排序方式: 共有2条查询结果,搜索用时 15 毫秒
1
1.
Nurfida Ablajan Wen-Juan Xue Jiang-Yu Zhao Abdubakiev Sardorbek Nurmirza Boymirzayevich Begmatov Shamansur Sagdullaev Bo Zhao Haji Akber Aisa 《化学与生物多样性》2023,20(3):e202200936
Shawurenine C ( 1a ) and D ( 1b ), a new pair of regioisomeric C19-diterpenoid alkaloids, and five known C19-diterpenoid alkaloids ( 2 – 6 ) were isolated from the aerial part of Delphinium shawurense W. T. Wang. The chemical structures of new compounds were established based on spectroscopic analyses: HR-ESI-MS, and 1D, 2D NMR spectroscopic data. The anti-inflammatory and cytotoxic activities of these diterpenoid alkaloids were also evaluated. 相似文献
2.
Guang-Hui Gou Liu Liu Sardorbek Abdubakiev Xue-Lei Xin Haji Akber Aisa Jun Li 《化学与生物多样性》2023,20(1):e202200904
Piper longum is a well-known spice and traditional medicine. It was revealed to possess anti-diabetic activity, but few information about its active component and underlying mechanism could be available. In this study, retrofractamides A ( 1 ) and C ( 2 ) isolated from P. longum showed potent inhibitory activity against PTP1B. Therefore, the potential mechanism was predicted by network pharmacology and molecular docking. PI3K/AKT was obtained as the most remarkable pathway against type 2 diabetes mellitus (T2DM), and AKT1 and GSK3β were yielded as the top two core targets of retrofractamides A ( 1 ) and C ( 2 ). Molecular docking of compounds with AKT1 and GSK3β showed strong binding affinity between them. Additionally, cellular experiments with a L6 cell model was conducted to further verify the above predictions. Results indicated that retrofractamides A ( 1 ) and C ( 2 ) exerted anti-diabetic effect via activating PI3K/AKT pathway, and they promoted glucose consumption, glucose uptake, glycogen synthesis and glycolysis. 相似文献
1