum. Small bowel resection and side-to-side anastomosis were performed. Histopathoogical examination revealed small bowel gasrointestinal stromal tumour with low risk malignant potential.Conclusion
The incidence of GIST among neurofibromatosis type 1 (NF-1) patients is not uncommon and we should pay attention to gastrointestinal manifestation in such patients.2.
Nahid Aboutaleb Hamid Kalalianmoghaddam Sanaz Eftekhari Ali Shahbazi Hadi Abbaspour Mehdi Khaksari 《International journal of peptide research and therapeutics》2014,20(2):127-132
Stroke is the third leading cause of death world-wide, affecting 15 million people annually. Diminished blood supply to the brain cells is the main cause of damage following stroke. When focal ischemia occurs, the core of brain tissue influenced by reduced blood supply undergoes necrotic cell death. The adipocytokine Apelin is a peptide that was isolated from a bovine stomach for the first time. This peptide and its receptor are abundantly expressed in the nervous and cardiovascular systems. According to previous studies, Apelin-13 protects cardiomyocytes from ischemic injury and apoptosis. In addition, this peptide has neuroprotective effect on hippocampal and cultured mouse cortical neurons against NMDA receptor-mediated excitotoxicity as well as cortical neurons from ischemic injury. The present study was conducted to determine whether Apelin-13 inhibits apoptosis in the ischemic penumbra in transient focal cerebral ischemia. Focal cerebral ischemia was induced in male Wistar rats by 60 min middle cerebral artery occlusion (MCAO) using a filament method, followed by 23-h reperfusion. Saline as a vehicle and Apelin-13 at doses of 50 and 100 μg were injected intracerebro-ventriculary (ICV) at the beginning of ischemia. Apoptosis and neurological dysfunction were assessed 24-h after MCAO. Our results indicated that administration of Apelin-13 at doses of 50 and 100 μg ICV markedly reduced apoptosis by decreasing positive TUNEL cells (P < 0.001). In addition, Apelin-13 at doses of 100 μg significantly change neurological dysfunction (P < 0.05). Our findings demonstrate that treatment by Apelin-13 exerts its protective effects in ischemic models via blocking programmed cell-death. We suggest that Apelin-13 might be a promising therapeutic target for stroke, although more researches are necessary to take into account the potential therapeutic effects of Apelin-13 in stroke patients. 相似文献
3.
Molecular Biology Reports - Human amniotic membrane mesenchymal stem cells-derived conditioned medium (hAM-MSCs-CM) has positive effects against myocardial ischemia/reperfusion (MI/R) injury.... 相似文献
4.
Sharifi Masoomeh Nazarinia Donya Ramezani Fatemeh Azizi Yaser Naderi Nasim Aboutaleb Nahid 《Molecular biology reports》2021,48(3):2507-2518
Molecular Biology Reports - Nesfatin-1 as a new energy-regulating peptide has been known to display a pivotal role in modulation of cardiovascular functions and protection against... 相似文献
5.
Rakhshan Kamran Azizi Yaser Naderi Nasim Ghardashi Afousi Alireza Aboutaleb Nahid 《International journal of peptide research and therapeutics》2019,25(2):613-621
International Journal of Peptide Research and Therapeutics - Emerging evidence has shown that ELA peptide plays a pivotal role in cardiac development and modulation of vascular and cardiac... 相似文献
6.
1