5个精神分裂症高发家系与COMT关联的分析

本研究旨在探测儿茶酚氧位甲基转移酶基因（COMT）多态性与精神分裂症（SP）的关系,搜寻中国汉族人精神分裂症易患性基因。 应用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）方法对5个精神分裂症高发家系进行初步研究。 用改进的传递/不平衡（TDT）进行统计分析,结果表明,在5个精神分裂症高发家系中,COMT基因与精神分裂症相关联（P=0.0455）。 研究结果提示,在我们研究的家系中,22号染色体长臂（22q11.2）可能存在精神分裂症易患性基因。 Abstract:This study is to explore the relationship between polymorphism of Catechol O-methyltransferase gene and schizophrenia.Search for a gene predisposing to schizophrenia in the Han nationality in China.Five pedigrees with high incidence of schizophrenia were studied by polymerize chain reaction(PCR) and restriction fragment length polymorphism(RFLP) technique.Statistics analysis of the transmission/disequilibrium test (TDT) showed that the COMT gene is associatted with schizophrenia in the five pedigree with high incidence schizophrenia(P=0.0455).The results suggest that there might have a schizophrenia liability gene on 22 chromosome (22q11.2) in our studied pedigrees.